TBK1 is a synthetic lethal target in cancer with VHL loss
Xinnan Chen, L.E. Herring, L.I. James, Xingchen Tan et autres
TANK binding kinase 1 (TBK1) is an important kinase involved in the innate immune response. Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. Tumors from patients with kidney cancer with VHL loss display …
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