Wilbert P. Vermeij

Warburg metabolic states are heterogeneous and frequent in pediatric hematological malignancies

Ziqin Tang, Pleun M.J. van de Water, Kimberly Smit, Rutger A. Ozinga et autres

Background Enhanced aerobic glycolysis in cancer is commonly known as the Warburg effect. Clinically, Warburg metabolism has been associated with poor prognosis and therapy resistance in multiple cancer types, and this metabolic shift has been well-documented in adult cancer patients. Nevertheless, combined …

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Prestin as a potential biomarker for cochlear injury: Current evidence and future directions

Nienke Streefkerk, Regina Timmer, Alice I. E. Larsson, Kim E. de Jager et autres

PURPOSE: Prestin has been identified as a potential biomarker for cochlear damage and consequent ototoxicity. Although several preclinical and clinical studies have investigated prestin, a comprehensive overview of the evidence regarding its diagnostic value across different types of auditory damage and its …

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Short-term fasting protects healthy kidney tissue against therapeutic damage: Towards better recovery and limiting side-effects in children with cancer

Daphne S. J. Komninos, Marry M. van den Heuvel-Eibrink, Janine Hoeijmakers, Wilbert P. Vermeij

Cancer treatments like chemotherapy have greatly improved survival rates, especially in children, but often cause serious long-term side effects that impact quality of life. This thesis explores whether short-term fasting (STF) can help protect healthy tissues and reduce these effects. We studied …

TEMPORAL PROFILING OF OSTEOARTHRITIC SYNOVIAL FLUID-INDUCED TRANSCRIPTOMIC CHANGES IN CHONDROCYTES

Ivar van Galen, Marjolein Caron, Rutger Ozinga, Marjolein de Vries et autres

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Consistent changes in global gene expression patterns despite strong variation in individual gene expression in the male mouse hippocampus following early life stress

Jeniffer Sanguino-Gómez, Jacobus C. Buurstede, Eduardo H.L. Umeoka, Marcia Santos da Silva Umeoka et autres

Exposure to excessive and/or chronic stressors during early life is a well-established risk factor for later life stress-related mood disorders. Glucocorticoids are often implied as mediators of the long-term effects of early life stress (ELS), given their powerful transcriptional effects via the …

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CAR-mediated release of IL-10 increases the function of regulatory T cells: Relevance for future clinical application

Adeel Saleem, Peng Qi, Ziqin Tang, Yasmin R. Mohseni et autres

Regulatory T cell (Treg) therapy emerges for various indications associated with a breakdown of immune tolerance. Antigen-specific chimeric antigen receptor (CAR) Tregs are frontrunners for transplantation and autoimmune diseases and are currently being clinically evaluated. We aimed to link CAR-antigen engagement with …

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Translational Changes upon Aging and Dietary Restriction in Progeroid DNA-Repair-Deficient Mice

Wilbert P. Vermeij, Ivar van Galen, Rutger A. Ozinga, Damon A. Hofman et autres

Aging is a complex multifactorial phenomenon largely driven by damaged macromolecules.We showed recently that with aging, time-and exposure-dependent accumulation of DNA damage derails the basal process of transcription, physically stalling RNA polymerase, lowering and skewing the transcriptional landscape in a gene-length-dependent fashion.However, …

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The Use of Nutritional Interventions to Enhance Genomic Stability in Mice and Delay Aging

Ivar van Galen, Jan H.J. Hoeijmakers, Wilbert P. Vermeij

Background/Objectives: Metabolism is fundamental to all living organisms. It comprises a highly complex network of fine-tuned chemical reactions that sustain life but also generate by-products that damage cellular biomolecules, including DNA, thereby contributing to aging and disease. As metabolism can be largely …

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The Role of DNA Damage and Nutritional Interventions in Aging in Progeroid Mice

Ivar van Galen, Leendert H. J. Looijenga, J.H.J. Hoeijmakers, Wilbert P. Vermeij et autres

The global shift toward an aging population brings both opportunities and challenges. Older individuals provide valuable caregiving and experience, yet aging increases vulnerability to diseases such as cancer, neurodegeneration, and sarcopenia, creating economic and healthcare pressures. At the cellular level, aging reflects …

Preoperative short-term fasting in paediatric cancer care is safe, feasible and activates protective responses

Daphne S. J. Komninos, Christiaan A. J. Oudmaijer, Rutger A. Ozinga, Kevin M. Smit et autres

Background Paediatric cancer patients often face treatment-induced complications significantly affecting Quality of Life. Short-term fasting (STF) could mitigate therapy-related adverse toxicity by triggering a protective survival response. While STF and other nutritional interventions have shown clinical benefits in adults, application in paediatric …

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Correction of pathogenic mitochondrial DNA in patient-derived disease models using mitochondrial base editors

Indi P. Joore, Sawsan Shehata, Irena Muffels, Jose Castro-Alpízar et autres

Mutations in the mitochondrial genome can cause maternally inherited diseases, cancer, and aging-related conditions. Recent technological progress now enables the creation and correction of mutations in the mitochondrial genome, but it remains relatively unknown how patients with primary mitochondrial disease can benefit …

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High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and accelerates ageing in progeroid DNA repair-deficient mice

Ivar van Galen, María Björk Birkisdóttir, Rutger A. Ozinga, Renata M. C. Brandt et autres

DNA-repair-deficient mice, which are an excellent model for accelerated ageing and are hyperresponsive to the anti-ageing effect of dietary restriction. Restricting dietary protein by 50% extended lifespan in male mice, but not in females. Restricting protein levels beyond 80% improved various neurological …

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