Accès ouvert
2025
conference-abstract
OpenAlex
Zachary Hutchins, Robyn Keller, Molly B. Halloran, Colleen Isabelle et autres
Abstract STAT3 activating mutations, present in 40-70% of large granular lymphocytic leukemia (LGLL) patients, are associated with worse prognosis and inferior response to standard therapies. Once activated, STAT3 forms dimers and enters the nucleus to function as a transcription factor, though its …
us
(code pays fourni par la source)
2025
book-chapter
OpenAlex
Kathleen K. McConnell
Accès ouvert
2025
article
OpenAlex
Colleen Isabelle, Amy E Boles, Kathleen K. McConnell, Robyn Keller et autres
Abstract Cutaneous T-Cell Lymphoma (CTCL) is a non-Hodgkin’s lymphoma involving malignant skin-homing T-cells, characterized by variable severity and limited treatment options. Our study shows that patient samples and derived cell lines express CD38 on CTCL cells, and αCD38 antibodies effectively target CD38 …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Jana von Jan, Sanna H. Timonen, Till Braun, Qu Jiang et autres
ABSTRACT: T-prolymphocytic leukemia (T-PLL) is a mature T-cell neoplasm associated with marked chemotherapy resistance and continued poor clinical outcomes. Current treatments, that is, the CD52-antibody alemtuzumab, offer transient responses, with relapses being almost inevitable without consolidating allogeneic transplantation. Recent more detailed concepts …
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(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Nitin Chakravarti, Amy E Boles, Rachel Burzinski, Paola Sindaco et autres
Abstract Dysregulated nuclear-cytoplasmic trafficking has been shown to play a role in oncogenesis in several types of solid tumors and hematological malignancies. Exportin 1 (XPO1) is responsible for the nuclear export of several proteins and RNA species, mainly tumor suppressors. KPT-330, a …
us
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Colleen Isabelle, Amy E Boles, Kathleen K. McConnell, Robyn Keller et autres
Introduction: Cutaneous T-cell lymphoma (CTCL) is a malignancy of mature CD4+ T-cells that primarily affects the skin. Despite a wide variety of topical and systemic therapies for patients, CTCL remains difficult to treat. Because of its high likelihood of relapse and resistance, …
us
(code pays fourni par la source)
2023
article
OpenAlex
Kathleen K. McConnell, Peter Martin, John Paul Leonard
2023
article
OpenAlex
Nitin Chakravarti, Amy E Boles, Paola Sindaco, Colleen Isabelle et autres
Accès ouvert
2023
other
OpenAlex
Bethany L. Mundy-Bosse, Christoph Weigel, Yue-Zhong Wu, Salma B. Abdelbaky et autres
Abstract Extranodal natural killer/T-cell lymphoma (ENKTL) is an aggressive, rare lymphoma of natural killer (NK) cell origin with poor clinical outcomes. Here we used phenotypic and molecular profiling, including epigenetic analyses, to investigate how ENKTL ontogeny relates to normal NK-cell development. We …
Accès ouvert
2023
supplementary-materials
OpenAlex
Bethany L. Mundy-Bosse, Christoph Weigel, Yue-Zhong Wu, Salma B. Abdelbaky et autres
Supplementary Data from Identification and Targeting of the Developmental Blockade in Extranodal Natural Killer/T-cell Lymphoma
Accès ouvert
2023
supplementary-materials
OpenAlex
Bethany L. Mundy-Bosse, Christoph Weigel, Yue-Zhong Wu, Salma B. Abdelbaky et autres
Supplementary Figure from Identification and Targeting of the Developmental Blockade in Extranodal Natural Killer/T-cell Lymphoma
Accès ouvert
2023
supplementary-materials
OpenAlex
Bethany L. Mundy-Bosse, Christoph Weigel, Yue-Zhong Wu, Salma B. Abdelbaky et autres
Supplementary Data from Identification and Targeting of the Developmental Blockade in Extranodal Natural Killer/T-cell Lymphoma