Leila Neshatian

Cover Image

Chris Varghese, Nicky Dachs, Gabriel Schamberg, Thomas Abell et autres

The cover image is based on the article Expert Clinical Consensus on Body Surface Gastric Mapping Phenotypes for Gastroduodenal Disorders: ‘Auckland Classification’ v1.0 by Chris Varghese et al., https://doi.org/10.1111/nmo.70377.

Expert Clinical Consensus on Body Surface Gastric Mapping Phenotypes for Gastroduodenal Disorders: ‘Auckland Classification’ v1.0

Chris Varghese, Nicky Dachs, Gabriel Schamberg, Thomas Abell et autres

INTRODUCTION: Chronic gastroduodenal disorders remain challenging to manage, and new diagnostic approaches are needed to better delineate underlying causes and guide therapeutic decisions. Body Surface Gastric Mapping (BSGM) technologies combine high-resolution gastric myoelectrical activity measurements with symptom and psychological profiling to provide …

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Methane Trajectory Phenotypes on Glucose Breath Testing Are Associated With Slow Colonic Transit: A Group‐Based Trajectory Modeling Analysis

Jarongkorn Sirimongkolkasem, Briana Valencia, Laren Becker, Sean P. Spencer et autres

ABSTRACT Background Intestinal methanogen overgrowth (IMO) is defined by a single binary threshold of CH 4 ≥ 10 ppm and is associated with slow transit constipation. We aimed to identify distinct breath methane trajectory phenotypes in patients with constipation and test their …

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Recurrence After Rectopexy: Insights From Magnetic Resonance Defecography

Rachel E. Colbran, Leila Neshatian, Vipul Sheth, Leora A. Cohen-Tigor et autres

BACKGROUND: Rectal prolapse recurrence after surgical repair remains a major limitation. Prior research surrounding recurrence risk has yielded inconsistent results and assessed a limited range of factors. OBJECTIVE: To evaluate whether preoperative magnetic resonance defecography, anorectal manometry, or balloon expulsion testing could …

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Functional and Anatomical Significance of Patulous Anus

Leila Neshatian, Mohamad I. Itani, Ofer Fass, George Triadafilopoulos et autres

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Anorectal Disorders

Satish S.C. Rao, Adil E. Bharucha, Emma V. Carrington, Ugo GROSSI et autres

This article defines the diagnostic criteria and reviews clinical evaluation and management of fecal incontinence, anorectal pain, dyssynergic defecation, and rectal hyposensitivity and hypersensitivity. Diagnostic evaluation includes anorectal manometry, balloon expulsion test, anal ultrasound, magnetic resonance imaging, defecography, and neurophysiology testing. Fecal …

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Autonomic Dysfunction in Gastroduodenal Disorders Evaluated Through Multimodal Non-Invasive Physiological Testing

Chris Varghese, Wendy Zhou, Armen A. Gharibans, Gabriel Schamberg et autres

INTRODUCTION: Chronic gastroduodenal disorders are highly prevalent and encompass heterogeneous pathophysiology. Autonomic dysfunction may contribute, but its relative contribution to disease pathophysiology and symptoms is unclear. This study aimed to clarify the contributions of autonomic dysfunction in gastroduodenal disorders and symptom associations …

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Distinct Phenotypes of Full‐Thickness Rectal Prolapse in Women: A Comparison of Defecation‐Only and Spontaneous Presentations

Zeyi Zhou, Michelle Earley, Sydni Au Hoy, Vipul Sheth et autres

BACKGROUND: While some patients report full thickness rectal prolapse (RP) exclusively during defecation, others may experience it spontaneously during walking, exercise, and/or all the time. We hypothesized that patients with RP only during defecation have more preserved physiological and anatomical characteristics and …

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Perception of rectal prolapse symptoms in patients with psychiatric disorders

Nouf Akeel, Charlotte M. Rajasingh, Michelle Earley, Sydni Au Hoy et autres

BACKGROUND The perception of symptoms in individuals with rectal prolapse (RP) can be influenced by psychiatric disorders (PD). It was hypothesized that women with a history of PD would experience higher levels of bother from RP symptoms. AIM To examine the relationship …

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AGA Clinical Practice Update on Evaluation and Management of Refractory Constipation: Expert Review

Kyle Staller, Leila Neshatian, Anthony J Lembo, Adil E. Bharucha

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Psychological Symptoms and Adverse Childhood Experiences Negatively Impact Coexisting Obstructed Defecation and Fecal Incontinence Symptoms

Elisa Karhu, Brooke Gurland, Meredith Craven, Dany Lamothe et autres

INTRODUCTION: Many patients with obstructed defecation report concurrent fecal incontinence. However, the impact of psychological factors on coexisting symptoms remains unclear. We aimed to investigate the association between history of adverse childhood experiences (ACEs) and psychological symptoms on the severity of coexisting …

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Evacuation Dysfunction Does Not Impact Breath Test Results

Céline P. Soetaert, Mohamad I. Itani, George Triadafilopoulos, Sean P. Spencer et autres

BACKGROUND: Evacuation dysfunction affects gastrointestinal motility, yet its effect on small bowel microbiota is unknown. We aimed to compare the glucose breath test (GBT) and lactulose breath test (LBT) outcomes in patients with or without evacuation dysfunction based on high-resolution anorectal manometry …

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