Andrea Degl’Innocenti

Proteomics characterization of mule milk throughout lactation

Diana Fanelli, Martina Bartolucci, Cristina Lamberti, Duccio Panzani et autres

Cow milk is a widespread food, but several children are allergic to it – chiefly because of adverse reactions to its proteins. Nutritionally valid, hypoallergenic surrogates are highly sought after, and among them donkey milk is prized for its tolerability and human-like …

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Chlorin e6‐Loaded Nanostructured Lipid Carriers Targeted by Angiopep‐2: Advancing Photodynamic Therapy in Glioblastoma (Adv. Healthcare Mater. 2/2025)

Carlotta Pucci, Daniele De Pasquale, Andrea Degl’Innocenti, Margherita Montorsi et autres

Photodynamic Therapy in Glioblastoma Glioblastoma (GBM) is an aggressive brain tumor, difficult to fully eradicate through surgery alone. This work presents an innovative photodynamic therapy approach using chlorin e6 in lipid nanocarriers, specifically targeted to GBM with angiopep-2. A 5-minute, low-power LED …

Chlorin e6‐Loaded Nanostructured Lipid Carriers Targeted by Angiopep‐2: Advancing Photodynamic Therapy in Glioblastoma

Carlotta Pucci, Daniele De Pasquale, Andrea Degl’Innocenti, Margherita Montorsi et autres

Abstract Glioblastoma (GBM) is a highly aggressive brain tumor known for its resistance to standard treatments. Despite surgery being a primary option, it often leads to incomplete removal and high recurrence rates. Photodynamic therapy (PDT) holds promise as an adjunctive treatment, but …

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Proteome Alterations and Nucleosome Activation in Rat Myoblasts Treated with Cerium Oxide Nanoparticles

Andrea Degl’Innocenti, Clarissa Braccia, Giada Graziana Genchi, Nicoletta di Leo et autres

High Resolution Image Download MS PowerPoint Slide Oxidative stress is a widespread causative agent of disease. Together with its general relevance for biomedicine, such a dynamic is recognizably detrimental to space exploration. Among other solutions, cerium oxide nanoparticles (or nanoceria, NC) display …

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Report on a Milking Mule: Milk Qualitative Characteristics during Lactation

Mina Martini, Andrea Degl’Innocenti, Iolanda Altomonte, Irene Sodi et autres

Despite their inability to reproduce naturally, mules can host embryos and be surrogate dams. The aim of this investigation was to increase our knowledge of the qualitative composition of mule’s milk and its variations throughout the whole lactation period—namely, from 6 h …

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Host genetics and COVID-19 severity: increasing the accuracy of latest severity scores by Boolean quantum features

Gabriele Martelloni, Alessio Turchi, Chiara Fallerini, Andrea Degl’Innocenti et autres

The impact of common and rare variants in COVID-19 host genetics has been widely studied. In particular, in Fallerini et al. (Human genetics, 2022, 141, 147–173), common and rare variants were used to define an interpretable machine learning model for predicting COVID-19 …

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How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Craig R. G. Willis, Marco Calvaruso, Debora Angeloni, Sarah Baatout et autres

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, "Biology in Space and Analogue Environments", focusses in 5 main topic areas, aiming to address key community-identified knowledge …

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How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Trent Davis, Kevin Tabury, Shouan Zhu, Debora Angeloni et autres

Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment …

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Kdm7a expression is spatiotemporally regulated in developing Xenopus laevis embryos, and its overexpression influences late retinal development

Davide Martini, Matteo Digregorio, Ilaria Anna Pia Voto, Giuseppe Morabito et autres

BACKGROUND: Post-translational histone modifications are among the most common epigenetic modifications that orchestrate gene expression, playing a pivotal role during embryonic development and in various pathological conditions. Among histone lysine demethylases, KDM7A, also known as KIAA1718 or JHDM1D, catalyzes the demethylation of …

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How do gravity alterations affect animal and human systems at a cellular/tissue level?

Francesca Cialdai, Austin McNeill Brown, Cory W. Baumann, Debora Angeloni et autres

The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that prevent us from answering the question: "How Do Gravity Alterations Affect Animal and Human Systems at a Cellular/Tissue …

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Ultra-rare RTEL1 gene variants associate with acute severity of COVID-19 and evolution to pulmonary fibrosis as a specific long COVID disorder

Laura Bergantini, Margherita Baldassarri, Miriana d’Alessandro, Giulia Brunelli et autres

BACKGROUND: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel coronavirus that caused an ongoing pandemic of a pathology termed Coronavirus Disease 19 (COVID-19). Several studies reported that both COVID-19 and RTEL1 variants are associated with shorter telomere length, but a …

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Host genetics and COVID-19 severity: increasing the accuracy of latest severity scores by Boolean quantum features

Gabriele Martelloni, Alessio Turchi, Chiara Fallerini, Andrea Degl’Innocenti et autres

ABSTRACT The impact of common and rare variants in COVID-19 host genetics is widely studied in [16]. Here, common and rare variants were used to define an interpretable machine learning model for predicting COVID-19 severity. Firstly, variants were converted into sets of …

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