Ryuta Sobu

IL-8 blockade enhances anti-PD-1 therapeutic activity in renal cell carcinoma in a next-generation patient-derived xenograft model

Ryuta Sobu, Yuka Kobayashi, Soki Kashima, Takamitsu Inoue et autres

Immune checkpoint inhibitors (ICIs) are widely used for advanced renal cell carcinoma (aRCC); however, predictive biomarkers of response remain insufficiently defined, and treatment resistance is common. We comprehensively analyzed clinical samples from 51 patients with aRCC treated with anti-PD-1 therapy to identify …

jp, us (code pays fourni par la source)

MP28-07 MONOCYTIC MYELOID-DERIVED SUPPRESSOR CELLS EXHIBIT PRIMARY RESISTANCE TO NIVOLUMAB PLUS IPILIMUMAB IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA

Kazuyuki Numakura, Ryuta Sobu, Soki Kashima, Ojiro Tokairin et autres

MP33-01 GERIATRIC ASSESSMENT IN OLDER PATIENTS WITH UROLOGICAL CANCERS UNDERGOING SURGERY OR SYSTEMIC THERAPY

Ryuta Sobu, Shintaro Narita, Yuya Sekine, Hiromi Sato et autres

P295 – Monocytic myeloid-derived suppressor cells exhibit primary resistance to nivolumab plus ipilimumab in patients with metastatic renal cell carcinoma

K. Numakura, Ryuta Sobu, S. Kashima, Y. Sekine et autres

The lymphocyte-to-monocyte ratio as a significant inflammatory marker associated with survival of patients with metastatic renal cell carcinoma treated using nivolumab plus ipilimumab therapy

Kazuyuki Numakura, Yuya Sekine, Takahiro Osawa, Sei Naito et autres

jp (code pays fourni par la source)

Real clinical outcomes of nivolumab plus ipilimumab for renal cell carcinoma in patients over 75 years old

K. Numakura, M. Kobayashi, Shingo Hatakeyama, Yuta Muto et autres

Germline HLA-DQB1*03:01 is an independent prognostic factor for clinical outcomes in patients with urothelial cancer treated with pembrolizumab

Naofumi Narita, Shunji Takahashi, Nobuhiro Fujiyama, Shingo Hatakeyama et autres

Comparison of perioperative outcomes and complications between intracorporeal, extracorporeal, and hybrid ileal conduit urinary diversion during robot-assisted radical cystectomy: a comparative propensity score-matched analysis from nationwide multi-institutional study in Japan

Shuichi Morizane, Keita Nakane, Toshiaki Tanaka, Kenji Zennami et autres

jp (code pays fourni par la source)

The Current Trend of Radiation Therapy for Patients with Localized Prostate Cancer

Kazuyuki Numakura, Mizuki Kobayashi, Yumina Muto, Hiromi Sato et autres

A recent approach to radiotherapy for prostate cancer is the administration of high doses of radiation to the prostate while minimizing the risk of side effects. Thus, image-guided radiotherapy utilizes advanced imaging techniques and is a feasible strategy for increasing the radiation …

jp (code pays fourni par la source)

BRCA2 Frameshift Mutation in de novo Small-Cell Neuroendocrine Carcinoma of the Prostate: A Case Report

Keisuke Okubo, Shintaro Narita, Atsushi Koizumi, Yoshiko Takahashi et autres

A 66-year-old male was diagnosed with cT4N0M1b small-cell neuroendocrine carcinoma of the prostate. Four months after the administration of combined androgen blockade, multiple novel metastatic regions in the lung and liver and progression of bone metastasis were observed. The patient was referred …

jp (code pays fourni par la source)

Real clinical outcomes of nivolumab plus ipilimumab for renal cell carcinoma in patients over 75 years old

Mizuki Kobayashi, Kazuyuki Numakura, Shingo Hatakeyama, Toshiya Ishida et autres

jp (code pays fourni par la source)

Comparison of perioperative outcomes and complications between intracorporeal, extracorporeal, and hybrid ileal conduit urinary diversion during robot-assisted radical cystectomy: A comparative propensity score-matched analysis from nationwide multi-institutional study in Japan

Shuichi Morizane, Keita Nakane, Toshiaki Tanaka, Kenji Zennami et autres

Abstract Background To investigate the impact of different urinary diversion (UD) techniques on the peri- and postoperative complications of robot-assisted radical cystectomy (RARC) with ileal conduit. Methods We retrospectively analyzed 373 patients undergoing RARC with ileal conduit at 11 institutions in Japan …

jp, us (code pays fourni par la source)