Yunlong Pan

Exosomal Non-Coding RNAs Orchestrate Immune-Metabolic Networks in Triple-Negative Breast Cancer

Huixin Chen, Rong Luo, Jiakang Ma, Weiheng Cui et autres

Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression, limiting the applicability of endocrine and HER2-targeted therapies. Clinically, TNBC exhibits marked molecular heterogeneity, aggressive behavior, early …

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Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang et autres

Cancer therapy-related cognitive impairment (CTRCI) is a debilitating neurotoxic condition adversely impacting cancer patients during and post-cancer treatments. The cancer treatments linked to CTRCI include chemotherapy, hormone therapy, targeted therapy, and immunotherapy. Despite CTRCI severely affecting the psychological and social, cognitive functions, …

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hUMSC-derived exosomes alleviate hypoxic cerebrovascular injury via AMPK/NLRP3-mediated pyroptosis suppression and mitochondrial protection

Yunlong Pan, Haolin Wu, Qingyun Guo, Xingyue Fang et autres

Ranked as the most prevalent cause of death worldwide, ischemic stroke urgently requires innovative therapeutic strategies. The present study demonstrates the therapeutic potential of human umbilical cord-derived mesenchymal stem cell-derived exosomes (hUMSC-Exos) in ameliorating hypoxia-induced cerebrovascular endothelial dysfunction through modulation of the …

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Targeting SLC7A11 with sorafenib sensitizes stereotactic body radiotherapy in colorectal cancer liver metastasis

Jiashuai He, Yiran Zhang, Simin Luo, Zhan Zhao et autres

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Modulation of the electrocatalyzed water-splitting properties of electropolymerized-A2B type co(III) meso-dithien-2-ylcorroles with push-pull properties

Yunlong Pan, Xiaohong Zhang, Xifeng Zhang, Weihua Zhu et autres

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Targeting PLK1-CBX8-GPX4 axis overcomes BRAF/EGFR inhibitor resistance in BRAFV600E colorectal cancer via ferroptosis

Zhan Zhao, Jiashuai He, Shenghui Qiu, Lu Wang et autres

Metastatic BRAFV600E colorectal cancer (CRC) confers poor prognosis and represents a therapeutic bottleneck. To identify resistance mechanisms of the mitogen-activated protein kinase (MAPK) pathway in BRAFV600E CRC, we perform genome-wide CRISPR-Cas9 screening and discover that targeting glutathione peroxidase 4 (GPX4) overcomes resistance …

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Electropolymerized Metallocorroles (M = Co, Cu, Mn) for Enhanced Electrocatalyzed Oxygen Reductions

Yu Chen, Minyu Jiang, Shibin Zhu, Yunlong Pan et autres

New findings in prognostic factor assessment for adenocarcinoma of transverse colon: a comparison study between competing-risk and COX regression analysis

Hongbo Su, Shuping Xie, Shanshan Wang, Liying Huang et autres

Purpose: Competing-risk analysis was used to accurately assess prognostic factors for cancer-specific death in patients with adenocarcinoma of transverse colon (ATC), and the results were compared with those from a conventional Cox regression analysis. Materials and Methods: Patients diagnosed with ATC between …

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LncRNA SND1-IT1 facilitates TGF-β1-induced epithelial-to-mesenchymal transition via miR-124/COL4A1 axis in gastric cancer

Yangzhi Hu, Zhili Hu, Tianyou Liao, Yuan Li et autres

The transformation of tumor cells from an epithelial to a mesenchymal-like phenotype, designated as epithelial-to-mesenchymal transition (EMT), represents a key hallmark of human cancer metastasis, including gastric cancer (GC). However, a large set of non-coding RNAs have been studied for their functions …

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Targeting PELP1 Attenuates Angiogenesis and Enhances Chemotherapy Efficiency in Colorectal Cancer

Jianlin Zhu, Lu Wang, Fan Liu, Jinghua Pan et autres

Abnormal angiogenesis is one of the important hallmarks of colorectal cancer as well as other solid tumors. Optimally, anti-angiogenesis therapy could restrain malignant angiogenesis to control tumor expansion. PELP1 is as a scaffolding oncogenic protein in a variety of cancer types, but …

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The Application of and Strategy for Gold Nanoparticles in Cancer Immunotherapy

Jiashuai He, Shijin Liu, Yiran Zhang, Xiaodong Chu et autres

Immunotherapy of malignant tumor is a verified and crucial anti-tumor strategy to help patients with cancer for prolonging prognostic survival. It is a novel anticancer tactics that activates the immune system to discern and damage cancer cells, thereby prevent them from proliferating. …

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Identification of key biomarkers and potential signaling pathway associated with poor progression of gastric cancer

Yangzhi Hu, Zhili Hu, Hui Ding, Yuan Li et autres

Background: We aimed to identify the key differentially expressed genes (DEGs) associated with poor prognosis in gastric cancer (GC) and to elucidate the underlying molecular mechanisms in order to provide a therapeutic target for this disease. Methods: The DEGs common in two …

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