Veronika Kalendová

Thermoneutral housing promotes hepatic steatosis in standard diet-fed C57BL/6N mice, with a less pronounced effect on NAFLD progression upon high-fat feeding

Olga Horakova, Gabriella Sistilli, Veronika Kalendová, Kristina Bardová et autres

Introduction Non-alcoholic fatty liver disease (NAFLD) can progress to more severe stages, such as steatohepatitis and fibrosis. Thermoneutral housing together with high-fat diet promoted NAFLD progression in C57BL/6J mice. Due to possible differences in steatohepatitis development between different C57BL/6 substrains, we examined …

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Metabolic effects of n-3 fatty acids administered as Calanus oil to transgenic mice lacking functional peroxisome proliferator-activated receptor alpha

Martin Rossmeisl, Veronika Kalendová, Olga Horakova

Effect of housing temperature on non-alcoholic fatty liver disease development in C57BL/6N mice

Olga Horakova, Gabriella Sistilli, Veronika Kalendová, Tomáš Čajka et autres

Krill Oil Supplementation Reduces Exacerbated Hepatic Steatosis Induced by Thermoneutral Housing in Mice with Diet-Induced Obesity

Gabriella Sistilli, Veronika Kalendová, Tomáš Čajka, Illaria Irodenko et autres

Preclinical evidence suggests that n-3 fatty acids EPA and DHA (Omega-3) supplemented as phospholipids (PLs) may be more effective than triacylglycerols (TAGs) in reducing hepatic steatosis. To further test the ability of Omega-3 PLs to alleviate liver steatosis, we used a model …

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Increased plasma levels of palmitoleic acid may contribute to beneficial effects of Krill oil on glucose homeostasis in dietary obese mice

Martin Rossmeisl, Jana Pavlišová, Kristina Bardová, Veronika Kalendová et autres

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Chronic n-3 fatty acid intake enhances insulin response to oral glucose and elevates GLP-1 in high-fat diet-fed obese mice

Jana Pavlišová, Olga Horakova, Veronika Kalendová, Jana Buresova et autres

n-3 polyunsaturated fatty acids (PUFA) can exert beneficial effects on glucose homeostasis, especially in obese rodents. Gut incretin hormones regulate glucose and lipid homeostasis, but their involvement in the above effects is not entirely clear. This study aims to assess the effects …

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Charakterizace metabolických účinků omega-3 mastných kyselin u transgenních myší s expresí humánního PPARα

Veronika Kalendová

Characterization of metabolic effects of dietary omega-3 fatty acids in transgenic PPARα-humanized mice

Veronika Kalendová

Obesity is tightly connected with metabolic diseases including insulin resistance, type 2 diabetes or dyslipidemia. Peroxisome proliferator-activated receptor (PPAR)-α is a key transcription factor involved in the regulation of lipid metabolism, while its activity is stimulated by a variety of hypolipidemic drugs. …

OR24: Dietary N-3 Fatty Acids as Phospholipids Improve Insulin Sensitivity of the Liver and Skeletal Muscle in Dietary Obese Mice

Martin Rossmeisl, Jana Pavlišová, Petra Kuchaříková, Veronika Kalendová et autres

Dysregulace endokanabinoidního systému při obezitě a jeho modulace pomocí omega-3 mastných kyselin v dietě

Veronika Kalendová

Dysregulation of the endocannabinoid system in obesity and its modulation by dietary omega-3 fatty acids

Veronika Kalendová

Obesity is associated with metabolic complications including insulin resistance, dyslipidemia and hypertension (metabolic syndrome). The endocannabinoid system (ECS) activity is elevated in obesity, which can further potentiate metabolic impairments. Pharmacological treatment based on the cannabinoid receptor CB1 blockade led to a decrease …