A Systematic Review of Depth-Dependent Cytoprotection with Therapeutic Hypothermia for Cerebral Ischemia
Marin R. Parranto, Tiffany F.C. Kung, Lane J. Liddle, Tayyaba Khalid et autres
Preclinical studies show that therapeutic hypothermia (TH) effectively reduces cerebral ischemic injury. In contrast, TH has not been consistently beneficial in clinical trials of stroke and cardiac arrest, perhaps from suboptimal dosing (e.g., delay, depth, and duration), among other factors. This systematic …
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