V. Rosen

Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting

Xi Lin, Chloe H. Lee, Ting Zhang, Agne Antanaviciute et autres

The early-life intestinal microenvironment plays a pivotal role in shaping immune cell development. Here, we identify a colonic Wnt4-expressing stromal cell, enriched during early-life, that promotes iNKT cell proliferation via BMP-MAPK signaling. These stromal cells are spatially associated with iNKT cells and …

us, gb, fr (code pays fourni par la source)

An ex vivo appositional growth model to study periosteal activity and associated BMP signaling

Gavin Chen, Jillian Scott, Ana Garcia Castineiras, Laura Gamer et autres

The periosteum is an osteogenic tissue containing periosteal stem and progenitor cells (PSPCs) that form and repair bones. Much is known about how the periosteum regulates fracture repair, but its key role in bone accrual during postnatal growth and adult load-induced formation …

us (code pays fourni par la source)

A closed-loop cell therapy engineered to autonomously secrete Activin A inhibitor protects from fibrodysplasia ossificans progressiva

Pratik Koirala, Ziyu Chen, Mengfan Wu, David E. Maridas et autres

Abstract Engineered cell therapies present an opportunity for endogenous, site-specific production of therapeutic agents. Here we describe a closed-loop cell therapy which secretes an inhibitor of Activin A, ActR2A-Fc, upon exposure to Activin A. We demonstrate in vivo therapeutic efficacy of this …

us (code pays fourni par la source)

Loss of BMPR2 leads to high bone mass due to increased osteoblast activity

Jonathan W. Lowery, Giuseppe Intini, Laura W. Gamer, Sutada Lotinun et autres

Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGFb signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors ACVR2A and ACVR2B bind BMPs and activins but the type …

us, th (code pays fourni par la source)

Construction and Validation of a Novel Pathway Ratio Reporter System (PARRES)

Tyler King, Satoshi Ote, V. Rosen, Jonathan W. Lowery

Loss of BMPR2 Expression in Skeletal Progenitor Cells Reduces Age-Related Bone Loss

Michael S. Eaton, Jordan B. Newby, Aaron M. Hudnall, V. Rosen et autres

Recombinant human bone morphogenetic protein-2 induces a hematopoietic microenvironment in the rat that supports the growth of stem cells.

Jing An, V. Rosen, Karen Cox, Nicole Beauchemin et autres

In the mammalian bone marrow, stromal components support the growth and differentiation of blood cells. To study this complex system, we used a rat model in which ectopic hematopoietic tissue was induced to form after subcutaneous implantation of recombinant human bone morphogenetic …

ca (code pays fourni par la source)

Development of immortalized cells derived from 13DPC mouse limb buds as a system to study the effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) on limb bud cell differentiation.

V. Rosen, J. Capparella, David P. McQuaid, Kristin Cox et autres

hu, ca (code pays fourni par la source)

RADIOSENSITIVITY OF WHITE RATS AFTER CLINICAL RECOVERY FROM ACUTE RADIATION SICKNESS

V. Rosen

In 2 weeks after the clinical recovery of rats from radiation sickness (appearing as a result of irradiation by the dose of 150 r) there was an increase of resistance of the animals to repeated x-ray irradiation by the same dose, to …