Saïd Afqir

Primary Cutaneous Epithelioid Hemangioendothelioma of the Scalp With Pulmonary, Hepatic, and Osseous Metastases: A Case Report

Nada Tahri, K. Belharti, Rania Bouabdellaoui, Soufia El Ouardani et autres

An Unusual Destination: Neuroendocrine Carcinoma Arising in the Breast, an Uncommon and Aggressive Entity

Hanan Bailal, Fadoua Jebrouni, Kaouthar Khater, Asmae Bali et autres

Neuroendocrine-differentiated breast carcinoma is an uncommon and challenging subtype of breast cancer, with aggressive clinical behavior. Owing to the limited number of reported cases and the lack of standardized treatment guidelines, its clinical presentation, natural history, and optimal management remain poorly defined, …

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Vulvar Metastasis From Colorectal Adenocarcinoma: A Report of a Rare Case and Review of Diagnostic and Therapeutic Approaches

Kaouthar Khater, Hanan Bailal, Fadoua Jebrouni, Asmae Bali et autres

Vulvar metastasis from colorectal adenocarcinoma is extremely rare, with few cases reported in the literature. We present the case of a 49-year-old woman with a history of locally advanced, moderately to well-differentiated invasive adenocarcinoma of the distal rectum treated with neoadjuvant chemotherapy …

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Artificial Intelligence in the Management of Breast Cancer: A Comprehensive Review

Soufia El Ouardani, Hind Chibani, Farah El Ouardani, Sami Aziz Brahmi et autres

Artificial intelligence (AI) has rapidly emerged as a transformative tool in modern medicine, particularly in oncology, where it has shown significant potential in improving diagnostic accuracy and early detection of cancer. Breast cancer remains one of the most prevalent malignancies worldwide, and …

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When the Cecum Hides a Sarcoma: A Rare Case of Undifferentiated Malignancy

Soufia El Ouardani, Hanan Bailal, Mohamed Mouhoub, Hind Chibani et autres

Primary undifferentiated sarcoma of the cecum is an exceptionally rare and aggressive mesenchymal tumor, often difficult to diagnose due to its nonspecific presentation and overlap with more common colonic malignancies. We report the case of a 66-year-old patient presenting with right iliac …

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MAPK-targeted therapies in non-gastrointestinal stromal tumor soft tissue sarcomas: current landscape and future directions

Ouissam Al Jarroudi, Khalid El Bairi, Sami Aziz Brahmi, Saïd Afqir

Non-Gastrointestinal Stromal Tumors (Non-GIST) Soft Tissue Sarcomas (STS) are highly aggressive and challenging diseases with poor prognosis and limited therapeutic options. Molecular profiling is urgently required to gain a deeper understanding of STS pathogenesis and to identify a comprehensive landscape of genomic …

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C-KIT Mutant Anorectal Melanoma: Diagnostic Pitfalls and Treatment Perspectives

Hanan Bailal, Soufia El Ouardani, Fadoua Jebrouni, Hind Chibani et autres

Mucosal melanomas (MM) are an uncommon and aggressive subtype of melanoma that differ from cutaneous forms in both genetic profile and clinical behavior. Anorectal melanoma (ARM), in particular, is characterized by its rapid progression and distinct molecular alterations, notably mutations in the …

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A Rare Case of Low-Grade Endometrial Stromal Sarcoma: Diagnostic Insights and Therapeutic Considerations

Soufia El Ouardani, Hind Chibani, H. Hadj Kacem, Sami Aziz Brahmi et autres

Low-grade endometrial stromal sarcoma (LGESS) is a rare malignant tumor of the uterus, often misdiagnosed due to its indolent progression and nonspecific clinical presentation. We report the case of a 49-year-old perimenopausal woman who presented with abnormal uterine bleeding and pelvic pain. …

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Unusual psoas metastasis of a primary colic adenocarcinoma: A case report

Mohammed Bendimya, Soufia El Ouardani, Ouissam Al Jarroudi, Sami Aziz Brahmi et autres

Colorectal cancer ranks as the third most prevalent cancer globally; however, skeletal muscle metastases that originate from colonic adenocarcinoma are exceedingly rare. This article describes the treatment of a 63-year-old woman diagnosed with colonic cancer classified as T3N1M0. Three months later, the …

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Muscle Metastasis as an Atypical Presentation of Non-small Cell Lung Cancer: A Case Report and Literature Review

Fatima Rezzoug, Jihane Derfoufi, Ouissam Al Jarroudi, Sami Aziz Brahmi et autres

Skeletal muscle metastases from non-small cell lung cancer (NSCLC) are rare and often clinically silent, representing an uncommon site of disease dissemination and accounting for approximately 2.3% of cases. Diagnosis is frequently delayed due to nonspecific symptoms and imaging findings that can …

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Primary vaginal leiomyosarcoma: A case report emphasizing multidisciplinary care of a rare entity

Fadoua Jebrouni, Hanan Bailal, Mouhsine Omari, Kaouthar Khater et autres

Leiomyosarcoma (LMS) is a rare malignant tumor derived from smooth muscle cells. It usually occurs in the uterine cavity, other localizations, such as vaginal leiomyosarcoma, are atypical. Due to the nonspecific nature of its clinical presentation, vaginal LMS may be misdiagnosed as …

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Chromophobe Renal Cell Carcinoma With Sarcomatoid Differentiation: A Case Report and Review of the Literature

Mouhsine Omari, Mohammed Bendimya, Fadoua Jebrouni, Nassira Karich et autres

Chromophobe renal cell carcinoma is a rare entity with an excellent prognosis compared with clear renal cell carcinoma and is characterized by distinct molecular and genetic specificity. The presence of a sarcomatoid component is an uncommon phenomenon, which indicates a high risk …

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