Abu Sufiyan Chhipa

Pathophysiological mechanisms, potential biomarkers, and therapeutic interventions in diabetic nephropathy

Kuldip Vyas, Abu Sufiyan Chhipa, Ayush Chauhan, Snehal S Patel

Diabetic nephropathy (DN) is a diabetic complication that leads to the progressive deterioration of kidney function. Oxidative stress and inflammation play crucial roles in the pathogenesis of DN. Oral hypoglycemic agents such as sodium-glucose co-transporter 2 inhibitors, glucagon-like peptide 1 agonists, and …

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Apoptosis-inducing potential of tilorone dihydrochloride in triple-negative breast cancer: in silico and in vitro evidences

Abu Sufiyan Chhipa, Valentina Boscaro, Margherita Gallicchio, Alice Ferro et autres

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Design, synthesis and biological evaluation of thiadiazole derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors and anticancer agents

Pinky Gehlot, Sunil Kumar, Abu Sufiyan Chhipa, Anam Sami et autres

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PP030 Anticancer effects of doxorubicin in combination with tilorone in breast cancer

Snehal Patel, Abu Sufiyan Chhipa, Margherita Gallicchio, Valentina Boscaro

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Corrigendum to “Synergistic anticancer effects of doxorubicin in combination with tilorone in breast cancer” [European J. Pharmacol. 1008 (2025) 178249]

Abu Sufiyan Chhipa, Margherita Gallicchio, Valentina Boscaro, Snehal G. Patel

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Synergistic anticancer effects of doxorubicin in combination with tilorone in breast cancer

Abu Sufiyan Chhipa, Margherita Gallicchio, Valentina Boscaro, Snehal Sanjay Patel

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The efficacy of helium generated cold atmospheric plasma for skin disinfection

Abu Sufiyan Chhipa, Divyesh Patel, Snehal Sanjay Patel, Priti Jignesh Mehta et autres

The present study was performed to evaluate the disinfecting effects of helium-generated cold atmospheric plasma (He-CAP) against bacteria. The study further explored the biosafety of He-CAP. Antibacterial effects of He-CAP were evaluated on gram-positive Staphylococcus aureus and gram-negative Pseudomonas aeruginosa. Optimization was …

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The curious case of type I interferon signaling in cancer

Abu Sufiyan Chhipa, Valentina Boscaro, Margherita Gallicchio, Snehal Sanjay Patel

Cytokines are the crucial signaling proteins that mediate the crosstalks between the cells of tumor microenvironment (TME). Interferon-1 (IFN-1) are the important cytokines that are widely known for their tumor suppressive roles comprising of cancer cell intrinsic and extrinsic mechanisms. Despite having …

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Discovery and Biological Evaluation of Novel Fluorinated Derivatives of Benzophenone Analogues as Potent Anti‐Cancer Agent: Synthesis, In Vitro Assay and Molecular Dynamics

Vikrant H. Pandya, Abu Sufiyan Chhipa, Ravi N. Kalariya, Krunal Modi et autres

Abstract A range of new fluorinated derivatives of benzophenone analogs were developed and assessed on the human MDA‐MB‐231 triple‐negative breast cancer cell line and human cervical carcinoma cell line KB‐3‐1 for cytotoxic and anti‐proliferative effects. Synthesized derivatives were characterized by 1 H …

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Therapeutic effects of tilorone on mammary carcinogenesis through downregulation of pro‐inflammatory cytokines and oxidative stress

Abu Sufiyan Chhipa, Ayush Sharma, Srashti Verma, Snehal Sanjay Patel

Abstract Tilorone dihydrochloride (tilorone) is an orally active interferon inducer with anticancer effects. The present study aimed to evaluate the anticancer effects of tilorone in breast cancer. MTT assay was done to measure the proliferation of MCF‐7 and MDA‐MB‐231 breast cancer cells …

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Olsalazine pretreatment augments chemosensitivity of gemcitabine in hepatocellular carcinoma

Ayush Sharma, Abu Sufiyan Chhipa, Srashti Verma, Palak K. Parikh et autres

Recently, olsalazine a DNA hypomethylating agent was found to inhibit the growth of breast cancer cells. The present study was carried out to evaluate the effects of olsalazine pretreatment in the potentiation of chemosensitivity of gemcitabine for the treatment of hepatocellular carcinoma …

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CRISPR-Cas based diagnostic tools: Bringing diagnosis out of labs

Abu Sufiyan Chhipa, Ekta Radadiya, Snehal Sanjay Patel

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