Karsten Ruscher

A Dynamic and Complex Early Inflammatory Response in Blood and Cerebrospinal Fluid of Severe Traumatic Brain Injury Patients: A Dual Platform Analysis

Oskar Persson, Karsten Ruscher, Erik Uvelius, Niklas Marklund

Severe traumatic brain injury (TBI) is associated with high mortality and long-term disability. Inflammation is central to TBI pathophysiology, yet early dynamics of inflammatory mediators in blood and cerebrospinal fluid (CSF) remain incompletely understood, and commonly used assay platforms have rarely been …

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Age- and sex-dependent differences in white matter pathology in the chronic phase of diffuse traumatic brain injury in the mouse

Georgios Michalettos, Karsten Ruscher, Niklas Marklund

Traumatic brain injury (TBI) is commonly associated with white matter injury, leading to persistent symptoms and long-term disability. While advanced age is linked to worse outcome post-TBI, the influence of sex remains highly controversial. The present study aimed to identify age- and …

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Environmental enrichment modulates chronic poststroke inflammation and links white matter TREM2‐positive microglia in recovery in mice

Lluís Camprubí‐Ferrer, Ömer K. Kolbay, Miriana Jlenia Quattromani, Tadeusz Wieloch et autres

Abstract Background Environmental enrichment (EE) has been widely reported to improve functional recovery after stroke, yet its effects on chronic inflammation and white matter pathology remain less well defined. The aim of this study was to investigate whether poststroke EE modulates chronic …

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Targeted Inhibition of mGlu5 Receptors in the Contralesional Hemisphere Improves Functional Recovery After Stroke

Federica Mastroiacovo, Serena Notartomaso, Slovianka Moyanova, Amadeu Llebaria et autres

BACKGROUND: Understanding circuit-level changes that either enhance or impair the brain's capacity for recovery will inform the design of more specific, targeted interventions to enhance recovery from stroke. We previously reported that pharmacological blockade of mGlu5 (type-5 metabotropic glutamate) receptors improves recovery …

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Persistent increase of Nogo-A-positive cells and dynamic reduction in oligodendroglia lineage cells in white matter regions following experimental and clinical traumatic brain injury

Karsten Ruscher, Georgios Michalettos, Sami Abu Hamdeh, Fredrik Clausen et autres

White matter (WM) disruption and atrophy is a consequence of traumatic brain injury (TBI) and contributes to persisting cognitive impairment. An increased expression of the myelin-associated axonal outgrowth inhibitor Nogo-A and oligodendrocyte pathology might be negatively associated with postinjury WM changes. Here, …

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Traumatic brain injury causes early aggregation of beta-amyloid peptides and NOTCH3 reduction in vascular smooth muscle cells of leptomeningeal arteries

Ílknur Özen, Sami Abu Hamdeh, Karsten Ruscher, Niklas Marklund

Abstract Traumatic brain injury (TBI) often leads to impaired regulation of cerebral blood flow, which may be caused by pathological changes of the vascular smooth muscle cells (VSMCs) in the arterial wall. Moreover, these cerebrovascular changes may contribute to the development of …

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A Dynamic and Robust Neuroinflammation in Blood and CSF of Severe Traumatic Brain Injury Patients: A Dual Platform Analysis

Oskar Persson, Karsten Ruscher, Erik Uvelius, Niklas Marklund

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Increased Inflammatory Biomarkers in CSF in Degenerative Cervical Myelopathy Patients

Christian Brandt, Henrietta Nittby Redebrandt, Karsten Ruscher, Gregor Tomasevic et autres

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Complement Inhibition in Chronic Subdural Hematoma Fluid

Niklas Marklund, Shaian Zolfaghari, Gustaf Westerberg, Karsten Ruscher et autres

BACKGROUND: Emerging data suggest a complex pathophysiology of chronic subdural hematoma (CSDH) to which an inflammatory response might contribute. The complement system is activated in acute traumatic setting, although its role in CSDH is unknown. To investigate the complement system in CSDH …

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Impaired oligodendrogenesis in the white matter of aged mice following diffuse traumatic brain injury

Georgios Michalettos, Fredrik Clausen, Ílknur Özen, Karsten Ruscher et autres

Senescence is a negative prognostic factor for outcome and recovery following traumatic brain injury (TBI). TBI-induced white matter injury may be partially due to oligodendrocyte demise. We hypothesized that the regenerative capacity of oligodendrocyte precursor cells (OPCs) declines with age. To test …

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Activation of dopamine 2 receptors modulates glutamate decarboxylases 65 and 67 during stroke recovery in mice

Daniela Talhada, Robert Nilsson, Severin Walser, Georgios Michalettos et autres

Backgrounds: Treatment with levodopa enhances recovery of lost neurological functions in preclinical stroke models and patients. Here, we studied whether dopamine signaling modulates GABAergic neurotransmission in parvalbumin-positive interneurons after experimental stroke. Methods: Following block randomization, mice were subjected to experimental stroke induced …

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Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI)

Jie Liu, Heleen van Beusekom, Xian‐Le Bu, Gong Chen et autres

The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease (AD) and associated socioeconomic burdens. Abnormal metabolism of amyloid-β (Aβ) has been proposed as a significant pathomechanism in AD, supported by results of recent clinical …

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