Accès ouvert
2025
article
OpenAlex
Luminiţa Lăbuşcă, Camelia-Mihaela Zară-Dănceanu, Anca Emanuela Minuti, Cristina Stavilă et autres
Osteochondral explants can serve as valuable ex vivo models for investigating joint development and testing therapeutic interventions in osteoarthritis (OA).The incorporation of synovial tissue in coculture settings more closely reproduces the inflammatory milieu characteristic of OA joints; however, no report exists regarding …
ro, as, us
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Accès ouvert
2025
article
OpenAlex
Andrei Nicolae Ceobanu, Mihail‐Gabriel Dimofte, Dragoș Pieptu, Lucian Hriţcu et autres
Colorectal cancer (CRC) is the third most diagnosed cancer globally and the third leading cause of cancer-related deaths. Early-stage CRC treatment consists of a combination of surgery, radiotherapy, and chemotherapy, while advanced CRC remains difficult to manage, most patients will experience disease …
ro, us
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Accès ouvert
2025
erratum
OpenAlex
Crina Tiron, Gabriel Luţa, Mihail Butura, Florin Zugun‐Eloae et autres
The original Article contains an error in Figure 2 . During the preparation of Figure 2 b the image for the condition “4T1_HUVEC_PASMCs_CD-NHF 5%” was erroneously duplicated from the condition “4T1_CD-NHF-5%” in Figure 2 a. Fig. 2 Effect of CD-NHF in 3D …
ro
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Accès ouvert
2025
article
OpenAlex
Fawzy Akad, Cristinel Ionel Stan, Florin Zugun‐Eloae, Sorin Nicolae Peiu et autres
Gastric cancer remains a significant global health burden, with curative treatment relying on surgical resection, typically total or subtotal gastrectomy. However, the procedure frequently triggers acute metabolic and nutritional disturbances that may impact recovery. Objective: This prospective study aimed to investigate whether …
ro
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Accès ouvert
2025
article
OpenAlex
Sorin Nicolae Peiu, Florin Zugun‐Eloae, Bogdan Stoica, Ecaterina Anisie et autres
In obesity, recent research revealed that increased expression of the growth hormone secretagogue receptor (GHSR) in macrophages plays a pivotal role in the development of meta-inflammation, promoting macrophage infiltration and pro-inflammatory polarization. This study aimed to examine the association between GHSR-1a expression …
ro
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Accès ouvert
2024
article
OpenAlex
Fawzy Akad, Bogdan Filip, Cristina Preda, Florin Zugun‐Eloae et autres
Gastric cancer (GC) remains a significant global health concern, ranking as the third leading cause of cancer-related deaths. Malnutrition is common in GC patients and can negatively impact prognosis and quality of life. Understanding nutritional issues and their management is crucial for …
ro
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Accès ouvert
2024
article
OpenAlex
Luminiţa Lăbuşcă, Florin Zugun‐Eloae
Mesenchymal stromal cells (MSCs) hold great promise for tissue regeneration in debilitating disorders. Despite reported improvements, the short-term outcomes of MSC transplantation, which is possibly linked to poor cell survival, demand extensive investigation. Disease-associated stress microenvironments further complicate outcomes. This debate underscores …
ro
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Accès ouvert
2023
article
OpenAlex
Fawzy Akad, Veronica Mocanu, Sorin Nicolae Peiu, Viorel Scripcariu et autres
Individualized gastric cancer (GC) treatment aims at providing targeted therapies that translate the latest research into improved management strategies. Extracellular vesicle microRNAs have been proposed as biomarkers for GC prognosis. Helicobacter pylori infection influences the therapeutic response to and the drivers of …
ro
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2022
article
OpenAlex
Cristian Livadaru, Ștefan Morărașu, Roxana Bargaoanu, Ștefan Iacob et autres
AIM: The aim of this work is to describe a protocol and assess the feasibility of harvesting and analysing the mesocolic apical fragment (MAF) for the presence of central lymph node (LN) metastasis and extra lymphatic free tumour cells in a random …
ro
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Accès ouvert
2020
article
OpenAlex
Crina Tiron, Gabriel Luţa, Mihail Butura, Florin Zugun‐Eloae et autres
Metastatic breast cancer dominates the female cancer-related mortality. Tumour-associated molecules represents a crucial for early disease detection and identification of novel therapeutic targets. Nanomaterial technologies provide promising novel approaches to disease diagnostics and therapeutics. In the present study we extend the investigations …
ro
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Accès ouvert
2020
article
OpenAlex
Adrian Tiron, Irina Ristescu, Paula Alexandra Postu, Crina Tiron et autres
Perioperative factors promoting cancer recurrence and metastasis are under scrutiny. While oxygen toxicity is documented in several acute circumstances, its implication in tumor evolution is poorly understood. We investigated hyperoxia long-term effects on cancer progression and some underlying mechanisms using both in …
ro
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Accès ouvert
2019
article
OpenAlex
Ioana Hristov, Veronica Mocanu, Florin Zugun‐Eloae, Luminiţa Lăbuşcă et autres
BACKGROUND: The adipocyte expansion is a critical process with implications in the pathogenesis of obesity associated metabolic syndrome. Impaired adipogenesis leads to dysfunctional, hypertrophic adipocytes, local inflammation and peripheric insulin resistance. METHODS: We assessed the relationship between the adipogenic differentiation capacity of …
ro
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