Accès ouvert
2021
article
OpenAlex
Jae Min Cho, Seul‐Ki Park, Rajeshwary Ghosh, Kellsey Ly et autres
Protein quality control mechanisms decline during the process of cardiac aging. This enables the accumulation of protein aggregates and damaged organelles that contribute to age-associated cardiac dysfunction. Macroautophagy is the process by which post-mitotic cells such as cardiomyocytes clear defective proteins and …
us, br
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Accès ouvert
2021
preprint
OpenAlex
Jae Min Cho, Kellsey Ly, Caroline Ramous, Lauren E. Thompson et autres
ABSTRACT AND KEYWORDS There is evidence for a progressive decline of protein quality control mechanisms during the process of cardiac aging. This enables the accumulation of protein aggregates and damaged organelles that contribute to age-associated cardiac dysfunction. Macroautophagy (referred to as autophagy) …
us, br
(code pays fourni par la source)
2020
conference-abstract
OpenAlex
Caroline Ramous, Jae Min Cho, Seul‐Ki Park, Michele Hansen et autres
Macroautophagy is operational during basal conditions to maintain intracellular organelle and protein quality control, but is upregulated during cellular stress (e.g, dynamic exercise) to adapt to changing nutritional and energy demands. We tested the hypothesis that intact endothelial cell (EC) autophagy is …
us
(code pays fourni par la source)
2020
conference-abstract
OpenAlex
Kellsey Ly, Jae Min Cho, Michele Hansen, Caroline Ramous et autres
Evidence exists that a progressive decline of the cellular quality control mechanism called macroautophagy occurs during the process of primary aging. This leads to the accumulation of protein aggregates (i.e., proteotoxicity) that would otherwise be transported to and degraded in the lysosome. …
us
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2019
article
OpenAlex
Jae Min Cho, Caroline Ramous, Maria Sara de Lima Coutinho Mattera, Michele Hansen et autres
Protein aggregates accumulate and organelles become damaged and/or dysfunctional during the process of aging. A progressive loss of the cellular quality control mechanism autophagy contributes to this age‐associated decline in cellular function in many organs. Evidence for an age‐associated repression in cardiac …
us
(code pays fourni par la source)