Jaap J. Schuurmans

The authors reply:

Jaap J. Schuurmans, Santino R. Rellum, Denise Petra Veelo, Alexander P. J. Vlaar et autres

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The hypotension prediction index versus mean arterial pressure in predicting intraoperative hypotension

Santino R. Rellum, Sijm H. Noteboom, Björn J. P. van der Ster, Jaap J. Schuurmans et autres

BACKGROUND: The hypotension prediction index (HPI) predicts hypotension, with randomised trials showing a significant reduction in hypotension-related metrics. However, the reliability of previous validation studies is debated, and it's unclear if mean arterial pressure (MAP) can be used interchangeably with HPI. OBJECTIVES: …

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Gut microbial dysbiosis, IgA, and Enterococcus in common variable immunodeficiency with immune dysregulation

Roos-Marijn Berbers, Fernanda L. Paganelli, Joris M. van Montfrans, Pauline M. Ellerbroek et autres

BACKGROUND: Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia and recurrent infections. Significant morbidity and mortality are caused by immune dysregulation complications (CVIDid), which affect around one-third of CVID patients and have a poorly understood etiology. Here, we investigate the hypothesis that …

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Effect of a Machine Learning-Derived Early Warning Tool With Treatment Protocol on Hypotension During Cardiac Surgery and ICU Stay: The Hypotension Prediction 2 (HYPE-2) Randomized Clinical Trial

Jaap J. Schuurmans, Santino R. Rellum, Jimmy Schenk, Björn J. P. van der Ster et autres

OBJECTIVES: Cardiac surgery is associated with perioperative complications, some of which might be attributable to hypotension. The Hypotension Prediction Index (HPI), a machine-learning-derived early warning tool for hypotension, has only been evaluated in noncardiac surgery. We investigated whether using HPI with diagnostic …

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Pulmonary herpes simplex virus and cytomegalovirus in patients with acute respiratory distress syndrome related to COVID-19

Leonoor S. Boers, Frank van Someren Gréve, Jarne M. van Hattem, Justin de Brabander et autres

PURPOSE: Human herpesviruses, particularly cytomegalovirus (CMV) and herpes simplex virus (HSV), frequently reactivate in critically ill patients, including those with acute respiratory distress syndrome (ARDS) related to coronavirus disease 2019 (COVID-19). The clinical interpretation of pulmonary herpesvirus reactivation is challenging and there …

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Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

Astrid Marchal, Elizabeth T. Cirulli, Iva Neveux, Evangelos Bellos et autres

Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of …

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The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients

M. Slim, Endry H. T. Lim, Lonneke A. van Vught, A. M. Tuip-de Boer et autres

While several effective therapies for critically ill patients with COVID-19 have been identified in large, well-conducted trials, the mechanisms underlying these therapies have not been investigated in depth. Our aim is to investigate the association between various immunosuppressive therapies (corticosteroids, tocilizumab and …

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Validation and clinical applicability of the Hypotension Prediction Index in a general ICU population: a prospective observational cohort study Study acronym Prediction of Hemodynamic Instability in Patients Admitted to the ICU; the PHYSIC study

Lotte E. Terwindt, Denise Petra Veelo, Max Ligtenberg, Jaap J. Schuurmans et autres

Abstract Background: Hypotension is associated with adverse outcomes in patients admitted to the intensive care unit (ICU). The application of an arterial blood pressure derived algorithm predicting hypotension significantly reduced hypotension during surgery. This Hypotension Prediction Index (HPI), calculates the likelihood (range …

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Biomarker Analysis Provides Evidence for Host Response Homogeneity in Patients With COVID-19

Rombout B. E. van Amstel, Erik H.A. Michels, Brent Appelman, Justin de Brabander et autres

Background The exploration of subphenotypes in hospitalized patients with COVID-19 has garnered substantial attention. Most existing studies operate under the assumption of heterogeneity in COVID-19 patient populations, and this assumption can lead to erroneous conclusions. Research Question Do plasma biomarker profiles reflective …

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Heterogeneity in a meta-analysis: randomized controlled trials versus observational studies. Author’s reply

Jaap J. Schuurmans, Denise Petra Veelo, Alexander P. J. Vlaar, Jimmy Schenk

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Hypotension during intensive care stay and mortality and morbidity: a systematic review and meta-analysis

Jaap J. Schuurmans, Benthe T. B. van Rossem, Santino R. Rellum, Johan T. M. Tol et autres

PURPOSE: The aim of this study is to provide a summary of the existing literature on the association between hypotension during intensive care unit (ICU) stay and mortality and morbidity, and to assess whether there is an exposure-severity relationship between hypotension exposure …

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Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang et autres

International audience

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