Hong Zhang

Sophocarpine Alleviates Airway Epithelial Cell Inflammation in Asthma via Modulating the Cytokine- Cytokine Receptor and JAK2/STAT3 Signaling Pathways

Wenbing Zhi, Hong Zhang, Ziyao Qiao, Shengnan Jiang et autres

Purpose: Asthma is a complex, heterogeneous, and inflammatory disease with an increasing incidence worldwide. This study aimed to investigate the therapeutic mechanisms of sophocarpine in asthma systematically. Methods: A house dust mite (HDM)-induced mouse and cell model was built. The effects and …

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Siji Kangbingdu Mixture Ameliorates LPS-Induced Acute Lung Injury by Downregulating the TNF/IL-17 Signaling Pathways: A Comprehensive Study Using Transcriptomics, Network Pharmacology and Experimental Verification

Yuan Wang, Huiying Zhou, Bo Wang, Liu Yuxi et autres

Background: Acute lung injury (ALI), as a respiratory condition triggered by various internal and external factors, is characterized clinically by high rates of incidence and mortality. In the current context where respiratory system diseases are on the rise, the incidence of ALI …

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Oxysophocarpine Inhibits Apoptosis of Lung Epithelial Cells to Alleviate Acute Lung Injury via KIT/PI3K Signaling Pathway

Kaihua Long, Kefeng Ding, Xiaoyan Zhang, Xiaoli Gao et autres

Purpose: , possesses anti-inflammatory and antioxidant properties. However, its effects on ALI are still unclear. This study aims to investigate the role and potential mechanisms of OSC for the treatment of ALI. Methods: The levels of TNF-α, IL-6, and IL-1β in bronchoalveolar …

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Qingwen Hufei Granules Attenuate Lipopolysaccharide-Induced Acute Lung Injury by Suppressing NLRP3 Inflammasome-Dependent Pyroptosis

Kaihua Long, Yun Peng Yang, Yuan Wang, Wei Wang et autres

Background: Currently, clinical treatments for ALI include vasodilators, glucocorticoids, and mechanical ventilation; however, these therapies are associated with various adverse reactions. Therefore, there is a need to develop safer and more effective treatment options. Traditional Chinese Medicine (TCM), particularly Qingwen Hufei Granules …

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Design of 77 GHz EM Band Gap Structure Considering Manufacturing Constraints

Fei Qiu, Hong Zhang, Zhen Zhang, Xin Dai

This work proposes a 77 GHz electromagnetic band gap (EBG) structure design method that balances manufacturing constraints to address mutual coupling suppression in millimeter-wave radar systems. In this proposed method, an initial mushroom-type EBG unit is designed based on bandgap characteristics. Then, …

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Machine learning-driven discovery of STAT3 as a pivotal target for Wen-Wei-San-Ji formula in chronic atrophic gastritis therapy

Tingting Huang, Lu Wang, Mengru Dou, Jia Guo et autres

Background Wen-Wei-San-Ji Formula (WWSJ) is a Traditional Chinese medicine (TCM) formula used in treatment of chronic atrophic gastritis (CAG), demonstrating significant clinical efficacy. However, its specific mechanism of action remains unclear. This study investigates the molecular mechanisms and active components of WWSJ …

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Saposhnikovia Divaricata-Fructus Mume Herb Pair Alleviates Airway Inflammation in Asthma by Inhibiting Il-17 Secretion From Γδt17 Cells Via The Notch1 Signaling Pathway

Can Zou, Jialing Xie, Quan Luo, Yuru Li et autres

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Integrative Gut Microbiota and Metabolomic Analyses Reveal the PANoptosis- and Ferroptosis-Related Mechanisms of Chrysoeriol in Inhibiting Melanoma

Yuxi Liu, Lu Wang, Tingting Huang, Ye Li et autres

Chrysoeriol, a natural flavonoid, has shown potential in inhibiting melanoma. However, the detailed molecular mechanisms of its action still need to be clarified. In this study, chrysoeriol showed significant suppressive effects on melanoma progression in a mouse model. The integrative gut microbiota …

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Traditional Chinese Medicine in the treatment of chronic atrophic gastritis, precancerous lesions and gastric cancer

Yuxi Liu, Tingting Huang, Lu Wang, Yuan Wang et autres

ETHNOPHARMACOLOGICAL RELEVANCE: Chronic atrophic gastritis (CAG), precancerous lesions of gastric cancer (PLGC), and gastric cancer (GC), seriously threaten human health. Traditional Chinese medicine (TCM) has been employed in the treatment of chronic diseases for a long time and has shown remarkable efficacy. …

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COVID-19 and Chinese nurses' mental health

Hong Zhang

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Research progress of diosgenin extraction from Dioscorea zingiberensis C. H. Wright: Inspiration of novel method with environmental protection and efficient characteristics

Xinxin Zhang, Yu Zhang, Yuting Guo, Zhaowei Xue et autres

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Recent advances of traditional Chinese medicine for the prevention and treatment of atherosclerosis

Wenbing Zhi, Yang Liu, Xiumei Wang, Hong Zhang

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