Accès ouvert
2024
article
OpenAlex
Julie Daigre, Manuel Martinez-Osuna, Maria Bethke, Larissa Steiner et autres
Treatment options for ovarian cancer patients are limited, and a high unmet clinical need remains for targeted and long-lasting, efficient drugs. Genetically modified T cells expressing chimeric antigen receptors (CAR), are promising new drugs that can be directed towards a defined target …
de
(code pays fourni par la source)
2022
conference-abstract
OpenAlex
Christoph Herbel, Vera Dittmer, Manuel Martinez-Osuna, Sandy Reiß et autres
Abstract Major advances have been achieved in targeted immunotherapy with significant clinical benefits for patients. However, on-target/off-tumor toxicity is a major concern. This issue highlights the clinical need for better targets to improve the safety profile of immunotherapies. On-target/off-tumor toxicity is mainly …
de
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Accès ouvert
2022
article
OpenAlex
Ali Kinkhabwala, Christoph Herbel, Jennifer Pankratz, Dmytro A. Yushchenko et autres
Many critical advances in research utilize techniques that combine high-resolution with high-content characterization at the single cell level. We introduce the MICS (MACSima Imaging Cyclic Staining) technology, which enables the immunofluorescent imaging of hundreds of protein targets across a single specimen at …
de, us, gb
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Ali Kinkhabwala, Christoph Herbel, Jennifer Pankratz, Dmytro A. Yushchenko et autres
Abstract Many critical advances in research utilize techniques that combine high-resolution with high-content characterization at the single cell level. We introduce the MICS (MACSimaTM Imaging Cyclic Staining) technology, which enables the immunofluorescent imaging of hundreds of protein targets across a single specimen …
de, us
(code pays fourni par la source)
2020
article
OpenAlex
Christoph Herbel, Vera Dittmer, Manuel Martinez-Osuna, Laura Nadine Kuester et autres
Accès ouvert
2019
conference-abstract
OpenAlex
Christoph Herbel, Vera Dittmer, Manuel Martinez-Osuna, Laura Nadine Kuester et autres
Abstract Here we report the use of the MACSima™ imaging platform to perform high-content imaging for the pre-clinical validation of tumor target expression on tumor and healthy human tissues indicative for potential on-target/off-tumor toxicity in vivo. Major advances have been achieved in …
de
(code pays fourni par la source)
Accès ouvert
2019
conference-abstract
OpenAlex
Christoph Herbel, Vera Dittmer, Manuel Martinez-Osuna, Laura Nadine Kuester et autres
Here we report the use of the MACSima™ imaging platform to perform high-content imaging for the pre-clinical validation of tumor target expression on tumor and healthy human tissues indicative for potential on-target/off-tumor toxicity in vivo.Major advances have been achieved in cancer therapy …
de
(code pays fourni par la source)