E. P. Evdoshenko

Expanding the indications of cladribine tablets for multiple sclerosis: From early use in treatment-naive patients to the possibility of retreatment courses after 4 years of cladribine initiation therapy

Е. В. Попова, Н. В. Хачанова, M V Abroskina, M. V. Davydovskaia et autres

Autoimmune disorders are common clinical conditions that result from an abnormal immune response to the body’s own structures. Most existing immunomodulatory drugs for multiple sclerosis (MS) therapy are capable of suppressing autoimmune reactions as long as they are used, but they do …

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Divozilimab in neuromyelitis optica spectrum disorders: Evidence-based consensus of Russian committees of experts and clinical potential

В. С. Краснов, Ya. V. Vlasov, E. P. Evdoshenko, D. S. Korobko et autres

Neuromyelitis optica spectrum disorders (NMOSD) are a group of inflammatory diseases of the central nervous system. B-lymphocytes play leading role in their pathogenesis in most cases. СD20 surface antigen is one of the B-lymphocytes makers. There is extensive world experience with chimeric …

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Administration of siponimod in real clinical practice in Russia

M. V. Davydovskaia, N. Sh. Arzumanyan, E. A. Dubchenko, V. B. Sosina et autres

Introduction. The study was driven by the prevalence of secondary progressive multiple sclerosis (SPMS) in Russia and the lack of data on siponimod in the real clinical practice (RCP). Aim. To collect and analyze data on the administration of siponimod in SPMS …

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Anti-CD20 therapy and pregnancy planning in multiple sclerosis

Н. В. Хачанова, В. С. Краснов, E. P. Evdoshenko, Inessa Zakroyshchikova et autres

Pregnancy rates are rapidly increasing among women of reproductive age diagnosed with multiple sclerosis (MS). Over the past decades, several studies have proven that MS does not affect the course of pregnancy, and pregnancy does not negatively affect the long-term course of …

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Neuromyelitis optica spectrum disorders, terminology and therapeutic issues: amended consensus opinion

В. С. Краснов, I. V. Vlasov, E. P. Evdoshenko, D. S. Korobko et autres

In Russian Federation in 2022, the Expert Council adopted the main definitions and terms for neuromyelitis optica spectrum disorders (NMOSD) and proposed a treatment algorithm for patients with NMOSD with antibodies to aquaporin-4 (AQP4-IgG). The publication is intended to present the results …

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Early use of cladribine tablets for relapsing-remitting multiple sclerosis: Expert opinion

Е. В. Попова, M V Abroskina, K. Z. Bakhtiyarova, Ya. V. Vlasov et autres

In March 2020, oral cladribine was licensed in Russian Federation for the treatment of adult patients with highly active relapsing multiple sclerosis as defined by clinical or imaging features. Three years after the introduction into the Russian market, practical aspects in the …

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Validation of e-version of Russian-language expanded disability status scale (EDSS) for patients with multiple sclerosis in the Russian Federation

A.D. Stepanova, E. P. Evdoshenko, M. V. Shumilina, D. S. Korobko et autres

Objective. To assess the validity and reproducibility of e-version of the expanded disability status scale (eEDSS) compared to original paper form in English and paper form of the validated Russian-language EDSS. Material and methods. The study was conducted in 6 centers of …

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Validation of Russian-language version of the Expanded Disability Status Scale (EDSS) for patients with multiple sclerosis in the Russian Federation

A.D. Stepanova, E. P. Evdoshenko, M. V. Shumilina, D. S. Korobko et autres

Objective. To assess validity and reproducibility of Russian-language version of the Expanded Disability Status Scale (EDSS) compared to original paper English-language form of this scale. Material and methods. The study was conducted in 6 centers of the Russian Federation and approved by …

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Consensus opinion on the management of patients with neuromyelitis optica spectrum diseases: issues of terminology and therapy

В. С. Краснов, K. Z. Bakhtiyarova, E. P. Evdoshenko, D. S. Korobko et autres

Neuromyelitis optica spectrum disorders (NMOSD) are a group of inflammatory diseases of the central nervous system characterized by episodes of immune-mediated astrocytopathy, inflammatory demyelination and axonal damage, predominantly affecting the optic nerves and spinal cord. Currently, there are several unresolved issues that …

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Improvement of gait and balance in patients with multiple sclerosis after multidisciplinary physical rehabilitation: Analysis of real-world data in Russia

A.D. Stepanova, Gleb Makshakov, A. I. Kulyakhtin, I. V. Kalinin et autres

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Progressive resistance power training for gait and balance rehabilitation in multiple sclerosis: a pilot single-arm study

Kseniia V. Voinova, Gleb Makshakov, E. P. Evdoshenko

Background: Progressive resistance training (PRT) has been recognized as an effective rehabilitation tool for people with multiple sclerosis (pwMS), leading to increased muscle strength and improvements a gait, balance. However, still little is known about the effectiveness of muscle power training on …

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Results of Expert Council meeting on modern principles of treatment optimization in patients with relapsing-remitting multiple sclerosis using anti-CD20 monoclonal antibody

Н. В. Хачанова, D. S. Korobko, D. S. Kasatkin, Ya. V. Vlasov et autres

The article presents the results of the discussion of the use of anti-B-cell therapy in multiple sclerosis (MS). These cells play a significant role in immunoregulation in MS, not only by producing antibodies to myelin antigens after transformation into plasma cells, but …

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