Benjamin P. Frischhertz

Natural language processing to build a computable phenotype library for adults with congenital heart disease

Fernando Baraona Reyes, Rohith Vanam, Timothy A. Miller, Eric Farber-Eger et autres

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Natural language processing to build a computable phenotype library for adults with congenital heart disease

Spencer Thomas, Angus Dawson, Hifsa Chaudhry, Sidra Ahmad et autres

OBJECTIVE: Our objective was to build classifiers for multiple phenotypes that categorize a cohort of adults with congenital heart disease (ACHD), that can be used to populate variables in a biobank. MATERIALS AND METHODS: A dataset of 1492 ACHD patients, with expert-created …

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The FUEL FALD Study: Effects of Udenafil on Liver Stiffness and Fibrosis after Fontan

Kurt R. Schumacher, Jonathan Dillman, David J. Goldberg, Mark J. Cartoski et autres

Fontan-associated liver disease (FALD) is a fibrotic liver disease in individuals with Fontan physiology. This study sought to determine the efficacy of treatment with udenafil, a phosphodiesterase type 5 inhibitor, for reducing liver congestion leading to a decreased liver stiffness and reduction …

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26-CCC-17044-ACC FONTAN FAILURE WITH NORMAL HEMODYNAMICS: TAKING THE ROAD LESS TRAVELED

Kyle Saysana, Christopher Baron, Thomas P. Doyle, Michael G. Earing et autres

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Natural Language Processing to Build a Multicenter Computable Phenotype Library for Adults with Congenital Heart Disease

Spencer A. Thomas, Sidra Ahmad, Xiyu Ding, Sarah A. Hummel et autres

Objective: Our objective was to build classifiers for multiple phenotypes that categorize a cohort of adults with congenital heart disease (ACHD), that can be used to populate variables in a biobank. Materials and methods: A dataset of 1492 ACHD patients, with expert-created …

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Revisiting the Effect of Udenafil on Exercise Performance in Patients With Fontan Circulation: Results of a Post Hoc Analysis of the FUEL Trial

DAVID J. GOLDBERG, Victor Zak, Chenwei Hu, Adam M. Lubert et autres

Background In the FUEL (Fontan Udenafil Exercise Longitudinal) trial, a positive treatment effect was identified for outcomes at the ventilatory anaerobic threshold but not for the primary outcome, oxygen consumption (V o 2 ) at peak exercise. This disparate response may be …

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Single organ transplant for transposition of the great arteries

Tripti Gupta, Kayla Buttafuoco, Kara K. Siegrist, Kelly Louise Mishra et autres

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Diastolic dysfunction in patients with Fontan palliation is associated with death and heart transplantation

Edward H. Hardison, Christopher C. Henderson, Rachel K. Duncan, Kristen George‐Durrett et autres

BACKGROUND: Adults with Fontan failure (FF) have variable presentations and are often diagnosed late. Reliable predictors of FF are unknown. Diastolic dysfunction may be associated with adverse outcomes late after Fontan palliation. METHODS: <50% predicted, or new diuretic requirement. All phases in …

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Abstract 4123478: The Impact of Social Determinants on Growth at 10 Years After the Norwood Procedure: Results from the Single Ventricle Reconstruction (SVR) Trial III

Cathleen R. Pruitt, Linda M. Lambert, Zhining Ou, Caren S. Goldberg et autres

Background: The impact of social determinants of health (SDOH) on growth in patients with hypoplastic left heart syndrome (HLHS) is understudied. In a secondary analysis of the Pediatric Heart Network SVR III study, we explored the impact of SDOH on longitudinal somatic …

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Hybrid Stenting of Pulmonary Venous Baffle Stenosis

Daniel Kyrillos Ragheb, Steven J. Healan, Benjamin P. Frischhertz, George T. Nicholson et autres

A 31-year-old woman with transposition of the great arteries status post-Senning operation presents with severe pulmonary venous baffle obstruction. Both standards of care (percutaneous stenting or open repair) were deemed suboptimal and/or high risk. A multidisciplinary, hybrid approach via subxiphoid incision, guided …

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Rejection in the setting of combined Heart and Liver Transplantation

Shuktika Nandkeolyar, Tripti Gupta, D. Marshall Brinkley, Sophoclis P. Alexopoulos et autres

Introduction: Each year the number of combined heart-liver transplants (HLT) increases, with two distinct patient populations proceeding down this pathway. The first are patients with congenital heart disease (CHD), most commonly single ventricle patients palliated with Fontan. The second group are those …

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COVID-19–Related Thrombotic and Bleeding Events in Adults With Congenital Heart Disease

Flavia Fusco, Richard A. Krasuski, Soraya Sadeghi, Marlon Rosenbaum et autres

Altered coagulation is a striking feature of COVID-19. Adult patients with congenital heart disease (ACHD) are prone to thromboembolic (TE) and bleeding complications. The purpose of this study was to investigate the prevalence and risk factors for COVID-19 TE/bleeding complications in ACHD …

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