Cristina Cusin

The extent and durability of improvement in depressive symptoms, quality of life, and daily function with three years of vagus nerve stimulation in markedly treatment-resistant depression: A RECOVER study report

Charles R. Conway, Scott T. Aaronson, A. John Rush, Ying-Chieh Lee et autres

Abstract Background Management of markedly treatment-resistant depression is characterized by low initial benefit and poor durability. Treatments with sustained benefits are needed. This report summarizes clinical outcomes and durability of both the active treatment arm (Early-Active) and the initially sham treatment arm …

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Mindfulness mediates depressive symptom improvement during heated yoga: a secondary analysis of a randomized controlled trial

Daniel Copeland, Naoise Mac Giollabhui, Louisa Sylvia, Doga Cetinkaya et autres

Abstract Background Despite growing evidence that lifestyle interventions reduce depressive symptoms, the psychological mechanisms underlying these effects remain poorly understood. This study examined whether mindfulness and rumination mediate the antidepressant effects of heated yoga (HY), a multicomponent intervention combining physical activity, attentional …

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Oral Ketamine for Treatment-Resistant Depression—Not Yet Time?

Cristina Cusin

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Changes in depression symptom network structure following ketamine treatment in treatment-resistant depression

Joshua Curtiss, Laya Dasari, Julianne Origlio, Catherine Schuessler et autres

Major Depressive Disorder (MDD) affects millions globally, with approximately 30% of patients experiencing treatment-resistant depression (TRD). While ketamine has emerged as a rapid-acting intervention, response rates remain variable, underscoring the need to refine precision medicine approaches for ketamine treatment. Network theories of …

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121. Ketamine Modulates Auditory Habituation in Recurrent Depression: An EEG Study

Amir Meghdadi, Chris Berka, Ella Thunen, Eliana Prosnitz et autres

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Pallidal alpha activity is an electrophysiological biomarker of symptom severity in obsessive-compulsive disorder

Matteo Vissani, Ali Reza Tafreshi, Clemens Neudorfer, Pranav Nanda et autres

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The Use of Vagus Nerve Stimulation (VNS) in the Management of Patients with Difficult-to-Treat Major Depressive Disorder (MDD): An Expert Consensus Statement

R Hamish McAllister-Williams, Gustavo Alva, Michael D. Banov, Charles Conway et autres

Purpose: Substantial evidence supports the effectiveness of implanted Vagus Nerve Stimulation (VNS) in the management of unipolar difficult-to-treat depression (DTD). While the treatment is included in several national and international guidelines, there is limited information to guide clinicians regarding patient selection and …

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Comparative effectiveness and safety of esketamine versus injectable racemic ketamine and oral antidepressants for major depressive disorder: A population-based target trial emulation

Ching-Hua Julie Lee, Yunzhe Qian, Weiqun Yu, Cristina Cusin et autres

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Durability of the benefit of vagus nerve stimulation in markedly treatment-resistant major depression: a RECOVER trial report

Charles R Conway, Augustus John Rush, Scott T Aaronson, Mark T. Bunker et autres

IMPORTANCE: Greater levels of treatment resistance in major depressive disorder (MDD) are associated with lower rates of initial benefit and higher rates of relapse (lower durability). OBJECTIVE: Characterize depressive symptoms, function, and quality of life (QoL) over 24 months of adjunctive vagus …

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Durability of the Benefit of Vagus Nerve Stimulation in Markedly Treatment-Resistant Major Depression: A RECOVER Trial Report

Charles R. Conway, A. John Rush, Scott T. Aaronson, Mark T. Bunker et autres

ABSTRACT Importance Greater levels of treatment resistance in major depressive disorder (MDD) are associated with lower rates of initial benefit and higher rates of relapse (lower durability). Objective Characterize depressive symptoms, function, and quality of life (QoL) over 24 months of adjunctive …

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Clinical decision support for pharmacologic management of treatment-resistant depression with augmented large language models

Roy H. Perlis, Pilar F. Verhaak, Joseph F. Goldberg, Cristina Cusin et autres

Background: We evaluated whether a large language model could assist in selecting psychopharmacological treatments for adults with treatment-resistant depression. Methods: We generated 20 clinical vignettes reflecting treatment-resistant depression among adults based on distributions drawn from electronic health records. Each vignette was evaluated …

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Exploring Task Design and Heuristics Interaction Through a Knowledge‐Free Option Generation Task

Yanlin Chen, Yuen‐Siang Ang, Cristina Cusin, Maurizio Fava et autres

Past research on option generation, the mental process of creating possible courses of action for goal-directed behaviors, focused extensively on the outcomes of the process, specifically, the quantity and quality of options generated. Accordingly, various effects were introduced to describe and categorize …

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