Shunchang Jiao

Chinese expert consensus on sequential surgery following conversion therapy based on combination of immune checkpoint inhibitors and antiangiogenic targeted drugs for advanced hepatocellular carcinoma (2024 edition)

Haowen Tang, Wenwen Zhang, Junning Cao, Yinbiao Cao et autres

Up to half of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage, for which effective treatment options are lacking, resulting in a poor prognosis. Over the past few years, the combination of immune checkpoint inhibitors and anti-angiogenic targeted therapy has …

cn, Éthiopie (code pays fourni par la source)

N-formylmethionine-leucyl-phenylalanine protects against irradiation-induced damage to hematopoiesis and intestines

Zhihua Li, Yatong Wu, Sinian Wang, Fengsheng Li et autres

BACKGROUND: Ionizing radiation (IR), including radiotherapy, can exert lasting harm on living organisms. While liposaccharide (LPS) offers resistance to radiation damage, it also induces toxic responses. Thankfully, an LPS analogue called N-formylmethionine-leucyl-phenylalanine (fMLP) holds the potential to mitigate this toxicity, offering hope …

cn (code pays fourni par la source)

LBA40 Primary results from the phase III ALTN-AK105-III-02 study: Anlotinib plus penpulimab versus sorafenib as first-line (1L) therapy for advanced hepatocellular carcinoma (aHCC)

Jin Zhou, Jie Fan, Shunchang Jiao, Li Bai et autres

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CXCL10 and IL15 co-expressing chimeric antigen receptor T cells enhance anti-tumor effects in gastric cancer by increasing cytotoxic effector cell accumulation and survival

Siyue Nie, Yujie Song, Kun Hu, Wei Zu et autres

Chimeric antigen receptor (CAR) T cells have demonstrated outstanding therapeutic success in hematological malignancies. Yet, their efficacy against solid tumors remains constrained due to inadequate infiltration of cytotoxic T and CAR-T cells in the tumor microenvironment (TME), a factor correlated with poor …

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Nomograms Predict PFS and OS for SCLC Patients After Standardized Treatment: A Real-World Study

Ke Li, Lupeng Qiu, Yang Zhao, Xiaohui Sun et autres

Purpose: This study aims to investigate the process of small cell lung cancer (SCLC) patients from achieving optimal efficacy to experiencing disease progression until death. It examines the predictive value of the treatment response on progression free survival (PFS) and overall survival …

cn (code pays fourni par la source)

First-line penpulimab combined with paclitaxel and carboplatin for metastatic squamous non-small-cell lung cancer in China (AK105-302): a multicentre, randomised, double-blind, placebo-controlled phase 3 clinical trial

Hua Zhong, Shengjie Sun, Jianhua Chen, Ziping Wang et autres

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Simultaneous changes of PD-1、PD-L1、CTLA-4、TGF-β1、HIF-1α、IL-2、IL-6 in peripheral blood of chemothepy-SCLC and their relation with clinical characteristics and survival

jihua yang, Shunchang Jiao, Juyi Wen, Wei Xing Zheng

This study was the first to report the prognostic value of PD-1, PD-L1, CTLA-4, TGF-β1, HIF-1α, IL-2 and IL-6 in peripheral blood on PFS and OS of SCLC.Few studies had reported the correlation between immune-related factors and SCLC survival in SCLC studies, …

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Sufficiently activated mature natural killer cells derived from peripheral blood mononuclear cells substantially enhance antitumor activity

C C Liu, Yingying Li, Yanrong Li, Meng Hu et autres

BACKGROUND: Peripheral blood-derived natural killer (NK) cells spontaneously lyse tumor cells without prior sensitization. However, NK cells in peripheral blood (PBNK cells) are in a resting state and exhibit inhibitory phenotypes and impaired cytotoxicity. Thus, strengthening the cytotoxic effector function of PBNK …

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Relationship Between MUC4 Variants and Metastatic Recurrence in Colorectal Cancer

Jieqiong Liu, Rongge Xing, Jiakang Shao, Shunchang Jiao

Background: Recurrent metastasis after radical resection in patients of colorectal cancer (CRC) is a great challenge for the world, in which genomic alterations play a major role in tumorigenesis. MUC4 plays a significant role in recurrence and metastasis in tumor. This study …

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Risk Stratification of Postoperative Adjuvant Therapy for Endometrial Cancer (POAT-ENDORISK) Based on Bayesian Network Model: A Development and Validation Study

Xue Hou, Si Sun, Shunchang Jiao, Jian Zhang et autres

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The level of macrophage migration inhibitory factor is negatively correlated with the efficacy of PD-1 blockade immunotherapy combined with chemotherapy as a neoadjuvant therapy for esophageal squamous cell carcinoma

Liangliang Wu, Yiming Gao, Shengzhi Xie, Ye Wan et autres

PURPOSE: This study aimed to screen biomarkers to predict the efficacy of programmed cell death 1 (PD-1) blockade immunotherapy combined with chemotherapy as neoadjuvant therapy for esophageal squamous cell carcinoma (ESCC). METHODS: In the first stage of the study, the baseline concentrations …

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Magnetic Resonance Diffusion Tensor Imaging Characterize the Hepatic Ischemia-Reperfusion Injury in an Animal Study

Minglu Liu, Cheng Zhang, Sandi Shen, Jiakang Shao et autres

Hepatic ischemia-reperfusion (I/R) injury is the main cause of morbidity and mortality after hepatectomy; thus, new methods for reducing I/R injury are required. The aim of this study is to evaluate changes in the average apparent diffusion coefficient (ADCavg) and fractional anisotropy …

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