Xianchun Wen

Co-encapsulated with shikonin/doxorubicin pH-sensitive liposomes: Preparation, characterization and its synergistic effect in drug-resistant breast cancer cells

Huilin Deng, Hao Zhang, Ying Zhao, Tingting Chen et autres

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Preparation of RGD-modified liposomes encapsulated with shikonin and its targeted anti-melanoma effects

Hao Zhang, Ying Zhao, Tingting Chen, Xinliang Mao et autres

Melanoma is the most aggressive skin tumor, and conventional treatment is ineffective. Studies have shown that shikonin, derived from the traditional Chinese medicine Lithospermum erythrorhizon , has various anticancer activities. In this work, RGD- modified liposomes encapsulated with shikonin (RGD-Lip-SHK) were prepared …

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Preparation, in vitro anti-tumour activity and in vivo pharmacokinetics of RGD-decorated liposomes loaded with shikonin

Jiping Li, Hao Zhang, Xinliang Mao, Huilin Deng et autres

Shikonin (SHK) has been evidenced to possess effects against various cancer cells. However, poor aqueous solubility and high toxicity restrict its application. In the study, RGD-decorated liposomes loaded with SHK (RGD-Lipo-SHK) were prepared via thin-film hydration method. Characterization and cellular uptake of …

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A pH-Responsive Nanoplatform Based on Magnetic Mesoporous Silica Nanoparticles for Enhanced Treatment of Pancreatic Cancer

Guiqiang Qi, Shengchao Wang, Qiangqiang Yin, Zhichen Zhang et autres

This study presents the pH-responsive nanoplatform DOX@M-MSN-5-FAM@PDA (DM-F@P) to improve the treatment of pancreatic cancer. DM-F@P is a combination of magnetic mesoporous silica nanoparticles (M-MSN) and a pH-responsive polydopamine (PDA) outer layer to ensure the controlled delivery of loaded drugs. The combination …

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Resource electronic database for measuring regional cultural influence based on machine learning big data

Tingting Chen, Yujing Dong, Xianchun Wen

Abstract With the advent of the information age, the use of various mobile terminal devices has accelerated the integration of local cultures, which has also brought many unstable factors to society while promoting cultural diversification. This article aims to build a resource …

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mmu_circ_0000790 Is Involved in Pulmonary Vascular Remodeling in Mice with HPH via MicroRNA-374c-Mediated FOXC1

Lei Yang, Huan Liang, Xianguo Meng, Li Shen et autres

Recently, the identification of several circular RNAs (circRNAs) as vital regulators of microRNAs (miRNAs) underlines the increasing complexity of non-coding RNA (ncRNA)-mediated regulatory networks. This study aimed to explore the effects of mmu_circ_0000790 on the biological behaviors of pulmonary artery smooth muscle …

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Cultivation Path of Medical Students’ Tacit Professional Quality in the Age of “Wise Information Technology of 120” Based on the Framework of Collaboration between Medicine and Education

Tingting Chen, Wangting Li, Xianchun Wen, Han Lin

This work studied the new requirements of the tacit professional quality on medical students in the era of "Wise Information Technology of 120", and aimed to explore ways and means to cultivate qualified medical students.The research group used literature review, research visits …

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Anticancer Efficacy of Targeted Shikonin Liposomes Modified with RGD in Breast Cancer Cells

Xianchun Wen, Jiping Li, Defu Cai, Liling Yue et autres

Shikonin (SHK) has been proven to have a good anti-tumor effect. However, poor water solubility and low bioavailability limit its wide application in clinical practice. In this study, to overcome these drawbacks, RGD-modified shikonin-loaded liposomes (RGD-SSLs-SHK) were successfully prepared. It exhibited excellent …

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The Influence of Corn Silk Polysaccharide on Signal Pathway of TGF-β1 in Type 2 Diabetic Mellitus Rat

Xianchun Wen, Liling Yue

In prevention stage, comparing with normal control group, triglycerides, blood sugar (BG), 24-hour urinary protein and cholesterol (CHO) were higher in T2DM group, but weight and urea nitrogen (BUN) was less in it. 24-hour urinary protein and cholesterol (CHO) were higher in …

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A polysaccharide from Agaricus blazei attenuates tumor cell adhesion via inhibiting E-selectin expression

Liling Yue, Hongxia Cui, Chengchong Li, Yu Lin et autres

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Structural elucidation of a heteroglycan from the fruiting bodies of Agaricus blazei Murill

Jicheng Liu, Chunjing Zhang, Yajun Wang, Haitao Yu et autres

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Effect of stigma maydis aqueous extract on glucolipid metabolism and oxidative stress in type 2 diabetic rats.

Xianchun Wen, Li Zhou, Xiao‐Ming Li

Objective To investigate the effect of stigma maydis aqueous extract on glucolipid metabolism and oxidative stress in type 2 diabetic rats.Methods Male Sprague-Dawley rats were randomly divided into normal control group,model control group,positive control group(Metformin) and stigma maydis aqueous extract low,middle,high dose …