Ilse M. Schrover

Assessing differential application of thromboprophylaxis regimes related to risk of pulmonary embolism and mortality in COVID-19 patients through instrumental variable analysis

Linda Nab, Chantal Visser, Bas C. T. van Bussel, Albertus Beishuizen et autres

Thrombotic complications are common in Coronavirus disease 2019 (COVID-19) patients, with pulmonary embolism (PE) being the most frequent. Randomised trials have provided inconclusive results on the optimal dosage of thromboprophylaxis in critically ill COVID-19 patients. We utilized data from the multicentre CAPACITY-COVID …

nl, gb, sa, us, be, pt, ir, il (code pays fourni par la source)

Tailored anticoagulant treatment after a first venous thromboembolism: protocol of the Leiden Thrombosis Recurrence Risk Prevention (L-TRRiP) study - cohort-based randomised controlled trial

Johanna Louise I. Burggraaf, Nienke van Rein, Remy H.H. Bemelmans, Jan Willem van den Berg et autres

INTRODUCTION: Patients with a first venous thromboembolism (VTE) are at risk of recurrence. Recurrent VTE (rVTE) can be prevented by extended anticoagulant therapy, but this comes at the cost of an increased risk of bleeding. It is still uncertain whether patients with …

nl (code pays fourni par la source)

Lupus anticoagulant associates with thrombosis in patients with COVID‐19 admitted to intensive care units: A retrospective cohort study

Tessa Noordermeer, Roger E. G. Schutgens, Chantal Visser, Emma Rademaker et autres

Background: Thrombosis is a frequent and severe complication in patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Lupus anticoagulant (LA) is a strong acquired risk factor for thrombosis in various diseases and is frequently observed in patients …

nl (code pays fourni par la source)

Metabolic consequences of adipose tissue dysfunction

Ilse M. Schrover

This thesis focuses on the consequences of adipose tissue dysfunction (ATD), which is defined as the imbalance of pro- and anti-inflammatory adipocytokines produced by adipose tissue. ATD leads to the development of the metabolic syndrome, cardiovascular diseases and diabetes. Although the quantity …

The relation between body fat distribution, plasma concentrations of adipokines and the metabolic syndrome in patients with clinically manifest vascular disease

Ilse M. Schrover, Yolanda van der Graaf, Wilko Spiering, Frank L.J. Visseren

Introduction We evaluated the relationship between adipokine plasma concentrations and body fat distribution and the metabolic syndrome. Methods In a cohort of 1215 patients with clinically manifest vascular disease the relation between subcutaneous adipose tissue, visceral adipose tissue, waist circumference, body mass …

nl (code pays fourni par la source)

Identifying treatment response to antihypertensives in patients with obesity-related hypertension

Ilse M. Schrover, Jannick A N Dorresteijn, Jodine E. Smits, A.H. Jan Danser et autres

BACKGROUND: In patients with obesity-related hypertension (ORH), reaction to antihypertensive medication is likely influenced by patientcharacteristics. METHODS: Effects of aliskiren, moxonidine and hydrochlorothiazide on 24-h blood pressure (BP) were compared to placebo. Linear mixed effect models were used to analyze the effect …

nl (code pays fourni par la source)

Adipose Tissue Dysfunction: Clinical Relevance and Diagnostic Possibilities

Ilse M. Schrover, Wilko Spiering, Tim Leiner, Frank L.J. Visseren

Adipose tissue dysfunction is defined as an imbalance between pro- and anti-inflammatory adipokines, causing insulin resistance, systemic low-grade inflammation, hypercoagulability, and elevated blood pressure. These can lead to cardiovascular disease and diabetes mellitus type 2. Although quantity of adipose tissue is an …

nl (code pays fourni par la source)

Comparison of a morning polypill, evening polypill and individual pills on LDL-cholesterol, ambulatory blood pressure and adherence in high-risk patients; a randomized crossover trial

Melvin Lafeber, Diederick E. Grobbee, Ilse M. Schrover, Simon Thom et autres

nl, gb, au (code pays fourni par la source)

Feasibility and reproducibility of free fatty acid profiling in abdominal adipose tissue with 1H‐magnetic resonance spectroscopy at 3 T: Differences between lean and obese individuals

Ilse M. Schrover, Tim Leiner, Dennis W. J. Klomp, Jannie P. Wijnen et autres

PURPOSE: To evaluate the feasibility and reproducibility of free fatty acid (FFA) measurement for diagnosing adipose tissue dysfunction by (1)H-magnetic resonance spectroscopy ((1)H-MRS) in different abdominal adipose tissue depots in healthy obese and lean subjects. MATERIALS AND METHODS: Polyunsaturated fatty acids (PUFA), …

nl (code pays fourni par la source)

Differential effects of renin–angiotensin–aldosterone system inhibition, sympathoinhibition and diuretic therapy on endothelial function and blood pressure in obesity-related hypertension

Johannes A N Dorresteijn, Ilse M. Schrover, Frank L.J. Visseren, Peter G Scheffer et autres

OBJECTIVES: The objective of this study is to determine the effects of renin-angiotensin-aldosterone system inhibition, sympathoinhibition and diuretic therapy on endothelial function and blood pressure in obesity-related hypertension. METHODS: A randomized, four-way, double-blind, crossover study in 31 adults with previously untreated obesity-related …

nl, us (code pays fourni par la source)

Peginterferon monotherapy for the treatment of acute hepatitis C in HIV-coinfected patients

Joop E. Arends, Ilse M. Schrover, C. G. Schaar, Tania Mudrikova et autres

In recent years, in Western Europe, the incidence of acute hepatitis C virus (HCV) infection among HIV-infected men who have sex with men is increasing [1–3]. To date, only a small number of clinical trials have been performed and no evidence-based guidelines …

nl, us (code pays fourni par la source)

EUS-Guided Endoscopic Transgastric Necrosectomy in Patients with Infected Necrosis in Acute Pancreatitis

Ilse M. Schrover, Bas L.A.M. Weusten, Marc G. Besselink, Thomas L. Bollen et autres

nl (code pays fourni par la source)