Anne Szarewski

COCs and VTE risks

Anne Szarewski, Consultant in Community Gynaecology Diana Mansour

Risk of VTE with COCs containing different progestogens

Anne Szarewski, Consultant in Community Gynaecology Diana Mansour

Genotyping for Human Papillomavirus Types 16 and 18 in Women With Minor Cervical Lesions

Marc Arbyn, Lan Xu, Freija Verdoodt, Jack Cuzick et autres

BACKGROUND: High-risk human papillomavirus (hrHPV) testing to triage women with minor cervical lesions generates many referrals. PURPOSE: To evaluate the accuracy of genotyping for HPV types 16 and 18 and its utility as a second triage step after hrHPV testing in women …

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A comparison of different human papillomavirus tests in PreservCyt versus SurePath in a referral population—PREDICTORS 4

Jack Cuzick, Amar Ahmad, Janet Austin, Louise Cadman et autres

BACKGROUND: Two transport media, PreservCyt and SurePath, are widely used for cervical cytology screening. There are concerns that they may perform differently for HPV testing. OBJECTIVES: A comparison of the performance of six different HPV tests in SurePath and PreservCyt in a …

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Efficacy of Human Papillomavirus 16 and 18 (HPV-16/18) AS04-Adjuvanted Vaccine against Cervical Infection and Precancer in Young Women: Final Event-Driven Analysis of the Randomized, Double-Blind PATRICIA Trial

Dan Apter, Cosette M. Wheeler, Jorma Paavonen, Xavier Castellsagué et autres

We report final event-driven analysis data on the immunogenicity and efficacy of the human papillomavirus 16 and 18 ((HPV-16/18) AS04-adjuvanted vaccine in young women aged 15 to 25 years from the PApilloma TRIal against Cancer In young Adults (PATRICIA). The total vaccinated …

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A randomized controlled trial in non-responders from Newcastle upon Tyne invited to return a self-sample for Human Papillomavirus testing versus repeat invitation for cervical screening

Louise Cadman, Scott Wilkes, Diana Mansour, Janet Austin et autres

BACKGROUND: Non-attenders for cervical screening are at increased risk of cervical cancer. Studies offering self-sampling for high-risk Human Papillomavirus (HrHPV) testing have shown greater uptake than sending another invitation for cytology. OBJECTIVES: To explore whether uptake would increase in a less diverse, …

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Risk of first cervical HPV infection and pre-cancerous lesions after onset of sexual activity: analysis of women in the control arm of the randomized, controlled PATRICIA trial

Xavier Castellsagué, Jorma Paavonen, Unnop Jaisamrarn, Cosette M. Wheeler et autres

BACKGROUND: More information is needed about time between sexual initiation and human papillomavirus (HPV) infection and development of cervical precancer. METHODS: The objectives were to investigate the time between first sexual activity and detection of first cervical HPV infection or development of …

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Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 4-year interim follow-up of the phase 3, double-blind, randomised controlled VIVIANE study

S. Rachel Skinner, Anne Szarewski, Barbara Romanowski, Suzanne M. Garland et autres

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Risk of Newly Detected Infections and Cervical Abnormalities in Women Seropositive for Naturally Acquired Human Papillomavirus Type 16/18 Antibodies: Analysis of the Control Arm of PATRICIA

Xavier Castellsagué, Paulo Naud, Song-Nan Chow, Cosette M. Wheeler et autres

BACKGROUND: We examined risk of newly detected human papillomavirus (HPV) infection and cervical abnormalities in relation to HPV type 16/18 antibody levels at enrollment in PATRICIA (Papilloma Trial Against Cancer in Young Adults; NCT00122681). METHODS: Using Poisson regression, we compared risk of …

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A DNA methylation classifier of cervical precancer based on human papillomavirus and human genes

Adam R. Brentnall, Nataša Vasiljević, Dorota Scibior‐Bentkowska, Louise Cadman et autres

Testing for high-risk (hr) types of human papillomavirus (HPV) is highly sensitive as a screening test of high-grade cervical intraepithelial neoplastic (CIN2/3) disease, the precursor of cervical cancer. However, it has a relatively low specificity. Our objective was to develop a prediction …

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Individual detection of 14 high risk human papilloma virus genotypes by the PapType test for the prediction of high grade cervical lesions

Jack Cuzick, Linda Ho, George Terry, Michelle Kleeman et autres

BACKGROUND: HR HPV genotypes when assayed collectively, achieve high sensitivity but low specificity for the prediction of CIN2+. Knowledge of the specific genotypes in an infection may facilitate the use of HR HPV detection in routine clinical practice. OBJECTIVES: To compare the …

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Attitudes towards cytology and human papillomavirus self-sample collection for cervical screening among Hindu women in London, UK: a mixed methods study

Louise Cadman, Lesley Ashdown-Barr, Jo Waller, Anne Szarewski

OBJECTIVES: To explore the attitudes, views and understanding of women attending a Hindu temple in London, UK towards cervical screening, human papillomavirus (HPV) testing and two HPV self-sample collection devices: the Dacron swab and Evalyn(®) brush. METHODS: A mixed methods design comprising …

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