Angelica Lin

Microenvironment-derived acetylated amino acids promote glioblastoma treatment resistance

Daniel Richard Wahl, Palavalasa Sravya, Leyla Altay, Kathy Do et autres

us (code pays fourni par la source)

Rac1 and CHK1 Converge on Abi-1 to Regulate DNA Repair Dependency and Treatment Response in Human Cancers

Yiheng Huang, Elizabeth C. McCulla, Jihan Park, Annabel Yang et autres

Radiation therapy (RT) resistance remains a major clinical challenge, yet biomarkers guiding precision radiosensitization are lacking. We previously demonstrated that Rac1 promotes RT resistance in glioblastoma (GBM) by inducing Abi-1-S323 dephosphorylation and enhancing non-homologous end joining (NHEJ). Here, we identify Abi-1-S323 as …

us, pr (code pays fourni par la source)

Adaptive nuclear GTP synthesis promotes glioblastoma treatment resistance and is a targetable vulnerability in patients

Andrew J. Scott, Ningning Liang, Wajd N. Al‐Holou, Jie Xu et autres

Abstract Glioblastoma (GBM), the most lethal of all brain cancers, resists therapy by rewiring metabolism and relying on GTP signaling to promote DNA repair and radiation therapy (RT) resistance. How GBM modulates GTP levels for this signaling in response to RT-induced DNA …

us, cn (code pays fourni par la source)

TMET-54. Rewiring of cortical glucose metabolism fuels human brain cancer growth

Andrew J. Scott, Anjali Mittal, Baharan Meghdadi, Alexandra O’Brien et autres

Abstract The brain avidly consumes glucose to fuel neurophysiology. Cancers of the brain, such as glioblastoma (GBM), relinquish physiological integrity and gain the ability to proliferate and invade healthy tissue. How brain cancers rewire glucose utilization to drive aggressive growth remains elusive. …

us (code pays fourni par la source)

TMIC-85. Microenvironment-derived acetylated amino acids promote glioblastoma DNA repair by rerouting glucose fates and enhancing histone acetylation

Sravya Palavalasa, Jack Freeman, Aditri Gokul, Ava Singer et autres

Abstract Genotoxic therapy resistance in glioblastoma (GBM) is mediated by rapid DNA repair. We hypothesized that non-malignant cells in the heterogenous GBM microenvironment assist rapid DNA repair in neoplastic cells. Supporting this hypothesis, intracranial GBM tumors (orthotopic GBM PDXs and syngeneic murine …

us (code pays fourni par la source)

Rewiring of cortical glucose metabolism fuels human brain cancer growth

Andrew J. Scott, Anjali Mittal, Baharan Meghdadi, Alexandra O’Brien et autres

The brain avidly consumes glucose to fuel neurophysiology1. Cancers of the brain, such as glioblastoma, relinquish physiological integrity and gain the ability to proliferate and invade healthy tissue2. How brain cancers rewire glucose use to drive aggressive growth remains unclear. Here we …

us (code pays fourni par la source)

Reciprocal links between methionine metabolism, DNA repair and therapy resistance in glioblastoma

Navyateja Korimerla, Baharan Meghdadi, Isra Haq, Kari Wilder-Romans et autres

ABSTRACT Glioblastoma (GBM) is uniformly lethal due to profound treatment resistance. Altered cellular metabolism is a key mediator of GBM treatment resistance. Uptake of the essential sulfur-containing amino acid methionine is drastically elevated in GBMs compared to normal cells, however, it is …

us, fr (code pays fourni par la source)

TMET-27. MACHINE LEARNING-BASED IDENTIFICATION OF METABOLIC FLUXES IN PATIENT BRAIN TUMORS

Baharan Meghdadi, Anjali Mittal, Andrew Scott, Ningning Liang et autres

Abstract Personalized oncology aims to match effective treatments for individual cancer patients based on the biology of an individual tumor. This approach is not possible for metabolic therapies due to our inability to quantify metabolic activity in patient tumors, even when patients …

us (code pays fourni par la source)

TMET-19. REWIRING OF CORTICAL GLUCOSE METABOLISM FUELS HUMAN BRAIN CANCER GROWTH

Andrew J. Scott, Anjali Mittal, Baharan Meghdadi, Sravya Palavalasa et autres

Abstract The brain avidly consumes glucose to fuel neurophysiology. Cancers of the brain, such as glioblastoma (GBM), lose aspects of normal biology and gain the ability to proliferate and invade healthy tissue. How brain cancers rewire glucose utilization to fuel these processes …

us (code pays fourni par la source)

TMET-28. RECIPROCAL LINKS BETWEEN METHIONINE METABOLISM, DNA REPAIR AND THERAPY RESISTANCE IN GLIOBLASTOMA

Navyateja Korimerla, Kari Wilder-Romans, Jie Xu, Isra Haq et autres

Abstract Glioblastoma (GBM) is uniformly lethal due to profound treatment resistance. Altered cellular metabolism is a key mediator of GBM treatment resistance. Uptake of the essential sulfur-containing amino acid methionine is drastically elevated in GBMs compared to normal cells, however, it is …

us, fr (code pays fourni par la source)

Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma

Erik R. Peterson, Peter Sajjakulnukit, Andrew J. Scott, Caleb Heaslip et autres

BACKGROUND: Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often carry a driver mutation on histone H3 converting lysine 27 to methionine (H3K27M). DMG-H3K27M are characterized by altered metabolism and resistance …

us, ca (code pays fourni par la source)

Abstract 1801: Rewiring of cortical glucose metabolism fuels human brain cancer growth

Andrew J. Scott, Anjali Mittal, Baharan Meghdadi, Sravya Palavalasa et autres

Abstract The brain avidly consumes glucose to fuel neurophysiology. Cancers of the brain, such as glioblastoma (GBM), lose aspects of normal biology and gain the ability to proliferate and invade healthy tissue. How brain cancers rewire glucose utilization to fuel these processes …

us (code pays fourni par la source)