Mingxu Xie

An exact formula for Erdős' problem 1005

Yanmohan Wang, Mingxu Xie, Ziyuan Zhao

In 1943, Erdős considered the minimum number $f(n)$ of terms between two fractions in the Farey sequence of order $n$ whose numerators and denominators are oppositely ordered. Determining the constant $c$ in $f(n)=(c+o(1))n$ is known as Erdős Problem 1005. Recently, Cipollini solved …

MCOLN2 (Mucolipin-2) promotes autophagy to confer Adriamycin resistance in breast cancer by regulating mTOR degradation

Hongyan Yu, Jie Wang, Yongchen Ji, Xiaofang Liu et autres

Abstract Background Adriamycin is a cornerstone chemotherapeutic agent for advanced breast cancer, but its efficacy is frequently compromised by chemoresistance, a process in which macroautophagy is critically involved. However, the underlying mechanisms driving this autophagy-mediated resistance remain poorly understood. Methods Clinical data …

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Gut microbiome in gastrointestinal cancer

Mingxu Xie, Jun YU

Research Progress on the Effect of Bacillus velezensis on Disease Resistance of Aquatic Animals

Xue Yan, Tingyu Zhu, Xu MengTing, Yue Wang et autres

With the rapid expansion of intensive aquaculture, the frequent outbreak of diseases and the overuse of antibiotics have become increasingly critical issues. Therefore, developing green and efficient antibiotic alternatives is essential for the sustainable growth of the industry. As a novel probiotic, …

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Dietary Zinc Supplementation Improves Growth, Antioxidant Capacity, Immunity, and Intestinal Health in Juvenile Black Carp (Mylopharyngodon piceus)

Jiaxing Yu, P Zhang, 张训尚, Xiaotong Zhu et autres

Zinc (Zn) is an essential trace element that plays important roles in growth, digestion, antioxidant defense, immunity, and inflammation regulation in fish. This study investigated the effects of graded dietary Zn levels on growth performance, serum biochemistry, digestive enzyme activity, zinc transporter …

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526 PARABACTEROIDES DISTASONIS SUPPRESSES METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE-RELATED HEPATOCELLULAR CARCINOMA AND POTENTIATES ANTI-PD-1 EFFICACY

Ruyi Zhang, Kai Yuan, Mingxu Xie, Ruijie Zeng et autres

526 PARABACTEROIDES DISTASONIS SUPPRESSES METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE-RELATED HEPATOCELLULAR CARCINOMA AND POTENTIATES ANTI-PD-1 EFFICACY

Ruyi Zhang, Kai Yuan, Mingxu Xie, Ruijie Zeng et autres

Bifidobacterium catenulatum boosts anti-PD-1 efficacy in microsatellite stable colorectal cancer via activating CD8 + T cells

Xiang Li, Mingxu Xie, Jason Xing Kang, Yue Chen et autres

Background Certain gut bacteria are associated with improved responses to immunotherapy. Objective We aim to identify bacteria that inhibit colorectal cancer (CRC) progression and enhance immunotherapy efficacy. Design The abundance of bacteria in CRC patients was evaluated in our in-house cohorts and …

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Adequate dietary zinc is effective in improving growth performance, metabolic ability, antioxidant capacity, and immunity in black carp (Mylopharyngodon piceus)

Jiaxing Yu, Penghui Zhang, 张训尚, Xiaotong Zhu et autres

Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity

Xiao Qiang Ding, Nick Lung-Ngai Ting, Chi Chun Wong, Pingmei Huang et autres

Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression

Mingxu Xie, Kai Yuan, Yongxin Zhang, Yating Zhang et autres

humanized mice and autologous patient-derived CRC organoids-CTLs co-culture system. To summarize, C. butyricum is a promising adjuvant to augment ICB therapy.

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The gut microbiota in cancer immunity and immunotherapy

Mingxu Xie, Xiang Li, Harry Cheuk-Hay Lau, Jun Yu

Abstract The human gastrointestinal tract harbors trillions of microorganisms, including bacteria, fungi, and viruses, to form the gut microbiota. Cumulative evidence has demonstrated the critical impact of gut microbes on cancer immunity. In cancer, an altered gut microbiota enriched with pathogenic bacteria …

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