Soroush Bijani

Promising Potential of Edaravone‐Loaded Nanogel in Ameliorating of Stroke in Rats: The Modulation of Immune Response

Leila Nasehi, Salar Jahangiri, Soroush Bijani, Mir‐Jamal Hosseini

OBJECTIVES: Ischemic stroke is mainly caused by the interruption of cerebral blood flow, which causes severe neurological damage and is one of the main drawbacks of death and disability worldwide. Edaravone (EDV) has been clinically used for the treatment of ischemic stroke …

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Application of edaravone-loaded nanogel in alleviating behavioral deficits and oxidative stress in schizophrenia rat model

Sina Montazeri, Soroush Bijani, Hamid Rashidzadeh, Ali Ramazani et autres

Schizophrenia is considered as a main one of the public health issues, and imposes numerous burdens on patients and society. We previously reported, the pathophysiology of schizophrenia is influenced by inflammation and mitochondrial dysfunction. Edaravone (EDV) as a potent antioxidant with neuroprotective …

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Neuroprotective effects of empagliflozin against scopolamine-induced memory impairment and oxidative stress in rats

Mahdieh Anoush, Neda Taghaddosi, Zahra Bokaii Hosseini, Fatemeh Rahmati-Najarkolaei et autres

Alzheimer's disease (AD) is one of the most common age-related neurodegenerative disorders. The main medicinal theory for the management of AD belongs to the acetyl-cholinesterase-inhibition pathway and NMDA antagonism. Recent investigation proposed memory improvement by sodium-glucose co-transporter 2 (SGLT2) inhibitors which indicated …

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Protective impact of Betanin against noise and scrotal hyperthermia on testicular toxicity in Wistar rat: Role of apoptosis, oxidative stress and inflammation

Soroush Bijani, Parvaneh Naserzadeh, Mir‐Jamal Hosseini

The heat exposure and white noise can induce damage on reproductive organs. The main objective of this study is to observe, if betanin administration could ameliorate oxidative stress, apoptosis and inflammation in testis of rodents following noise and scrotal hyperthermia exposure. Wistar …

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The role of gender differences in the outcome of juvenile social isolation: Emphasis on changes in behavioral, biochemical and expression of nitric oxide synthase genes alteration

Soroush Bijani, Fatemeh Sadat Kashfi, Sadaf Zahedi-Vanjani, Keivan Nedaei et autres

Social isolation can cause serious problem in performance of individuals in community. As gender differences may cause variation results in the severity of depressive behavior and response of patients to therapy, the impact of gender and the interaction of the level of …

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Protective effects of Betanin against noise and scrotal hyperthermia on testicular toxicity in wistar rats: Role of oxidative stress, apoptosis, and inflammation

Soroush Bijani, Mir‐Jamal Hosseini, Parvaneh Naserzadeh

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Edaravone Improved Behavioral Abnormalities, Alleviated Oxidative Stress Inflammation, and Metabolic Homeostasis Pathways in Depression

Sina Montazeri, Soroush Bijani, Mahdieh Anoush, Ali Sharafi et autres

Depression is one of the main factors affecting our daily performance. Among many putative compounds with effect on behavioral and pathophysiological alterations in depression, edaravone (EDV) demonstrates antioxidant and free radical scavenging properties. To investigate possible antidepressive and anxiolytic-like effects of EDV, …

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Edaravone Improves Streptozotocin-Induced Memory Impairment via Alleviation of Behavioral Dysfunction, Oxidative Stress, Inflammation, and Histopathological Parameters

Mahdieh Anoush, Soroush Bijani, Fatemeh Moslemifar, Fatemeh Jahanpour et autres

Alzheimer's disease (AD), as the main cause of dementia, has a progressive and neurodegenerative pattern with number of cases increasing over the next decades. Therefore, discovering an effective treatment with the ability to invert memory impairment and pathophysiological events of AD seems …

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P.064 Enhancing the neuroprotective properties of edaravone using glutathione nanogel as a promising carrier for brain drug delivery in transient global ischemia in a rodent model

Mir‐Jamal Hosseini, Soroush Bijani

Background: Edaravone (EDV) is an antioxidant that scavengs ROS, which is known to associate with pathophysiology of ischemic stroke. Low stability and bioavailability are major EDV drawbacks. Decorating nanogel surface with glutathione to target brain tissue was performed to optimize drug delivery. …

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Evaluation of the Smartphone Applications in Antibiotic Prescription

Ehsan Nabovati, Soroush Bijani, Behzad Bijani

Introduction: One of the important challenges for physicians is the choic e of the right antibiotics for various diseases. In this regard, a mobile application could be helpful. The main purpose of this study was to compare the quality of mobile applications …

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Enhancing the Neuroprotection Potential of Edaravone in Transient Global Ischemia Treatment with Glutathione- (GSH-) Conjugated Poly(methacrylic acid) Nanogel as a Promising Carrier for Targeted Brain Drug Delivery

Faezeh Mozafari, Hamid Rashidzadeh, Soroush Bijani, Faezeh Zare-Molaei et autres

Ischemic stroke is the most common among various stroke types and the second leading cause of death, worldwide. Edaravone (EDV) is one of the cardinal antioxidants that is capable of scavenging reactive oxygen species, especially hydroxyl molecules, and has been already used …

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Thymus daenensis extract prevents scopolamine‑induced memory impairment through declining oxidative stress in rats

Mahdieh Anoush, Nasrin Tayebi, Soroush Bijani, Mina Ebrahimi et autres

Memory and cognitive impairment induced by oxidative stress are among the main hallmarks of Alzheimer's disease's (AD) pathology. The present study aimed to investigate the potential neuroprotective effects of Thymus daenensis (T. daenensis) extract against scopolamine‑induced memory impairment and oxidative stress in …

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