Ian S. Goldlust

Abstract 6718: Identifying new cell surface markers of T-cell reactivity through single cell transcriptomic analysis

Abraham A. Hakim, Lisa M. Kenney, Nivedita M. Ratnam, Jared J. Gartner et autres

Abstract Background: Adoptive transfer of selected tumor infiltrating lymphocytes (SEL-TIL)+ pembrolizumab has yielded clinical responses of 23.5% in a phases 2 trial.1 Following expansion in IL-2, TIL cultures are selected for treatment based on in vitro reactivity assays in which TIL are …

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Prenatal cfDNA Sequencing and Incidental Detection of Maternal Cancer

Amy E. Turriff, Christina M. Annunziata, Ashkan Akhavan Malayeri, Bernadette A. Redd et autres

(Abstracted from N Engl J Med 2024;391:2123–132 The sequencing of circulating cell-free DNA (cfDNA) has become a routine part of prenatal screening for fetal aneuploidy. Its use has reduced the use of perhaps 70% of diagnostic procedures, such as amniocentesis, worldwide.

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Prenatal Cell-Free DNA Sequencing and Intrahepatic Cholangiocarcinoma

Ian S. Goldlust, Michael V. Gormally, Sara Teichholtz, Amy E. Turriff et autres

Prenatal cell-free DNA (cfDNA) sequencing is a screening method that utilizes circulating cfDNA in maternal blood to identify fetal chromosomal abnormalities. Beyond its primary application in prenatal care, cfDNA sequencing can detect occult maternal malignancies before they manifest clinically, presenting a critical …

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Prenatal Cell-free DNA Sequencing and Incidental Detection of Maternal Cancer

AE Turriff, Christina M. Annunziata, Ashkan Akhavan Malayeri, Bernadette A. Redd et autres

(N Engl J Med. 2024;391(22):2123–2132. doi: 10.1056/NEJMoa2401029) The study investigates the incidental detection of maternal cancer through prenatal cell-free DNA (cfDNA) sequencing, which is primarily used for screening fetal aneuploidy. The unexpected discovery of maternal malignancy through cfDNA sequencing results prompted the …

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Publisher Correction: Neoantigen-specific tumor-infiltrating lymphocytes in gastrointestinal cancers: a phase 2 trial

Frank J. Lowery, Stephanie L. Goff, Billel Gasmi, Maria R. Parkhurst et autres

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Neoantigen-specific tumor-infiltrating lymphocytes in gastrointestinal cancers: a phase 2 trial

Frank J. Lowery, Stephanie L. Goff, Billel Gasmi, Maria R. Parkhurst et autres

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Incidental Detection of Maternal Cancer Following Cell-Free DNA Screening for Fetal Aneuploidies

Ian S. Goldlust, Diana W. Bianchi

BACKGROUND: Prenatal cell-free DNA (cfDNA) screening is a success story of clinical genomics that has translated to and transformed obstetric care. It is a highly sensitive and specific method of screening for the most common fetal aneuploidies, including trisomies 13, 18, and …

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Prenatal cfDNA Sequencing and Incidental Detection of Maternal Cancer

Amy E. Turriff, Christina M. Annunziata, Ashkan Akhavan Malayeri, Bernadette A. Redd et autres

BACKGROUND: Cell-free DNA (cfDNA) sequence analysis to screen for fetal aneuploidy can incidentally detect maternal cancer. Additional data are needed to identify DNA-sequencing patterns and other biomarkers that can identify pregnant persons who are most likely to have cancer and to determine …

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Primary culture of high grade serous ovarian cancer cells, selection and derivation of three cell lines

James D. Brenton, Maria Vias, Carolin M. Sauer, Gabriel Funingana et autres

Cell line models for high grade serous ovarian cancer (HGSOC) are limited in number and are poorly clinically annotated. Consequently, existing models often fail to recapitulate common features of HGSOC, inhibiting mechanistic and therapeutic discovery. We generated and characterised three spontaneously immortalized …

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PARP inhibitors in ovarian cancer

Ian S. Goldlust, Elena Guidice, Jung‐Min Lee

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The spectrum of cell death in sarcoma

Elizaveta D. Belyaeva, Nina Loginova, Ian S. Goldlust, Arbind Acharya et autres

The balance between cell death and cell survival is a highly coordinated process by which cells break down and remove unnecessary or harmful materials in a controlled, highly regulated, and compartmentalized manner. Cell exposure to various stresses, such as oxygen starvation, a …

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Data from Type I Cytokines Synergize with Oncogene Inhibition to Induce Tumor Growth Arrest

Nicolas Acquavella, David C. Clever, Zhiya Yu, Melody Roelke‐Parker et autres

Abstract Both targeted inhibition of oncogenic driver mutations and immune-based therapies show efficacy in treatment of patients with metastatic cancer, but responses can be either short lived or incompletely effective. Oncogene inhibition can augment the efficacy of immune-based therapy, but mechanisms by …

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