Yiheng Huang

Rac1 and CHK1 Converge on Abi-1 to Regulate DNA Repair Dependency and Treatment Response in Human Cancers

Yiheng Huang, Elizabeth C. McCulla, Jihan Park, Annabel Yang et autres

Radiation therapy (RT) resistance remains a major clinical challenge, yet biomarkers guiding precision radiosensitization are lacking. We previously demonstrated that Rac1 promotes RT resistance in glioblastoma (GBM) by inducing Abi-1-S323 dephosphorylation and enhancing non-homologous end joining (NHEJ). Here, we identify Abi-1-S323 as …

us, pr (code pays fourni par la source)

IL-21 enhances the cytotoxicity of intratumoral CD8+ T cells, improving radiation efficacy

Xinyang Li, Xueqi Xie, Baochao Wei, Xiaozheng Sun et autres

Radiotherapy is a critical modality in cancer treatment, not only to eradicate cancer cells but also to trigger antitumor immunity. IL-21, an immunomodulatory cytokine with potential in cancer therapy, has unexplored synergy with radiotherapy. Our study, leveraging human cancer databases and tissue …

cn (code pays fourni par la source)

Dysregulated immune system in chronic stress male rats is an outcome of altered mRNA expression, cytokines, and Th1/Th2 balance

Yiheng Huang, Qikang Gao, Gonglin Hou, Jianzhong Shao et autres

cn (code pays fourni par la source)

Global, regional and national burden of pancreatitis in children and adolescents, 1990–2021: a systematic analysis for the global burden of disease study 2021

Derong Lin, Yue Li, Xiaohua Xie, Bin Zhang et autres

BACKGROUND: Pancreatitis poses a significant global health burden, disproportionately affecting children and adolescents. This study uses the global burden of disease (GBD) 2021 dataset to evaluate pancreatitis epidemiology in this demographic, focusing on disparities by age, sex, and region. OBJECTIVE: To assess …

cn (code pays fourni par la source)

Hydration kinetics, pore refinement and performance enhancement of cementitious materials modified with NO2-LDHs and NO2-LDHs@MMT

xiaoyi zhang, Yiheng Huang, Shenglan Ma, Guo Liang Lin et autres

cn (code pays fourni par la source)

Unraveling the mechanisms of RECQL4-mediated cervical cancer progression through the PI3K/AKT pathway

Wen Huo, Yiheng Huang, Baoqinq Tian, Xiaozheng Chen et autres

BACKGROUND: RECQL4 is a member of the DNA helicase family and is critical for DNA replication, DNA damage repair, and tumor progression. However, its specific role in cervical cancer remains uncertain. METHODS: In this study, we aimed to investigate the impact of …

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Targeting white adipose tissue to combat insulin resistance

Yiheng Huang, Pingyi Gao, Lawrence H. Young, Dake Qi

ca, us (code pays fourni par la source)

Downregulation of adipose LPL by PAR2 contributes to the development of hypertriglyceridemia

Yiheng Huang, Liujun Chen, Li‐Sha Li, Yadan Qi et autres

Lipoprotein lipase (LPL) hydrolyzes circulating triglycerides (TGs), releasing fatty acids (FA) and promoting lipid storage in white adipose tissue (WAT). However, the mechanisms regulating adipose LPL and its relationship with the development of hypertriglyceridemia are largely unknown. WAT from obese humans exhibited …

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Reviving Intervertebral Discs: Treating Degeneration Using Advanced Delivery Systems

Hong Zhang, Xiaorong Yang, Yiheng Huang, Yue Li et autres

Intervertebral disc degeneration (IVDD) is commonly associated with many spinal problems, such as low back pain, and significantly impacts a patient's quality of life. However, current treatments for IVDD, which include conservative and surgical methods, are limited in their ability to fully …

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A pref-1-controlled non-inflammatory mechanism of insulin resistance

Yiheng Huang, Donghong Cui, Liujun Chen, Haibin Tong et autres

While insulin resistance (IR) is associated with inflammation in white adipose tissue, we report a non-inflammatory adipose mechanism of high fat-induced IR mediated by loss of Pref-1. Pref-1, released from adipose Pref-1+ cells with characteristics of M2 macrophages, endothelial cells or progenitors, …

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Glutathione, polyamine, and lysophosphatidylcholine synthesis pathways are associated with circulating pro-inflammatory cytokines

Ming Liu, Hongwei Zhang, Zikun Xie, Yiheng Huang et autres

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Restricting Branched-Chain Amino Acids within a High-Fat Diet Prevents Obesity

Ming Liu, Yiheng Huang, Hongwei Zhang, Dawn Aitken et autres

Obesity is a global pandemic, but there is yet no effective measure to control it. Recent metabolomics studies have identified a signature of altered amino acid profiles to be associated with obesity, but it is unclear whether these findings have actionable clinical …

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