Yifei Jiang

Nanoconfined Polymer Dot Reactors for Ultrasensitive Monitoring of Diverse Metabolites and Point-of-Care Diagnosis

Yijun Liu, Peng Zhou, Zitong Yang, Yuxin Yao et autres

Abstract Polymer dots (Pdots) offer high brightness and tunable electronic properties for point-of-care testing, but conventional sensing often suffers from inefficient stochastic interactions and limited adaptability. Here, we screened Pdots for interactions with the NAD+/NADH redox couple and identified PDFDP Pdots with …

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Adipose-cartilage communication via EV-Mito–mtDNA signaling promotes osteoarthritis progression

Cheng Gu, Fawei Liao, Ganggang Kong, Shiyi Yin et autres

Obesity is a major risk factor for osteoarthritis (OA), yet the mechanisms linking excess adiposity to joint degeneration remain incompletely understood. Here, we identify adipocyte-derived extracellular vesicles enriched in mitochondrial components (EV-Mito) as pathogenic mediators that transfer mitochondrial DNA (mtDNA) to chondrocytes. …

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Raman and surface-enhanced Raman spectroscopy for intraoperative cancer diagnostics: sentinel lymph node biopsy, biomarkers and translational challenges

Jiaqi Feng, Chunyan Li, Xiaowei Jiang, Lizhi Zhou et autres

Sentinel lymph node biopsy (SLNB) serves as the gold standard for staging regional lymph node metastasis of solid tumors, which is crucial for guiding clinical treatment decisions and evaluating prognosis. Conventional intraoperative detection methods for SLN, such as frozen section and touch …

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Green space pattern and thermal comfort simulation based on high-resolution remote sensing images

Yifei Jiang, Yuanyuan Hao, Lina Wang, Jiajing He

The green space pattern has obvious impacts on thermal comfort simulation, and clarifying the correlation between the two is crucial for optimizing urban green space planning. To explore the correlation between green space pattern and thermal comfort simulation, a green space pattern …

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LV-CARE-Diff: A Conditional Anatomy-Aware Diffusion Model for Left Ventricular Shape Reconstruction and Function Quantification from Ultra-Sparse Cine Slices

Xinwang Li, Yu Lian, Bowei Liu, Yifei Jiang et autres

Left ventricular functional quantification is an essential examination and is routinely performed using cardiovascular magnetic resonance (CMR) cine imaging. However, conventional CMR cine protocols require the acquisition of multiple short-axis (SAX) slices to cover the entire left ventricle (LV) along with two …

A human iPSC-derived 3D spinal cord organoid model to study radiation-induced neural injury

Yifei Jiang, Xubo Li, Jingguang Zeng, Shiju Chen et autres

BACKGROUND: Radiation therapy remains a cornerstone in the treatment of primary and metastatic tumors; however, its efficacy is limited by the spinal cord's high sensitivity to radiation-induced injury. To better understand the mechanisms underlying spinal cord radiosensitivity, we developed a three-dimensional human …

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Separation-Free Extracellular Vesicle Microribonucleic Acid Profiling Using Structurally Oriented Membrane Fusion and Spatially Confined Amplification

Sihui Tong, Xiaoyi Fu, Lubin Qi, Haixin Wang et autres

High Resolution Image Download MS PowerPoint Slide Current methods for profiling of extracellular vesicle (EV) microRNAs (miRNAs) involve either PCR or sequencing analysis of EV lysate or delivery of RNA probes into EVs for in situ hybridization, which suffer from complex protocols …

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Profiling of Integrin Isoforms on Lung‐Tropic Exosomes by Spectrally and Kinetically Multiplexed Single‐Molecule Imaging

Songlin Liu, Haixin Wang, Qin Shentu, Liang Yuan et autres

Since the first report that integrins on exosomes can potentially dictate their organ-tropic transport, there have been great interest in obtaining a better understanding of this phenomenon. However, integrins have many isoforms, which are heterogeneously distributed among individual exosomes with relatively low …

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Single-chain ultrasmall fluorescent polymer dots enable nanometre-resolution cellular imaging and single protein tracking

Hongwei Yang, Zequan Yan, Xiaolong Liu, Weifeng Liu et autres

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Highly Emissive BODIPY-Grafted Polymer Dots for Cellular and Tissular STED Imaging

Xingxing Yao, Jiantao Ping, Long Chen, Liqing Qi et autres

High Resolution Image Download MS PowerPoint Slide Stimulated emission depletion (STED) microscopy requires fluorescent probes to exhibit high brightness, good photostability, a sensitive optical depletion response, and narrow spectral features. There are great interests in using polymer dots (Pdots) for STED imaging …

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"Smart" Nerves Sprout and Assemble in an Extracellular Matrix‐Based 3D Nerve‐in‐a‐Chip Microfluidic Model

Zilong Rao, Qiting Huang, Yifei Jiang, Zudong Lin et autres

Controlling directional neurite outgrowth and Schwann cell (SC) migration remains critical for nerve regeneration. While 2D anisotropic topographies guide nerve growth via contact guidance, these models fail to recapitulate the 3D extracellular matrix microenvironment of native nerves. Herein, a microfluidic "nerve-in-a-chip" platform …

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Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer

Rui Wang, Yifei Jiang, Fuxiang Chen, Zihan Wang et autres

Background: Pancreatic cancer (PC) is marked by extensive heterogeneity, posing significant challenges to effective treatment. The tumor microenvironment (TME), particularly cancer-associated fibroblasts (CAFs), plays a critical role in driving PC progression. However, the prognostic and functional contributions of distinct CAF subtypes remain …

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