Sonia Buffolino

CD56+/CD38+ Neutrophils: Rapid and Specific Flow Cytometric Signature for Chronic Myeloid Leukemia

Alessandro Laganà, Matteo Breccia, Loredana Elia, Emilia Scalzulli et autres

The CD56briCD38+ neutrophil subset in peripheral blood (PB) exceeding 2.0% may represent as a highly specific and rapid flow cytometric signature for the early detection of Chronic Myeloid Leukemia (CML).

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Rapid and accurate identification of acute promyelocytic leukemia with a novel multiparametric flow cytometric scoring system

David Fanciullo, Deborah Kasmi, Concetta Anna Germano, Maria Grazia Nardacci et autres

Not available.

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CD99 expression in acute myeloid leukemia with FLT3 internal tandem duplications (FLT3-ITD mut -AML): a flow-cytometric marker for an accurate diagnostic workup

Deborah Kasmi, Daniela Diverio, Maria Laura Bisegna, Ida Carmosino et autres

Internal tandem duplications of FLT3 (FLT3-ITD) in acute myeloid leukemia (AML) are associated with poor outcomes. CD99 is frequently overexpressed in AML and emerged as potential diagnostic marker. Ninety consecutive newly diagnosed AML patients were retrospectively analyzed. Immunophenotypic profiles were correlated with …

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A novel complex mutation in the exon 9 of CALR gene: p.E381fs*52 (gagg_CCTCTTTGCCTC)

Claudia Ielo, Sonia Buffolino, Attilio Di Lascio, Luisa Bizzoni et autres

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Late appearance of JAK2 mutated polycythaemia vera in a patient with typical chronic myeloid leukaemia on imatinib: Speculations about role of therapeutic pressure and of secondary genetic events

Gianfranco Lapietra, Maria Zaira Limongi, Sonia Buffolino, Mauro Nanni et autres

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A novel point mutation within the juxtamembrane domain of the flt3 gene in acute myeloid leukemia

Valentina Gianfelici, Daniela Diverio, Massimo Breccia, Sonia Buffolino et autres

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Interleukin (IL)‐3/granulocyte macrophage‐colony stimulating factor/IL‐5 receptor alpha and beta chains are preferentially expressed in acute myeloid leukaemias with mutated FMS‐related tyrosine kinase 3 receptor

Roberta Riccioni, Daniela Diverio, Viviana Riti, Sonia Buffolino et autres

The common beta chain subunit (beta(c)), also known as CDw131, shared by the interleukin-3 (IL-3), granulocytic macrophage colony-stimulating factor (GM-CSF) and IL-5 receptors, is required for high-affinity ligand binding and signal transduction. The present study explored the expression of CDw131 in 105 …

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Mlecular Monitoring of Acute Myeloid Leukemia Patients Carrying Nucleophosmin (NPM1) Mutations Undergoing An Autologous Peripheral Blood Stem Cell Transplantation

Valentina Gianfelici, Daniela Diverio, Saveria Capria, Silvia Maria Trisolini et autres

Abstract Nucleophosmin (NPM1) gene mutations represent the most common genetic alterations in adult acute myeloid leukemia (AML), accounting for about 30% of cases and 50–60% of AML with normal karyotype. In addition to their recognized prognostic value (when combined with analysis of …

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M4 and M5 acute myeloid leukaemias display a high sensitivity to Bortezomib‐mediated apoptosis

Roberta Riccioni, Mara Senese, Daniela Diverio, Viviana Riti et autres

The present study explored the sensitivity of leukaemic blasts derived from 30 acute myeloid leukaemia (AML) patients to Bortezomib. Bortezomib induced apoptosis of primary AML blasts: 18/30 AMLs were clearly sensitive to the proapoptotic effects of Bortezomib, while the remaining cases were …

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Expression of Tie-2 and Other Receptors for Endothelial Growth Factors in Acute Myeloid Leukemias Is Associated with Monocytic Features of Leukemic Blasts

Roberta Riccioni, Daniela Diverio, Gualtiero Mariani, Sonia Buffolino et autres

We investigated the expression of Tie-2 in primary blasts from 111 patients with acute myeloid leukemia (AML) to evaluate a possible linkage between the expression of this receptor and the immunophenotypic and biologic properties of leukemic blasts. Tie-2 was expressed at moderate …

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Prolonged molecular remission in a newly diagnosed acute promyelocytic leukaemia with a severe cardiomyopathy using low-dose gemtuzumab ozogamicin and all-trans retinoic acid

Vincenza Martini, Clara Minotti, Massimo Breccia, Gioia De Angelis et autres

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Repeated rituximab maintenance courses in fludarabine-failed young patients with chronic lymphocytic leukaemia responding to FAND chemotherapy

Laura Scaramucci, Pasquale Niscola, Sonia Buffolino, Velia Bongarzoni et autres