Cindy Marquet

Efficacy of BAFF inhibition and B-cell depletion in non-obese diabetic mice as a spontaneous model for Sjögren’s disease

Renaud Felten, Anne‐Perrine Foray, Pascal Schneider, Cindy Marquet et autres

Introduction The therapeutic interest of targeting B-cell activating factor (BAFF) in Sjögren’s disease (SjD) can be suspected from the results of two phase II clinical trials but has not been evaluated in an animal model of the disease. We aimed to evaluate …

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Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice

Lucienne Chatenoud, Cindy Marquet, Fabrice Valette, Lindsay Scott et autres

Genetic association studies of type 1 diabetes (T1D) in humans, and in congenic non-obese diabetic (NOD) mice harboring DNA segments from T1D-resistant mice, face the challenge of assigning causation to specific gene variants among many within loci that affect disease risk. Here, …

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De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes

Anne‐Perrine Foray, Sophie Candon, Sara Hildebrand, Cindy Marquet et autres

Significance The vast majority of autoimmune diseases are polygenic, and causal loci uncovered by genetic-mapping studies explain only a minority of the heritable contribution to trait variation. Multiple explanations for this missing heritability include rare meaningful variants, rare copy number variations or …

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De novo germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice

Anne‐Perrine Foray, Sophie Candon, Sara Hildebrand, Cindy Marquet et autres

Abstract Here we report the isolation by selective breeding of two sublines of Non-Obese Diabetic (NOD) mice exhibiting a significant difference in the incidence of autoimmune type 1 diabetes (T1D). Whole genome sequencing of the NOD/Nck H (high T1D incidence) and NOD/Nck …

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Regulatory mechanisms of immune tolerance in type 1 diabetes and their failures

Chantal Kuhn, Alix Besançon, Sébastien Lemoine, Sylvaine You et autres

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Correction: Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes

Sophie Candon, Alicia Pérez, Cindy Marquet, Fabrice Valette et autres

Control of Immune Response to Allogeneic Embryonic Stem Cells by CD3 Antibody–Mediated Operational Tolerance Induction

Damelys Calderon, Matthieu Prot, Sylvaine You, Cindy Marquet et autres

Implantation of embryonic stem cells (ESCs) and their differentiated derivatives into allogeneic hosts triggers an immune response that represents a hurdle to clinical application. We established in autoimmunity and in transplantation that CD3 antibody therapy induces a state of immune tolerance. Promising …

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Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes

Sophie Candon, Alicia Pérez, Cindy Marquet, Fabrice Valette et autres

Insulin-dependent or type 1 diabetes is a prototypic autoimmune disease whose incidence steadily increased over the past decades in industrialized countries. Recent evidence suggests the importance of the gut microbiota to explain this trend. Here, non-obese diabetic (NOD) mice that spontaneously develop …

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