Angharad Marks

Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes

Lawrence J. Appel, Morgan E. Grams, Mark Woodward, Katie Harris et autres

Importance: Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximately 14% of adults in the US. Objective: To evaluate associations of lower eGFR based on creatinine alone, lower eGFR based on creatinine combined with cystatin C, and more …

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Major cardiovascular events and subsequent risk of kidney failure with replacement therapy: a CKD Prognosis Consortium study

Patrick B. Mark, Juan Jesús Carrero, Kunihiro Matsushita, Yingying Sang et autres

AIMS: Chronic kidney disease (CKD) increases risk of cardiovascular disease (CVD). Less is known about how CVD associates with future risk of kidney failure with replacement therapy (KFRT). METHODS AND RESULTS: The study included 25 903 761 individuals from the CKD Prognosis …

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Cost-effectiveness and value of information analysis of multiple frequency bioimpedance devices for fluid management in people with chronic kidney disease having dialysis

Elisabet Jacobsen, Moira Cruickshank, David Cooper, Angharad Marks et autres

BACKGROUND: Among people with chronic kidney disease (CKD) on dialysis, sub-optimal fluid management has been linked with hospitalisation, cardiovascular complications and death. This study assessed the cost-effectiveness using multiple-frequency bioimpedance guided fluid management versus standard fluid management based on clinical judgment. METHODS: …

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Validation of Risk Prediction Models to Inform Clinical Decisions After Acute Kidney Injury

Simon Sawhney, Zhi Tan, Corri Black, Angharad Marks et autres

RATIONALE & OBJECTIVE: There is limited evidence to guide follow-up after acute kidney injury (AKI). Knowledge gaps include which patients to prioritize, at what time point, and for mitigation of which outcomes. In this study, we sought to compare the net benefit …

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Multimorbidity in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Results From a Longitudinal, Multicenter Data Linkage Study

Shifa Sarica, Peter J. Gallacher, Neeraj Dhaun, J Sznajd et autres

OBJECTIVE: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is considered a chronic, relapsing condition. To date, no studies have investigated multimorbidity in AAV nationally. This study was undertaken to characterize temporal trends in multimorbidity and report excess health care expenditures associated with multimorbidities in …

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P0560POST-DISCHARGE FOLLOW UP AFTER AKI. AN EXTERNAL VALIDATION AND DECISION CURVE ANALYSIS OF TWO RISK MODELS

Simon Sawhney, Zhi Tan, Corri Black, Brenda R. Hemmelgarn et autres

Abstract Background and Aims There is limited evidence to inform which people should receive follow up after AKI and for what reasons. Here we report the external validation (geographical and temporal) and potential clinical utility of two complementary models for predicting different …

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P0783PREVALENCE AND PROGNOSIS OF HYPERKALAEMIA IN PEOPLE HOSPITALISED WITH AND WITHOUT AKI

Andrew Mclean, Corri Black, Angharad Marks, Simon Sawhney

Abstract Background and Aims Hyperkalemia is a clinical emergency associated with kidney diseases and hospital mortality. It may be apparent on initial hospital presentation, or develop during the course of admission, and can occur in the context of AKI. The prevalence of …

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Characterizing infection in anti-neutrophil cytoplasmic antibody–associated vasculitis: results from a longitudinal, matched-cohort data linkage study

Shifa Sarica, Neeraj Dhaun, J Sznajd, John Harvie et autres

OBJECTIVES: Infection exerts a major burden in ANCA-associated vasculitis (AAV), however, its precise extent and nature remains unclear. In this national study we aimed to longitudinally quantify, characterize and contextualize infection risk in AAV. METHODS: We conducted a multicentre matched cohort study …

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Urban–rural and socioeconomic status: Impact on multimorbidity prevalence in hospitalized patients

Lynn Robertson, Dolapo Ayansina, Marjorie C. Johnston, Angharad Marks et autres

Objective: The aim of this study was to describe multimorbidity prevalence in hospitalized adults, by urban–rural area of residence and socioeconomic status (SES). Methods: Linked hospital episode data were used. Adults (≥18 years) admitted to hospital as an inpatient during 2014 in …

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127. MULTI-METHOD CHARACTERIZATION OF INFECTION IN ANCA-ASSOCIATED VASCULITIS: RESULTS: FROM A LONGITUDINAL, MATCHED-COHORT DATA LINKAGE STUDY

Shifa Sarcia, Neeraj Dhaun, J Sznajd, John Harvie et autres

Background: Infection exerts a major burden in AAV; however, the precise extent and nature of this risk remains unclear. There are multiple epidemiological methods to measure infection. All are associated with strengths and weaknesses. Previous AAV studies of infection have been limited …

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Measuring multimorbidity in hospitalised patients using linked hospital episode data: comparison of two measures

Lynn Robertson, Dolapo Ayansina, Marjorie C. Johnston, Angharad Marks et autres

INTRODUCTION: Multimorbidity is a complex and growing health challenge. There is no accepted "gold standard" multimorbidity measure for hospital resource planning, and few studies have compared measures in hospitalised patients. AIM: To evaluate operationalisation of two multimorbidity measures in routine hospital episode …

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Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies

Josef Coresh, Hiddo J.L. Heerspink, Yingying Sang, Kunihiro Matsushita et autres

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