Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH
Michiko Itoh, Atsushi Tamura, S KANAI, Miyako Tanaka et autres
Accumulation of lipotoxic lipids, such as free cholesterol, induces hepatocyte death and subsequent inflammation and fibrosis in the pathogenesis of nonalcoholic steatohepatitis (NASH). However, the underlying mechanisms remain unclear. We have previously reported that hepatocyte death locally induces phenotypic changes in the …
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