Jiaqi Zhou

AI-guided discovery of a novel ATP/ADP binding domain in plant HAK transporters that regulates K+/Na+ homeostasis

Fan Yang, Qinrui Wang, Junzhao Yang, Ruoxian Xia et autres

Maintaining Na+/K+ homeostasis is fundamental for plant environmental adaptation. Using domain classification of plant Na+/K+ transport proteins, and AI-based ligand screening integrated with biochemical characterization, we identified a previously unannotated cytoplasmic domain (CPD) in plant HAKs as a novel ATP/ADP-binding fold. We …

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Structural basis for the activity regulation of Medicago calcium channel CNGC15

Xia Xu, Qinrui Wang, Tengfei Sun, Ruichu Gu et autres

Abstract Cyclic nucleotide-gated ion channels (CNGCs) in plants mediate Ca 2+ influx in response to environmental changes. Among numerous plant CNGCs, Medicago truncatula CNGC15a/b/c ( Mt CNGC15) is localized to the nuclear envelope. The opening and closing cycle of Mt CNGC15 is …

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Muti-omics insights the enhancement of drought tolerance in sweet cherry with dark septate endophyte S16

Qianxi Pang, Dehui Qu, Wenfei Li, Jiaqi Zhou et autres

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Structural insights into the Oryza sativa cation transporters HKTs in salt tolerance

R. X. Gao, Yutian Jia, Xia Xu, Peng Fu et autres

ABSTRACT The high‐affinity potassium transporters (HKTs), selectively permeable to either Na+ alone or Na+/K+, play pivotal roles in maintaining plant Na+/K+ homeostasis. Although their involvement in salt tolerance is widely reported, the molecular underpinnings of Oryza sativa HKTs remain elusive. In this …

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Structural changes in the conversion of an Arabidopsis outward-rectifying K+ channel into an inward-rectifying channel

Xudong Gao, Xia Xu, Tengfei Sun, Yuhan Lu et autres

Potassium transport mechanisms are pivotal for plant development and stress responses. Here, we elucidate the structural and functional dynamics of the plant K+ outward rectifier channel SKOR and a double-mutations variant (SKDM) that changes the channel into an inward rectifier one. This …

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Structural basis for the activity regulation of Salt Overly Sensitive 1 in Arabidopsis salt tolerance

Yanming Zhang, Jiaqi Zhou, Xuping Ni, Qinrui Wang et autres

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Clinical Application of a Modified Local Transposition Flap (Parallelogram Flap) Surgery in Repairing Fingertip Defects

Yingkai Zhang, Yao Wang, Jiaqi Zhou, Xianwei He et autres

OBJECTIVE: Parallelogram flap was performed for transverse finger amputation with the loss of distal pulp, nails, and bone. This study aimed to compare the clinical effects of parallelogram flap, antegrade homodigital island flaps, and reverse digital artery island flaps in fingertip reconstruction. …

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Parallelogram flap versus homodigital island flap in the treatment of fingertip defects with bone exposure: a prospective controlled study

Yingkai Zhang, Yao Wang, Xianwei He, Jiaqi Zhou et autres

PURPOSE: A modified local transposition flap (we call it "parallelogram flap") surgery was performed for fingertip injuries. This study aimed to compare the clinical effects of parallelogram flap and homodigital island flaps in fingertip reconstruction. METHODS: The study collected patients who underwent …

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Clinical Application of a Modified Local Transposition Flap Surgery in Repairing Fingertip Defects

Yingkai Zhang, Yao Wang, Rongbo Wu, Jiaqi Zhou

Abstract Background: A modified local transposition flap surgery was performed for fingertip injuries, which allows a more significant transfer distance with good outcomes.Methods: The study collected patients who underwent parallelogram transposition flaps and V-Y flaps to repair fingertip defects from 2017 to …

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