Rebecca E. Steele

Abstract 56: COSMIC: Advancing the cancer genomics knowledgebase of somatic mutations.

Madhumita Madhumita, Madiha Ahmed, Joanna Argasinska, D. J. Armstrong et autres

Abstract COSMIC (Catalogue Of Somatic Mutations in Cancer) has evolved from an initial catalogue to the world's most comprehensive knowledgebase of somatic variants in cancer, built upon a foundation of continuous, expert curation. COSMIC currently aggregates over 29 million unique somatic variants …

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Abstract B007: Unravel the role of extracellular NNMT (eNNMT) in the modulation of prostate cancer (PC) tumour immune microenvironment (TIME)

Agata Carreira, Marianna Ciuffreda, Nathakan Thongon, Elena Cerri et autres

Abstract Cellular plasticity enables cancer cells to acquire new biological properties and become resistant to therapy. Late-stage castration resistant prostate cancer (CRPC) present heterogenous phenotypes in response to antiandrogen therapy, which likely arise from widely plastic adenocarcinomas, but invariably renders hormonal therapy …

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Nicotinamide N-Methyl Transferase (NNMT) Sustains Innate Sensitivity to NAMPT Inhibition in YAP-dependent Stem-like/Mesenchymal Prostate Cancer

Ágata Sofia Assunção Carreira, Marianna Ciuffreda, Nathakan Thongon, Charles M. Haughey et autres

Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD + salvage pathway and a promising therapeutic target in cancer.Resistance to NAMPT inhibitors, such as FK866, remains a key limitation to their clinical translation.While acquired resistance in cancer cell lines has been …

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77eP Decoding glioblastoma through integrated analysis using the COSMIC knowledge base

L. Chadelle, Mike Starkey, Rebecca E. Steele, M. Madhumita et autres

NNMT drives innate sensitivity to NAMPT inhibition in YAP-dependent stem-like/ mesenchymal prostate cancer

Ágata Sofia Assunção Carreira, Marianna Ciuffreda, Natthakan Thongon, Charles M. Haughey et autres

ABSTRACT Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD+ salvage pathway and a promising therapeutic target in cancer. Resistance to NAMPT inhibitors, such as FK866, remains a key limitation to their clinical translation. While acquired resistance in cancer cell lines …

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Experiences and preferences about information on treatment-related side effects among patients with early breast cancer

Antonio Di Meglio, Giuseppe Catanuto, Marzia Zambon, Alexandre Chan et autres

BACKGROUND: Treatment-related side effects are common among women treated for early breast cancer and their effective management is essential to maintain quality of life, ensure treatment adherence, and optimise survival outcomes. This study aimed to investigate patient-reported experiences and preferences about information …

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Effectiveness Of A Virtual Guideline Directed Medical Therapy Titration Program In Improving Outcomes For Heart Failure Patients: A Study Of Ventricle Health's Digital Platform

Daniel Bensimhon, Eshwar Inapuri, Rebecca E. Steele, Kelly R. Peck et autres

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Abstract 3555: COSMIC: two decades of curating somatic variants in cancer

Zbysław Sońdka, Madiha Ahmed, Joanna Argasinska, David M. Beare et autres

Abstract In 2004, COSMIC was one of the first initiatives to integrate global data on somatic mutations in cancer. At the time it was explicit that the fragmentation of genetic datasets was a major obstacle to understand the processes driving cancer. A …

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Supplementary Data, Supplementary Figures and Legends 1-13 from Inhibition of O-GlcNAc Transferase Renders Prostate Cancer Cells Dependent on CDK9

Harri M. Itkonen, Ninu Poulose, Rebecca E. Steele, Sara E. S. Martin et autres

Supplementary figure 1. Validation of synthetic lethal interaction between OGT inhibition and AT7519 in LNCaP cells. Supplementary figure 2. Validation of synthetic lethal interaction between OSMI-2 and AT7519 in additional cell lines. Supplementary figure 3. Combination of OSMI-2 with AT7519 induces cells …

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Supplementary Data, Supplementary Figures and Legends 1-13 from Inhibition of O-GlcNAc Transferase Renders Prostate Cancer Cells Dependent on CDK9

Harri M. Itkonen, Ninu Poulose, Rebecca E. Steele, Sara E. S. Martin et autres

Supplementary figure 1. Validation of synthetic lethal interaction between OGT inhibition and AT7519 in LNCaP cells. Supplementary figure 2. Validation of synthetic lethal interaction between OSMI-2 and AT7519 in additional cell lines. Supplementary figure 3. Combination of OSMI-2 with AT7519 induces cells …

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Data from Inhibition of O-GlcNAc Transferase Renders Prostate Cancer Cells Dependent on CDK9

Harri M. Itkonen, Ninu Poulose, Rebecca E. Steele, Sara E. S. Martin et autres

Abstract O-GlcNAc transferase (OGT) is a nutrient-sensitive glycosyltransferase that is overexpressed in prostate cancer, the most common cancer in males. We recently developed a specific and potent inhibitor targeting this enzyme, and here, we report a synthetic lethality screen using this compound. …

Data from Inhibition of O-GlcNAc Transferase Renders Prostate Cancer Cells Dependent on CDK9

Harri M. Itkonen, Ninu Poulose, Rebecca E. Steele, Sara E. S. Martin et autres

Abstract O-GlcNAc transferase (OGT) is a nutrient-sensitive glycosyltransferase that is overexpressed in prostate cancer, the most common cancer in males. We recently developed a specific and potent inhibitor targeting this enzyme, and here, we report a synthetic lethality screen using this compound. …