Mae Chester‐Jones

Liraglutide in mild to moderate Alzheimer’s disease: a phase 2b clinical trial

Paul Edison, Grazia Daniela Femminella, Craig Ritchie, Joseph Nowell et autres

Liraglutide, a glucagon-like peptide 1 (GLP-1) agonist and antidiabetic drug, has shown neuroprotective effects in animal models. In this study, we aimed to evaluate the safety and efficacy of liraglutide in mild to moderate Alzheimer's disease syndrome. 'Evaluating liraglutide in Alzheimer's disease' …

gb, cn, dk, nl (code pays fourni par la source)

Clinical prediction models using machine learning in oncology: challenges and recommendations

Professor Gary S. Collins, Mae Chester‐Jones, Stephen Gerry, Jie Ma et autres

Clinical prediction models are widely developed in the field of oncology, providing individualised risk estimates to aid diagnosis and prognosis. Machine learning methods are increasingly being used to develop prediction models, yet many suffer from methodological flaws limiting clinical implementation. This review …

gb (code pays fourni par la source)

Maternal early warning scores shown to be methodologically weak and at high risk of bias

Mae Chester‐Jones, Shona Kirtley, Fema Er, Vidoushee Jogarah et autres

OBJECTIVES: To systematically review and critically appraise the methodology of developing modified obstetric early warning scores (MOEWSs). STUDY DESIGN AND SETTING: We searched Medline, CINAHL, EMBASE, and the Web of Science for MOEWS studies published between January 1, 2000, and December 31, …

gb (code pays fourni par la source)

UKRN Local Network Lead Guidebook

Reproducibility Network, Samuel James Westwood, Diane L. Hird, Nick Ballou et autres

A short guidebook developed by UKRN Local Network Leads (LNLs) to enable new and current LNLs to understand their role, plan objectives and activities, and be aware of the many benefits of being an LNL.

gb (code pays fourni par la source)

Would I lie to you? The open scholarship edition

Mae Chester‐Jones, Gaurav Vivek Bhalerao, M. Brouard, C Rahal et autres

The format – borrowing from the popular television show of the same name – involves members from Reproducible Research Oxford (‘RROx’) and invited speakers telling arange of ‘Data Horror Stories’. These stories – invariably from personal experiences –involve nightmarish academic anecdotes where …

gb (code pays fourni par la source)

UKRN Local Network Lead Guidebook

Samuel James Westwood, Diane L. Hird, Nick Ballou, Michel Belyk et autres

A short guidebook developed by UKRN Local Network Leads (LNLs) to enable new and current LNLs to understand their role, plan objectives and activities, and be aware of the many benefits of being an LNL.

gb (code pays fourni par la source)

Reporting completeness of nutrition and diet-related randomised controlled trials protocols

Flávia Moraes Silva, Amanda Rodrigues Amorim Adegboye, Cíntia Chaves Curioni, Fábio da Silva Gomes et autres

gb, br, us, ae, au, fr, Afrique du Sud, ca (code pays fourni par la source)

Development of a national maternity early warning score: centile based score development and Delphi informed escalation pathways

Stephen Gerry, Jonathan Bedford, Oliver Redfern, Hannah Rutter et autres

Objective: To derive a new maternity early warning score (MEWS) from prospectively collected data on maternity vital signs and to design clinical response pathways with a Delphi consensus exercise. Design: Centile based score development and Delphi informed escalation pathways. Setting: Pregnancy Physiology …

gb (code pays fourni par la source)

MRI CHANGES FOLLOWING TREATMENT OF GLP‐1 ANALOGUE, LIRAGLUTIDE IN ALZHEIMER’S DISEASE

Paul Edison, Grazia Daniela Femminella, Craig Ritchie, Joseph Nowell et autres

Abstract Background Preclinical evidence in transgenic models of Alzheimer’s disease (AD) suggests that liraglutide, a GLP1 analogue, exerts neuroprotective effects by reducing amyloid oligomers, normalising synaptic plasticity and reducing insulin resistance, and increasing the proliferation of neuronal progenitor cells. ELAD is a …

gb, us, de, cn, nl (code pays fourni par la source)

Early Video-assisted Thoracoscopic Surgery or Intrapleural Enzyme Therapy in Pleural Infection: A Feasibility Randomized Controlled Trial. The Third Multicenter Intrapleural Sepsis Trial—MIST-3

Eihab O. Bedawi, Dionisios Stavroulias, Emma L. Hedley, Kevin G. Blyth et autres

Abstract Rationale Assessing the early use of video-assisted thoracoscopic surgery (VATS) or intrapleural enzyme therapy (IET) in pleural infection requires a phase III randomized controlled trial (RCT). Objectives To establish the feasibility of randomization in a surgery-versus-nonsurgery trial as well as the …

gb, is, us, cn, fr, in, au, Égypte (code pays fourni par la source)

The clinical and cost effectiveness of surgical repair of partial rotator cuff tears in patients with subacromial shoulder pain: a comparison of surgical repair versus surgery with no repair. Partial Rotator Cuff Repair Trial (PRoCuRe Trial)

Jonathan Lloyd Rees, Andrew Jonathan Carr, Jonathan Alistair Cook, Amar Rangan et autres

The clinical and cost effectiveness of surgical repair of partial rotator cuff tears in patients with subacromial shoulder pain: a comparison of surgical repair versus surgery with no repair. Partial Rotator Cuff Repair Trial (PRoCuRe Trial) Jonathan Rees1*, Andrew Carr1, Jonathan Cook1, …

gb (code pays fourni par la source)

Is it feasible to treat painful hand osteoarthritis with menopausal hormonal treatment? Results from a randomised controlled trial (the HOPE-e study)

Jennifer A. E. Williams, Mae Chester‐Jones, Gretchen Brewer, Anne B. Francis et autres

gb (code pays fourni par la source)