Huali Wu

FDA Approval Summary: Erdafitinib for FGFR3 -Altered Locally Advanced or Metastatic Urothelial Carcinoma

William F. Maguire, Elaine Chang, Flora Mulkey, Vicky Hsu et autres

On January 19, 2024, the FDA granted traditional approval to erdafitinib for patients with locally advanced or metastatic urothelial carcinoma (la/mUC) with susceptible FGFR3 genetic alterations, as determined by an FDA-approved companion diagnostic test, whose disease has progressed on or after at …

us (code pays fourni par la source)

Inhibitory Effects of Nardostachys Jatamansi DC. Volatile Oil on Psychological Factors SP/CORT-Induced Hyperpigmentation

Man Yang, Kang Cheng, Jie Gu, Huali Wu et autres

cn (code pays fourni par la source)

Identifying high-risk drugs and demographic patterns in drug-induced liver injury from FAERS and CVARD analyses

Yun He, Shi‐Nan Wu, Penghe Wang, Shihang Tang et autres

Drug-induced liver injury (DILI) is a major cause of acute liver failure, yet identifying associated drugs has been limited by the lack of large-scale analyses. This study addresses this gap by analyzing adverse event reports from the FDA Adverse Event Reporting System …

cn (code pays fourni par la source)

US Food and Drug Administration Approval Summary: Ribociclib With an Aromatase Inhibitor in the Adjuvant Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Stage II and III High-Risk Early Breast Cancer Treatment Setting

Jennifer Gao, Tatiana M. Prowell, Haley Gittleman, Joyce Cheng et autres

PURPOSE On September 17, 2024, the US Food and Drug Administration (FDA) approved ribociclib in combination with an aromatase inhibitor (AI) for the adjuvant treatment of adults with hormone receptor–positive, human epidermal growth factor receptor 2 (HER2)–negative stage II and III early …

us (code pays fourni par la source)

Structural Insights into Ni–Fe Layered Double Hydroxides as Anode Catalysts for Pairing CO2 Reduction and Ethylene Glycol Oxidation

Jiefeng Liu, Yuwei Yang, Eddy Petit, Valérie Bonniol et autres

Harnessing renewable electricity for CO 2 electroreduction is essential for the low-carbon production of chemicals and fuels. Traditional methods combine the CO 2 reduction reaction (CO 2 RR) with the oxygen evolution reaction (OER), which has high energy consumption and low-value products. …

fr, au, us (code pays fourni par la source)

2D Vermiculite Nanolaminated Membranes for Efficient Organic Solvent Nanofiltration (Adv. Funct. Mater. 16/2025)

Wensen Wang, Xishun Hao, Youguo Yan, Rong Sun et autres

2D Vermiculite Nanolaminated Membranes In article number 2410635, Damien Voiry and co-workers present the development of 2D vermiculite nanolaminated membranes with enhanced stability and molecular sieving capabilities for organic solvent nanofiltration (OSN). Through Fe3+ intercalation, the membranes achieve high rejection rates (>95% …

fr, cn, es, hk (code pays fourni par la source)

Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus

Stephanie N. Langel, Claire E. Otero, Justin T. Steppe, Caitlin A. Williams et autres

Dimeric IgA (dIgA) is the dominant antibody in many mucosal tissues. It is actively transported onto mucosal surfaces as secretory IgA (sIgA) which plays an integral role in protection against enteric pathogens, particularly in young children. Therapeutic strategies that deliver engineered, potently …

us (code pays fourni par la source)

Research progress on interferon and cellular senescence

Da Wang, Kaixian Chen, Zheng Wang, Huali Wu et autres

Since the 12 major signs of aging were revealed in 2023, people's interpretation of aging will go further, which is of great significance for understanding the occurrence, development, and intervention in the aging process. As one of the 12 major signs of …

cn (code pays fourni par la source)

Grain-Boundary Engineering Boosted Undercoordinated Active Sites for Scalable Conversion of CO2 to Ethylene

Yang Zhang, Kun Qi, Pengbo Lyu, Eddy Petit et autres

The development of highly selective and energy efficient technologies for electrochemical CO 2 reduction combined with renewable energy sources holds great promise for advancing the field of sustainable chemistry. The engineering of copper-based electrodes facilitates the conversion of CO 2 into high-value …

fr, cn, kr (code pays fourni par la source)

Germacrone, isolated from Curcuma wenyujin, inhibits melanin synthesis through the regulation of the MAPK signaling pathway

Xiaoye Li, Lijia Chen, Hong Wang, Yi‐Ming Li et autres

cn (code pays fourni par la source)

Ursolic acid derivative UAOS-Na treats experimental autoimmune encephalomyelitis by immunoregulation and protecting myelin

Maolin Wang, Chenming Gu, Yifu Yang, Liang Chen et autres

Introduction: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Ursolic acid (UA) can be used in the MS treatment with anti-inflammatory and neuroprotective activities. However, UA is insoluble in water, which may affect its medication effectiveness. …

cn (code pays fourni par la source)

Epimedin B exhibits pigmentation by increasing tyrosinase family proteins expression, activity, and stability

Hong Chen, Yifan Zhang, Lili Yang, Haoyang Xu et autres

Epimedin B (EB) is one of the main flavonoid ingredients present in Epimedium brevicornum Maxim., a traditional herb widely used in China. Our previous study showed that EB was a stronger inducer of melanogenesis and an activator of tyrosinase (TYR). However, the …

cn (code pays fourni par la source)