Zu‐Zhuang Wei

Synthesis and In Vitro Anticancer Activity of New Acridone Derivatives: Computational DFT and Molecular Docking Studies

Shu-Lin Zhang, Jiayan Chen, Jiajia Lan, Lin Mao et autres

ABSTRACT Cancer continuing to present a serious global health threat, creating an urgent demand for new and effective anticancer candidates. In this study, several novel acridone derivatives were synthesized and characterized by 1 H NMR, 13 C NMR, HRMS and FT‐IR, and …

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Discovery of a novel dual-targeting c-MYC and BCL-2 promoter G- quadruplexes ligand for the treatment of cervical cancer

Wenbo Yan, Hui Yuan, Nuan Li, Meimei Zhang et autres

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Correction: A novel platinum( ii ) complex with a berberine derivative as a potential antitumor agent targeting G-quadruplex DNA

Shulin Zhang, Haian Fu, Yingxia Ma, Qifu Lin et autres

Correction for ‘A novel platinum( ii ) complex with a berberine derivative as a potential antitumor agent targeting G-quadruplex DNA’ by Shu-Lin Zhang et al. , Org. Biomol. Chem. , 2025, https://doi.org/10.1039/d4ob01705f.

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A novel platinum( ii ) complex with a berberine derivative as a potential antitumor agent targeting G-quadruplex DNA

Shulin Zhang, Haian Fu, Yingxia Ma, Qifu Lin et autres

G-quadruplexes are considered attractive targets for various human diseases, including cancer therapy, owing to their potential therapeutic applications. Understanding the interaction between ligands and G-quadruplexes is crucial for the development of novel anticancer agents. In this study, we designed a novel platinum(II) …

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Syntheses and evaluation of acridone derivatives as anticancer agents targeting Kras promoter i-motif structure

Zu‐Zhuang Wei, Xiaomin Lin, Siyi Wang, Jiahui Zhang et autres

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Development of a Smart Fluorescent Probe Specifically Interacting with C-Myc I-Motif

Zu‐Zhuang Wei, Bobo Liu, Xiaomin Lin, Jing Wang et autres

I-motifs play key regulatory roles in biological processes, holding great potential as attractive therapeutic targets. In the present study, we developed a novel fluorescent probe G59 with strong and selective binding to the c-myc gene promoter i-motif. G59 had an i-motif-binding carbazole …

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Strong in vitro and in vivo cytotoxic effects of two platinum(II) complexes with cryptolepine derivatives

Li-Qin Qin, Zu‐Zhuang Wei, Lin Yang, Qi‐Pin Qin et autres

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Copper(II) and iron(III) complexes of chiral dehydroabietic acid derived from natural rosin: metal effect on structure and cytotoxicity

Bao‐Li Fei, Chun-Nuan Hui, Zu‐Zhuang Wei, Ling‐Yan Kong et autres

A novel optically pure dinuclear copper(II) complex of a rosin derivative dehydroabietic acid (DHA, HL) was synthesized and fully characterized. The in vitro antitumor activities of the copper(II) complex Cu2(µ2-O)(L)4(DMF)2 (1) were explored and compared with those of a trinuclear iron(III) complex …

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Transcriptional regulation of telomeric repeat-containing RNA by acridine derivatives

Shuangshuang Kang, Jiaojiao Cao, Meiling Zhang, Xiaoya Li et autres

Telomere is a specialized DNA–protein complex that plays an important role in maintaining chromosomal integrity. Shelterin is a protein complex formed by six different proteins, with telomeric repeat factors 1 (TRF1) and 2 (TRF2) binding to double-strand telomeric DNA. Telomeric DNA consists …

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Strong In Vitro And Vivo Cytotoxicity Of Two Platinum(II) Complexes With Cryptolepine Derivatives

Li-Qin Qin, Zu‐Zhuang Wei, Lin Yang, Qi‐Pin Qin et autres

Abstract Two mononuclear Pt(II) compounds, [Pt(BQL1)Cl]Cl (BQL1-Pt) and [Pt(BQL2)Cl]Cl (BQL2-Pt) with [5-(benzo[4,5]furo[3,2-b]quinolin-11-yloxy)-pentyl]-bis-pyridin-2-ylmethyl-amine (BQL1) and [9-(benzo[4,5]furo[3,2-b]quinolin-11-yloxy)-nonyl]-bis-pyridin-2-ylmethyl-amine (BQL2), were prepared as new chemotypes for potential antitumor agents. This study evaluated the influence of cryptolepine derivatives in BQL1-Pt, 2,2′-dipicolylamine Pt(II) complex, and BQL2-Pt on cellular …

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Syntheses and evaluation of acridone-naphthalimide derivatives for regulating oncogene PDGFR-β expression

Meiling Zhang, Zu‐Zhuang Wei, Xue Qian Gong, Xiaoya Li et autres

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High anticancer activity and apoptosis- and autophagy-inducing properties of novel lanthanide( iii ) complexes bearing 8-hydroxyquinoline- N -oxide and 1,10-phenanthroline

Yan Yang, Zhen Zhou, Zu‐Zhuang Wei, Qi‐Pin Qin et autres

In the quest for rare earth metal complexes with enhanced cancer chemotherapeutic properties, the discovery of seven lanthanide(iii) complexes bearing 8-hydroxyquinoline-N-oxide (NQ) and 1,10-phenanthroline (phen) ligands, i.e., [SmIII(NQ)(phen)(H2O)Cl2] (Ln1), [EuII(NQ)(phen)(H2O)Cl2] (Ln2), [GdIII(NQ)(phen)(H2O)Cl2] (Ln3), [DyIII(NQ)(phen)(H2O)Cl2] (Ln4), [HoIII(NQ)(phen)(H2O)Cl2] (Ln5), [ErIII(NQ)(phen)(H2O)Cl2] (Ln6), and [YbIII(NQ)(phen)(H2O)Cl2] (Ln7), …

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