Jens Præstgaard

Continuous Digital Monitoring of Walking Speed in Frail Elderly Patients: Noninterventional Validation Study and Longitudinal Clinical Trial (Data for interventional clinical trial)

Ieuan Clay, Arne Mueller, Daniel Rooks, Sophie Brachat et autres

Digital technologies and advanced analytics have drastically improved our ability to capture and interpret health relevant data from patients. However, to date, limited data and results have been published detailing real-world patient compliance, demonstrating accuracy in target indications or examining what novel …

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Author Correction: Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device

Cameron Kirk, Arne Küderle, M. Encarna Micó-Amigo, Tecla Bonci et autres

The original version of this Article contained an error in Figure 7 where an incorrect reference was cited for one of the recommended algorithms for Gait Speed Detection (GSD). The original Figure 7 and accompanying legend appear below. Figure 7 Overview over …

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Random Effects Meta-Analysis of Contingency Tables with Complete and Partially Complete Data, with Application to COVID-19 Research

Amy Racine-Poon, Jens Præstgaard, Oleksandr Sverdlov

We present a random effects meta-analytic approach for analyzing exchangeable 2×2×2tables of COVID-19 deaths classified by two comorbidities, for example, diabetes and hypertension. We take the marginal tables of comorbidities as multinomial with table-specific cell probabilities drawn from a Dirichlet distribution. Conditionally …

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Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device

Cameron Kirk, Arne Küderle, M. Encarna Micó-Amigo, Tecla Bonci et autres

This study aimed to validate a wearable device's walking speed estimation pipeline, considering complexity, speed, and walking bout duration. The goal was to provide recommendations on the use of wearable devices for real-world mobility analysis. Participants with Parkinson's Disease, Multiple Sclerosis, Proximal …

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Pharmacokinetics and Pharmacodynamics of Bimagrumab (BYM338)

Olivier Pétricoul, Arman Nazarian, Uwe Schuehly, Olivier J. David et autres

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Multimodal data collection in Alzheimer’s disease: Participant acceptance of various digital technologies employed in the MEDIA study

Jennifer Sorinas, Jelena Curcic, Vanessa Vallejo, Oleksandr Sverdlov et autres

Abstract Background The rate of failed drug trials in Alzheimer’s disease (AD) remains high. Many conventional endpoints currently used to demonstrate success of clinical trials lack sensitivity to drug treatment effects and perform disparately across disease stages. These endpoints tend to be …

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Description of the Method for Evaluating Digital Endpoints in Alzheimer Disease Study: Protocol for an Exploratory, Cross-sectional Study

Jelena Curcic, Vanessa Vallejo, Jennifer Sorinas, Oleksandr Sverdlov et autres

BACKGROUND: More sensitive and less burdensome efficacy end points are urgently needed to improve the effectiveness of clinical drug development for Alzheimer disease (AD). Although conventional end points lack sensitivity, digital technologies hold promise for amplifying the detection of treatment signals and …

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VALIDITY AND RELIABILITY OF A BODY-WORN BIOMECHANICAL SENSOR PLATFORM FOR GAIT ANALYSIS

Rob Argent, Alan Kevin Bourke, Martín Brom, B. Caulfield et autres

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Digital endpoints for self‐administered home‐based functional assessment in pediatric Friedreich’s ataxia

Arne Mueller, Elaine Paterson, Avery McIntosh, Jens Præstgaard et autres

BACKGROUND: Friedreich's ataxia is an inherited, progressive, neurodegenerative disease that typically begins in childhood. Disease severity is commonly assessed with rating scales, such as the modified Friedreich's Ataxia Rating Scale, which are usually administered in the clinic by a neurology specialist. OBJECTIVE: …

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POS0020 EFFICACY AND SAFETY OF SECUKINUMAB IN PATIENTS WITH ROTATOR CUFF TENDINOPATHY: A 24-WEEK, RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE II PROOF-OF-CONCEPT TRIAL

Neal L. Millar, Iain B. McInnes, Linda Mindeholm, Abdelkader Seroutou et autres

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POS0277 ANABOLIC EFFECT OF LNA043, A NOVEL DISEASE-MODIFYING OSTEOARTHRITIS DRUG CANDIDATE: RESULTS FROM AN IMAGING-BASED PROOF-OF-CONCEPT TRIAL IN PATIENTS WITH FOCAL ARTICULAR CARTILAGE LESIONS

Siegfried Trattnig, Celeste Scotti, Didier Laurent, Scott A. Hacker et autres

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A Study of Novel Exploratory Tools, Digital Technologies, and Central Nervous System Biomarkers to Characterize Unipolar Depression

Oleksandr Sverdlov, Jelena Curcic, Kristín Hannesdóttir, Liangke Connie Gou et autres

Background: Digital technologies have the potential to provide objective and precise tools to detect depression-related symptoms. Deployment of digital technologies in clinical research can enable collection of large volumes of clinically relevant data that may not be captured using conventional psychometric questionnaires …

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