Jir̆ı́ Drábek

Species-origin identification of the deer in the Purtier Placenta Live Stem Cell Therapy by DNA typing

Lucie Kotková, Shira Vinitzky, Martin LOSKOT, Ondřej Fischer et autres

Purtier Placenta Live Stem Cell Therapy is a food supplement by Riway Singapore Pte. Ltd., claimed to contain living deer placenta stem cells together with 11 other active ingredients. It is also promoted as maintaining health and youthfulness and as being supported …

cz (code pays fourni par la source)

Copy number variation and clinical response to chemotherapy and bevacizumab in the Czech metastatic colorectal cancer patients

Jana Stránská, Karolína Bartáková, Zuzana Rožánková, Lucie Kotková et autres

BACKGROUND: Despite bevacizumab being the first biological agent approved for the treatment of metastatic colorectal cancer (mCRC), there is not any established DNA biomarker to improve its efficacy and personalize the treatment. MATERIALS AND METHODS: Thirty patients with mCRC on bevacizumab therapy …

Relation between residual tumor volume after surgery and overall survival in patients with glioblastoma – a single neuro-oncology center study

Matěj Halaj, Ondřej Kalita, Marek Šlachta, Jan Valošek et autres

Aim: The aim of this study is to demonstrate the technical feasibility of volumetric assessment of residual tumor volume and to evaluate the eff ect of a precisely defi ned residual tumor volume on overall survival (OS) in patients with glioblastoma (GBM) …

Collaborative exercise: analysis of age estimation using a QIAGEN protocol and the PyroMark Q48 platform

Marie‐Louise Kampmann, Jan Fleckhaus, Claus Børsting, Helena Jurtikova et autres

Abstract Human age estimation from trace samples may give important leads early in a police investigation by contributing to the description of the perpetrator. Several molecular biomarkers are available for the estimation of chronological age, and currently, DNA methylation patterns are the …

dk, de, cz, us (code pays fourni par la source)

Dysfunction of peripheral somatic and autonomic nervous system in patients with severe forms of Crohn’s disease on biological therapy with TNFα inhibitors–A single center study

Martin Wasserbauer, Šárka Malá, Kateřina Štechová, Štěpán Hlava et autres

OBJECTIVE: Crohn's disease (CD) can be associated with a wide range of extraintestinal manifestations (EIMs), including neurological ones. Published studies differ in their conclusions about the epidemiology and etiopathogenesis of neurological EIMs. The aims of this study were to demonstrate the presence …

cz (code pays fourni par la source)

Age-Related Changes in Sperm DNA Methylation and their Forensic and Clinical Implications

Lucie Kotková, Jir̆ı́ Drábek

As a link between a stable genome and a dynamic environment, epigenetics is a promising tool for mapping age-related changes in human DNA. Methylated cytosine changes at specific loci are generally less studied in sperm DNA than in somatic cell DNA. Age-related …

cz (code pays fourni par la source)

Clonal hematopoiesis of indeterminate potential is a possible and not yet known cause of stroke

Michal Haršány, Barbora Kalousová, Rastislav Slavkovský, Veronika Kunešová et autres

Factors affecting participation in the colorectal cancer screening program: a cross-sectional population study

Alexandra Romanová, Michala Lustigová, Jana Urbanová, Radan Keil et autres

cz, jp (code pays fourni par la source)

Patient with upgrading ganglioglioma

Marek Šlachta, Ondřej Kalita, Dominik Hraboš, Lumír Hrabálek et autres

Gangliogliom je vzácným primárním nádorem mozku. Predilekčně se vyskytuje supratentoriálně, v temporálním laloku (> 70 %). Nejčastějším klinickým projevem jsou farmakorezistentní epileptické záchvaty. Jeho vzácná, anaplastická, forma je definována histologickými známkami anaplazie v gliální složce nádoru. Pacientka s gangliogliomem WHO grade 1 …

cz (code pays fourni par la source)

Clinical and prognostic significance of detecting CEA, EGFR, LunX, c-met and EpCAM mRNA-positive cells in the peripheral blood, tumor-draining blood and bone marrow of non-small cell lung cancer patients

Alona Řehulková, Andrea Prokopova, Monika Vidlařová, Jana Stránská et autres

Background: Surgical treatment of early-stage non-small cell lung cancer (NSCLC) yields highest expectations for recovery. However, the frequency of further disease progression remains high since micro-metastatic disease may be undetected by conventional diagnostic methods. We test the presence and prognostic impact of …

cz, sk (code pays fourni par la source)

Clonal hematopoiesis of indeterminate potential in ischemic stroke – study protocol

Michal Haršány, Veronika Kunešová, Barbora Kalousová, Rastislav Slavkovský et autres

Efficacy and safety of SARS-CoV-2 vaccination in patients with inflammatory bowel disease on immunosuppressive and biological therapy: Prospective observational study

Martin Wasserbauer, Štěpán Hlava, Milan Trojánek, Jan Šťovíček et autres

BACKGROUND AND AIMS: SARS-CoV-2 is a worldwide serious health problem and vaccination seems to have a crucial role in managing the COVID-19 pandemic. The aim of this prospective observational study was to monitor the trend of antibodies against SARS-CoV-2 after vaccination with …

cz (code pays fourni par la source)