Janne K. Nieminen

Comprehensive antigen profiling predicts post-surgical neuropathic pain in women treated for breast cancer

Helle Sadam, Laura Mustonen, Annika Rähni, Janne K. Nieminen et autres

The importance of neuroimmune interactions in neuropathic pain (NP) has been established, but antibody-mediated mechanisms remain underexplored. In this explorative case-control study, we analyzed antibody profiles in patients with intercostobrachial nerve injury during breast cancer (BC) surgery. We compared 27 patients who …

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HLA ‐Region Genetic Association Analysis of Breast Cancer Patients With and Without Persistent Postsurgical Neuropathic Pain

Laura Mustonen, Janne K. Nieminen, Satu Koskela, Mari Anneli Kaunisto et autres

BACKGROUND: Surgical nerve injuries lead to persistent neuropathic pain (NP) in up to 30% of patients. Among many other factors, polymorphisms in the human leukocyte antigen (HLA) genes have been suggested to contribute to the development of neuropathic pain. METHODS: We performed …

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Epstein-Barr Virus in the Cerebrospinal Fluid and Blood Compartments of Patients With Multiple Sclerosis and Controls

Joonas Lehikoinen, Katariina Nurmi, Mari Ainola, Jonna Clancy et autres

BACKGROUND AND OBJECTIVES: Epstein-Barr virus (EBV) infection is a major risk factor of multiple sclerosis (MS). We examined the presence of EBV DNA in the CSF and blood of patients with MS and controls. We analyzed whether EBV DNA is more common …

Cultured lymphocytes’ mitochondrial genome integrity is not altered by cladribine

Elina Järvinen, Fumi Suomi, James Bruce Stewart, Dimitri Guala et autres

Cladribine tablets are a treatment for multiple sclerosis with effects on lymphocytes, yet its mode of action has not been fully established. Here, we analyzed the effects of cladribine on mitochondrial DNA integrity in lymphocytes. We treated cultured human T-cell lines (CCRF-CEM …

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Lymphocyte mitochondrial genome integrity is not altered by cladribine

Elina Järvinen, Fumi Suomi, James Bruce Stewart, Dimitri Guala et autres

Abstract Cladribine tablets are a treatment for multiple sclerosis (MS) with effects on lymphocytes’, yet its mode of action has not been fully established. Here, we evaluated the effects of cladribine on mitochondrial DNA integrity in human lymphocytes. We treated cultured human …

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Immune response to a conserved enteroviral epitope of the major capsid VP1 protein is associated with lower risk of cardiovascular disease

Nadežda Pupina, Annela Avarlaid, Helle Sadam, Arno Pihlak et autres

BACKGROUND: Major cardiac events including myocardial infarction (MI) are associated with viral infections. However, how specific infections contribute to the cardiovascular insults has remained largely unclear. METHODS: We employed next generation phage display mimotope-variation analysis (MVA) to explore the link between antibody-based …

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Distribution of perfluoroalkyl acids in fish species from the Baltic Sea and freshwaters in Finland

Eva Kumar, Jani M. Koponen, Panu Rantakokko, Riikka Airaksinen et autres

Occurrence and distribution of perfluoroalkyl acids (PFAAs), a sub-category of per- and polyfluoroalkyl substances (PFASs), is widespread in the environment. Food, especially fish meat, is a major pathway via which humans are exposed to PFAAs. As fish is an integral part of …

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Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life

Terhi Ruohtula, Anita Kondrashova, Jussi P. Lehtonen, Sami Oikarinen et autres

Early childhood infections have been implicated in the development of immune-mediated diseases, such as allergies, asthma, and type 1 diabetes. We set out to investigate the immunomodulatory effects of early viral infections experienced before the age of one year on the peripheral …

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Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients

Helle Sadam, Arno Pihlak, Mariliis Jaago, Nadežda Pupina et autres

BACKGROUND: Optic neuritis (ON) can occur as an isolated episode or will develop to multiple sclerosis (MS) a chronic autoimmune disease. What predicts ON progression to MS remains poorly understood. METHODS: We characterised the antibody epitope repertoire in three independent clinical cohorts …

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Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life

Terhi Ruohtula, Marcus C. de Goffau, Janne K. Nieminen, Jarno K. Honkanen et autres

Recent studies suggest that the cross talk between the gut microbiota and human immune system during the first year of life is an important regulator of the later development of atopic diseases. We explored the dynamic changes in the gut microbiota and …

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Rhinoviruses in infancy and risk of immunoglobulin E sensitization

Laura Korhonen, Sami Oikarinen, Jussi P. Lehtonen, Neea Mustonen et autres

Early childhood infections and the use of antibiotics and antipyretic-analgesics in Finland, Estonia and Russian Karelia

Neea Mustonenh, Heli Siljander, Aleksandr Peet, Vallo Tillmann et autres