Accès ouvert
2026
article
OpenAlex
Nicholas Sunderland, Géraldine Asselin, Albert Henry, Christopher P. Nelson et autres
Background: Excess adiposity, most commonly indexed through body mass index (BMI), is strongly associated with the development of heart failure (HF). Weight loss therapies improve outcomes in patients with obesity and HF with preserved left ventricular ejection fraction (LVEF), but their effects …
Accès ouvert
2026
article
OpenAlex
Michael E. Wechsler, Sally E. Wenzel, Steve D. Groshong, Mario Castro et autres
ABSTRACT Background Biologics targeting type 2 cytokines can inhibit airway inflammation and improve lung function in moderate‐to‐severe asthma; however, their impact on airway mucosal inflammatory cells is unclear. This study assessed the effects of dupilumab on airway mucosal and systemic inflammation, and …
us, gb, de, fr
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Nicholas P. Sunderland, Géraldine Asselin, Albert Carl Henry, Christopher P. Nelson et autres
BACKGROUND: Excess adiposity, most commonly indexed through body mass index (BMI), is strongly associated with the development of heart failure (HF). Weight loss therapies improve outcomes in patients with obesity and HF with preserved left ventricular ejection fraction (LVEF), but their effects …
gb, ca, nl, us, se, my, nz, fr
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Joyce Nyaucha Njoroge, Sandra Sanders van Wijk, Thomas R. Austin, Jennifer A. Brody et autres
BACKGROUND: Heart failure (HF) and its main subtypes, heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF), impose an enormous health burden on elders. Assessment of the circulating proteome to illuminate pathogenesis could open new opportunities …
us, nl, tw, gb, ch, is
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Katie Watts, Matthias Hübenthal, Heming Xing, Silke Szymczak et autres
Abstract Introduction and aims Atopic dermatitis (AD) is a common inflammatory skin disease with varying severity. In this large-scale multiomics study, we used a set of complementary methods and datasets to identify molecular markers with the most robust evidence for involvement in …
gb, de, us, fi, at, se
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Katie Watts, Matthias Hübenthal, Silke Szymczak, Hannah Cherry et autres
Abstract Atopic dermatitis (AD) is a common skin disease with most of the health, social and economic impact driven by those with more severe disease. Determining the molecular pathways that influence severity is therefore crucial, offering opportunity to identify novel drug targets, …
gb, de, us, fi, lu, at, ee, no, se, nl, fr, dk, ch
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Mithilesh Kumar Jha, Yingnan Han, Zhipeng Liu, Yannis Hara et autres
BACKGROUND: Anti-type 2 cytokine therapies represent promising interventions for chronic itch; however, their precise mechanisms in restoring nerve architecture and mitigating inflammation and pruritus remain incompletely understood. OBJECTIVES: This study aimed to elucidate the mechanistic roles of IL-4, IL-13, and IL-31 in …
us, fr
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
L. Zhang, Ellen C Lee, E. Wang, Zhe Zhang et autres
Abstract RATIONALE: The molecular and cellular mechanisms underpinning therapeutic responses across all types of asthma are not understood. One challenge is the difficulty of performing airway sampling by sputum induction or bronchoscopy to adequately power integrative analyses. Transcriptional phenotyping of nasal brushings …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Eun Lee, Liyuan Zhang, Zhe Zhang, Hui‐Chen Cheng et autres
Abstract RATIONALE: Asthma is a heterogeneous airway disease treated using various approaches based on disease severity. To uncover regulatory mechanisms and advance precision treatment of asthma, we developed a framework that leverages the rich gene correlation structures of the comprehensive, multimodal, longitudinal …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Young Min Han, Shalaka R. Patki, Heming Xing, Corneliu Alexandru Bodea et autres
Abstract Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous inflammatory disease with several endo-phenotypes and clinical presentations. COPD patients present with the ‘canonical’ neutrophilic inflammation as well as eosinophilic inflammation. The lungs from COPD patients show elevated levels of IL-13 and …
us, fr, gb, be
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Eileen Wang, Eunyoung Lee, Liyuan Zhang, Zhe Zhang et autres
Abstract RATIONALE: Despite greater understanding of asthma heterogeneity and pathogenesis, real-world longitudinal disease trajectories in the era of biologics and predictors of treatment response remain unclear. The RE al-world and G enomic data-based A sthma I nsights through N etwork analysis (REGAIN) …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Linda Joanne Rogers, Eunyoung Lee, Li Zhang, Zhe Zhang et autres
Abstract RATIONALE: Clinical remission is increasingly the goal of asthma treatment, however therapeutic response and mechanisms underpinning remission are poorly understood. To advance mechanistic understanding of treatment response in asthma, we conducted the RE al-world and G enomic data-based A sthma I …
us
(code pays fourni par la source)