Feng‐Jie Shen

Microplastics impair wound healing via NAT10-mediated epigenetic dysregulation of FASN-PI3K/AKT signaling

Feng‐Jie Shen, Wanwen Cao, Yuan Wang, Rong Zhang et autres

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Low-dose polystyrene microplastics exposure increases susceptibility to obesity-induced MASLD via disrupting intestinal barrier integrity and gut microbiota homeostasis

Gang Wei, Kai Zhang, Feng‐Jie Shen, Rongrong Xie et autres

The global incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) has surged in recent years, potentially impacted by both high-energy food intake (e.g., high-fat diet, HFD) and environmental pollutants like microplastics (MPs). However, the combined impacts of MPs exposure and HFD feeding, …

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Polystyrene microplastics exposure increases the disruption of intestinal barrier integrity and gut microbiota homeostasis during obesity and aging

Gang Wei, Wangrui Liu, Feng‐Jie Shen, Rongrong Xie et autres

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Resinacein S, a novel triterpenoid from functional mushroom Ganoderma resinaceum , curbs obesity by regulating thermogenesis and energy metabolism

Gang Wei, Feng‐Jie Shen, Jun‐Li Liu, Jianhua Zhao et autres

Ganoderma mushrooms are popularly used as dietary supplements to promote health around the world. However, their potential applications for the prevention and treatment of obesity needs to be further investigated. In this study, we isolated a novel triterpenoid from Ganoderma resinaceum, Resinacein …

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Uncoupling protein 1 deficiency leads to transcriptomic differences in livers of pregnancy female mice and aggravates hepatic steatosis

Gang Wei, Feng‐Jie Shen, Junli Liu, Jianhua Zhao et autres

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Causal relationship of familial hypercholesterolemia with risk of intestinal vascular disorders: A mendelian randomization study

Gang Wei, Cheng Zhang, Feng‐Jie Shen, Lin Liu

The causal relationship between the familial hypercholesterolemia (FH) and intestinal vascular diseases was unnoticed. This study aims to investigate the cause-and-effect relationship of FH with risk of intestinal vascular diseases in human. A Mendelian randomization (MR) analysis was performed by extracting summary-level …

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Heterogeneous metabolic changes of brown and white adipose tissues are associated with metabolic adaptations in periparturient mice

Gang Wei, Juanjuan Zhu, Feng‐Jie Shen, Rongrong Xie et autres

Pregnancy requires metabolic adaptations in order to meet support fetal growth with nutrient availability. In this study, the influence of pregnancy on metabolically active organs (adipose tissues in particular) was investigated. Our results showed that maternal weight and adipose mass presented dynamic …

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Hsa_circ_0008500 inhibits apoptosis of adipose‐derived stem cells under high glucose through hsa‐miR ‐1273h‐5p/ ELK1 axis

Fandong Meng, Feng‐Jie Shen, xuan chu, Hongwei Ling et autres

Preliminary researches have confirmed that the number of apoptosis of adipose tissue-derived stem cells (ADSCs) in patients with diabetes is significantly increased, leading to a difficult healing wound. Increasing researches revealed that circular RNAs (circRNAs) can control apoptosis. However, it is still …

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Diagnostic value of triglyceride and cystatin C ratio in diabetic kidney disease: a retrospective and prospective cohort study based on renal biopsy

Jing Wei, Bo Wang, Feng‐Jie Shen, Tingting Zhang et autres

BACKGROUND: Currently, there is a lack of clinical indicators that can accurately distinguish diabetic kidney disease (DKD) from non-diabetic kidney disease (NDKD) in type 2 diabetes. The purpose of this study was to investigate the diagnostic value of triglyceride and cystatin C …

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Diagnostic value of triglyceride and cystatin C ratio in diabetic nephropathy: a retrospective and prospective cohort study based on renal biopsy

Jing Wei, Bo Wang, Feng‐Jie Shen, Tingting Zhang et autres

Abstract Background: To investigate the diagnostic value of triglyceride and cystatin C (TG/Cys-C) ratio in diabetic nephropathy (DKD). Methods: The clinical data of patients with type 2 diabetes complicated with proteinuria who underwent renal biopsy from January 2013 to September 2019 in …

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Effect of Riluzole on the Expression of HCN2 in Dorsal Root Ganglion Neurons of Diabetic Neuropathic Pain Rats

Dongmei Zhou, Feng‐Jie Shen, Hao Rong, Bei-Miao et autres

Neuropathic pain since early diabetes swamps patients' lives, and diabetes mellitus has become an increasingly worldwide epidemic. No agent, so far, can terminate the ongoing diabetes. Therefore, strategies that delay the process and the further complications are preferred, such as diabetic neuropathic …

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Establishment and Validation of a Nomogram Model for Prediction of Diabetic Nephropathy in Type 2 Diabetic Patients with Proteinuria

Dongmei Zhou, Jing Wei, Tingting Zhang, Feng‐Jie Shen et autres

Purpose: To establish and validate the nomogram model for predicting diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM) patients with proteinuria. Methods: A total of 102 patients with T2DM and proteinuria who underwent renal biopsy were included in this study. According …

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