Li Zhu

Author Correction: Lysosomal “TRAP”: a neotype modality for clearance of viruses and variants

Chengliang Lyu, Zhanlong He, Xiaoming Hu, Shuang Wang et autres

In the original version of this Article, several data-handling errors occurred during preparation of the Source data underlying the Supplementary Figs. S3g, S5c, S5e, and S21c.

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Bardoxolone methyl exerts an inhibitory effect on respiratory syncytial virus infection by downregulating IL-6 via the IKKβ/NF-κB signaling pathway

Xunping Wu, Hongping Wang, Ling Zhang, Bingyao Wang et autres

ABSTRACT Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections in infants, older adults, and immunocompromised individuals, but therapeutic options for active infection remain limited. Interleukin-6 (IL-6) contributes to RSV replication and RSV-induced inflammation, and the IKKβ/NF-κB pathway is a major …

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Modular Development of a Klebsiella pneumoniae Bioconjugate Nanovaccine Elicits Robust Protection via Intranasal Immunization

Zhenshi Li, Lingli Chen, Can Liu, Kangfeng Wang et autres

Klebsiella pneumoniae poses a severe global health threat due to its extensive antibiotic resistance. However, to date, no vaccine against this pathogen has been approved for clinical use worldwide. Although self-assembling nanocarriers present distinct advantages for vaccine design, their ability to effectively …

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Synergistic sieving-thermodynamic adsorption purification of perfluoropropane over Ag+-loaded carbon molecular sieve

Zhenglin Du, Zhikang Wu, Xinxin Li, Weiwei Zhang et autres

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Development of a Promising Ferritin-Based Bioconjugate Nanovaccine Candidate against Brucellosis

Wenjun Li, Juntao Li, Xiao-lin Cao, Na Song et autres

Brucellosis, a global zoonosis caused by Brucella species, currently lacks safe vaccines for human use, while existing veterinary live-attenuated vaccines pose infection risks. Although ferritin nanoparticle materials have shown significant advantages in delivery, there is not much research on loading complex polysaccharide …

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Multiplexed Aptamer-Lattice Nanodevice for One-Step Phenotyping and Functional Quality Control of CAR-T Cells

Meixia Wang, Li Zhu, Yangbing Li, Yangguang Zhao et autres

Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized cancer treatment but continues to face substantial quality control challenges due to cellular heterogeneity. Here, we report a multiplexed nanodevice, the Aptamer Lattice-Powered Hybrid Architecture (ALPHA), for one-step phenotypic and functional analysis of …

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Modular assembly and immunological evaluation of a promising bioconjugate nanovaccine against Klebsiella pneumoniae O2 serotype

Peng Sun, Chao Pan, Huifang Xu, Бо Лю et autres

The antimicrobial-resistant (AMR) Klebsiella pneumoniae (Kp) poses an enormous threat to human health, with O2 serotypes accounting for up to 35-59% of infections. Although the O-polysaccharide (OPS) of the Kp O2 serotype can be used as an antigen target for vaccine preparation, …

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Biosynthesis of Two Types of Exogenous Antigenic Polysaccharides in a Single Escherichia coli Chassis Cell

Jingjing Hao, H H Liao, Shuhong Meng, Yan Guo et autres

Escherichia coli and Klebsiella pneumoniae are major contributors to the global challenge of antimicrobial resistance, posing serious threats to public health. Among current preventive strategies, conjugate vaccines that utilize bacterial surface polysaccharides have emerged as a promising and effective approach to counter …

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A Bioconjugate Vaccine Against Extra-Intestinal Pathogenic Escherichia coli (ExPEC)

Linhui Hao, Wenhua Huang, Yan Guo, Xiankai Liu et autres

Background: Extra-intestinal pathogenic Escherichia coli (ExPEC) represents a major global public health challenge due to its ability to cause diverse clinical infections, including urinary tract infections, bacteremia, neonatal meningitis, and sepsis. The growing prevalence of multidrug-resistant (MDR) ExPEC strains, which rapidly erode …

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Novel cell factory for the production of 24-epi-ergosterol, an un-natural semi-synthetic precursor for the production of brassinolide in Yarrowia lipolytica

Yuanying Wang, S.-W. Liu, Yun Feng, Yinmiao Wang et autres

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EPAS1 Variations and Hematological Adaptations to High-Altitude Hypoxia in Indigenous Goats in Yunnan Province, China

Li Zhu, Lin Tang, Shanshan Li, Xiao Gou et autres

The EPAS1 gene plays a central role in hypoxia adaptation in high-altitude animals. Using over 400 blood samples from goats across elevations in Yunnan (500–3500 m), this study examined hematological traits, genetic polymorphisms, and protein structure. Red blood cell (RBC) and hemoglobin …

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Comprehensive Evaluation of Γ-Glutamyl Peptide's Multi-Functional Effects on Skin Hydration, Barrier and Repair Function

Xu Zhao, Chun Cui, Li Zhu, Na Li

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