Loïc Vasseur

Assessing time-dependent discrimination of prognostic model with intercurrent treatment: use of multi-state modelling for inverse probability censoring weighting

Loïc Vasseur, Derek Hazard, Nicolas Boissel, Martin Wolkewitz et autres

Prognostic markers may be used to inform clinical decision about treatment. As a consequence, it is difficult to disentangle the prognostic value of the marker from the treatment effect especially when treatment is started after baseline. Following the estimand framework, a solution …

Transplant versus no transplant outcome in adolescents and adults with sickle cell disease eligible for allogeneic hematopoietic stem cell transplantation

Cécile Pivert, Loïc Vasseur, Matthieu Jestin, E Flamarion et autres

Hematopoietic stem cell transplantation (HSCT) remains the only curative option for sickle cell disease (SCD), but its use in adolescents and adults is limited by toxicity concerns. We evaluated the risk-benefit profile of HSCT in this population through a comparative analysis of …

fr, us, gp, ch, mq, ca (code pays fourni par la source)

Genomic landscape of acute myeloid leukemia in adolescents and young adults

Loïc Vasseur, Nicolas Duployez, Jérôme Lambert, Hélène Lapillonne et autres

fr, us (code pays fourni par la source)

Prognostic impact of intensive chemotherapy in patients with TP53-mutated AML

Laurène Fenwarth, Loïc Vasseur, Nicolas Duployez, Augustin Boudry et autres

The authors would like to thank all the investigators and clinical research associates from the ALFA-0701, ALFA-0702, and ALFA-1200 protocols. The authors thank Christophe Roumier for handling, conditioning, and storing patient samples (Tumour Bank for the Acute Leukemia French Association certification NF …

fr, us (code pays fourni par la source)

CEBP and ZEB2 alterations define three distinct subtypes of B‐cell acute lymphoblastic leukemia

Rathana Kim, Marie Passet, Hugo Bergugnat, Loïc Vasseur et autres

Abstract B‐cell acute lymphoblastic leukemia (B‐ALL) is a heterogeneous malignancy driven by diverse genetic alterations. Among these, CEBP family genes and ZEB2 are recurrently involved, yet the spectrum of genomic mechanisms and their clinical impact remain incompletely defined. Integrated genomic analyses of …

fr, be, ch, us (code pays fourni par la source)

Alternative versus matched unrelated donor in adolescents and young adults transplanted for acute myeloid leukemia in first complete remission: A report from the SFGM-TC

Aude-Marie Fourmont, David Beauvais, M Balsat, Johan Maertens et autres

ca, fr, be, us (code pays fourni par la source)

Genetic alterations and measurable residual disease in core binding factor acute myeloid leukemia

Loïc Vasseur, Matthieu Duchmann, Nicolas Duployez, E. Raffoux et autres

fr, us, ca (code pays fourni par la source)

Challenges in handling allogeneic stem cell transplantation in randomized clinical trials

Roxane Couturier, Loïc Vasseur, Nicolas Boissel, Hervé Dombret et autres

BACKGROUND: In randomized clinical trials (RCTs) for hematological malignancies, patients may undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT) as part of standard clinical pathways. Allo-HSCT is a potentially curative but high-risk procedure performed after randomization and thus constitutes an important intercurrent event …

fr, us (code pays fourni par la source)

Impact of right-censoring of post-randomization allogeneic stem cell transplantation on hypothetical estimand of the treatment effect in acute leukemia trials

Roxane Couturier, Loïc Vasseur, Jérôme Lambert, Sylvie Chevret

fr (code pays fourni par la source)

Integrating palliative care for adolescents and young adults with hematologic malignancies: Insights from a dedicated french unit.

Agathe Picard, Victoria Hadida, Matthieu Jestin, Candice Cavalie et autres

Abstract Context. The outcome of adolescents and young adults (AYA) aged 15 to 25 with cancer has improved, with five-year survival rates now exceeding 85%. However, disease progression remains the leading cause of death in this population. AYAs face unique challenges that …

fr, us (code pays fourni par la source)

Therapy-related core binding factor Acute Myeloid Leukemia – a Study of the french acute leukemia intergroup

Mathilde Chanut, Loïc Vasseur, Matthieu Duchmann, Pierre Hirsch et autres

Abstract Introduction Therapy-related CBF-AMLs represent approximately 10% of all CBF-AMLs and are associated with poorer outcomes, partly due to the associated solid tumor. Existing studies are small, and more data—especially NGS and cytogenetics—are needed to better define their characteristics and prognosis. Methods …

fr, ca (code pays fourni par la source)

Blinatumomab dans la leucémie aiguë lymphoblastique B sans chromosome de Philadelphie en rémission complète avec persistance d’une maladie résiduelle positive

Mathilde Chanut, Loïc Vasseur

fr (code pays fourni par la source)