In Ho Park

Abstract 3960: Spatially resolved transcriptomic signatures of gallbladder carcinogenesis from precursor to undifferentiated stages

Yeseul Kim, Yoseob Lee, Harim Oh, Y. M. Sung et autres

Abstract Background: Biliary intraepithelial neoplasia (BilIN) is recognized as a precursor lesion of gallbladder carcinoma. However, the transcriptomic alterations underlying the sequential process of carcinogenesis remain poorly understood. Moreover, the differentiation status of gallbladder carcinoma varies among patients, with some tumors exhibiting …

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DNA-PKcs orchestrates CTLA-4 depletion-induced senescence in cancer cells

Je-Jung Lee, Woo Joong Rhee, So Young Kim, Jisun Lee et autres

Immune checkpoints such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death 1 (PD-1), and programmed cell death ligand 1 (PD-L1) have been targeted in cancer therapy, however, the efficacy of these interventions remains limited. Beyond its immune function on T cell …

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SPOT!: Map-Guided LLM Agent for Unsupervised Multi-CCTV Dynamic Object Tracking

Yujin Roh, In Ho Park, Chigon Hwang

CCTV-based vehicle tracking systems face structural limitations in continuously connecting the trajectories of the same vehicle across multiple camera environments. In particular, blind spots occur due to the intervals between CCTVs and limited Fields of View (FOV), which leads to object ID …

SPOT!: Map-Guided LLM Agent for Unsupervised Multi-CCTV Dynamic Object Tracking

Yujin Noh, In Ho Park, Chigon Hwang

CCTV-based vehicle tracking systems face structural limitations in continuously connecting the trajectories of the same vehicle across multiple camera environments. In particular, blind spots occur due to the intervals between CCTVs and limited Fields of View (FOV), which leads to object ID …

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Spatial analysis of tumor immune microenvironment of TNBC with different neoadjuvant chemotherapy outcomes using multiplex Immunofluorescence

In Ho Park, Su‐Jin Shin, Heounjeong Go, Jiwon Ko et autres

BACKGROUND: Triple-negative breast cancer (TNBC) is characterized by aggressive biological behavior and poor prognosis. However, TNBC exhibits higher immunogenicity than other breast cancer subtypes, making it more responsive to immunotherapy. Neoadjuvant chemotherapy (NAC) is the standard treatment for early high-risk TNBC; however, …

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Adult K18-hACE2 mice are suitable for studying intranasal SARS-CoV-2 infection but not direct-contact transmission

Jiseon Kim, Sung-Hee Kim, Donghun Jeon, Haengdueng Jeong et autres

The rapid global spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) since 2019 emphasizes the need to understand its transmission routes, which mainly comprise airborne and contact transmission. Contact transmission, where the virus spreads through direct or indirect contact, is key to …

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A Digital LDO with Single-VCO-Based Time Quantizer for Fast Load-Transient Response

Sungjun Moon, Jong Hun Chae, In Ho Park

This paper presents a digital low-dropout regulator employing a single-VCO-based AC-coupled time quantizer and a three-level switched-capacitor (SC) gate driver for fast transient response and reduced output ripple. The proposed time quantizer dynamically increases the clock frequency in response to VOUT change, …

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A Hybrid Dual-Path Buck Converter Relaxing Duty Cycle Control for Li-Ion Battery Applications

Jong Hun Chae, Sungjun Moon, In Ho Park

This paper presents a hybrid buck converter achieving a wide voltage conversion ratio (VCR) range from 0 to 1 with the single-mode operation for Li-ion battery applications. It operates in three phases using seven power switches, a flying capacitor, and a single …

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Apomorphine is a novel necroptosis inhibitor targeting mixed lineage kinase domain-like protein oligomerization

Myeonggil Han, Dong-Hyun Seo, Man Sup Kwak, In Ho Park et autres

Necroptosis, a form of programmed cell death, has emerged as a promising therapeutic target. Although several RIPK1 inhibitors have demonstrated favorable safety profiles in clinical trials, clinical translation of necroptosis-targeted therapies remains limited by modest efficacy, limited specificity, and species-specific activity of …

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A Study on Reform Measures for the Duty of Disclosure, Including the Introduction of Passive Disclosure

In Ho Park

2010년을 전후하여 해외 보험 선진국들이 고지의무 수동화를 도입하는 방향으로 법 개정을 추진하였다. 이러한 변화를 반영하여 우리나라에서도 2010년경부터 고지의무 수동화에 대한 논의가 활발히 이루어졌다. 고지의무 수동화 도입 논의는 현행 고지의무제도가 보험계약자에게 지나치게 불이익하여 보험의 신뢰를 침해하고 있다는 문제점의 인식에서 출발하여, 보험계약자 보호하기 위한 …

Climate Change and the Evolving Role of Insurance

In Ho Park

기후변화는 기온상승에 따른 자연재해의 단순 증가뿐만 아니라 생태계의 변화와 그로 인한 질병의 변화 등 인간의 생활에 광범위한 영향을 미치고 있다. 기후변화는 날씨 변동성을 증가시키고 날씨 예측을 어렵게 함으로써 여러 산업에도 영향을 미치고 있다. 그리고 이상기후로 인한 날씨 예측 실패는 막대한 사회적 비용을 …

Reduction of lymphotoxin beta receptor induces cellular senescence via the MDMX-p53 pathway

So Young Kim, Bin Lee, Je‐Jung Lee, Man Sup Kwak et autres

Abstract The lymphotoxin β receptor (LTβR), a key activator of non-canonical NF-κB signaling, is expressed in various cells, including cancer cells. Although high expression of LTβR has been associated with poor patient prognosis and drug resistance, conflicting evidence suggested that LTβR induces …

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