Brian Gaffney

Safety and Efficacy of Renal Denervation in Patients Taking Antihypertensive Medications

David E. Kandzari, Raymond R. Townsend, Kazuomi Kario, Felix Mahfoud et autres

BACKGROUND: Renal denervation (RDN) reduces blood pressure (BP) in patients with uncontrolled hypertension in the absence of antihypertensive medications. OBJECTIVES: This trial assessed the safety and efficacy of RDN in the presence of antihypertensive medications. METHODS: SPYRAL HTN-ON MED is a prospective, …

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The Diastolic Blood Pressure J-Curve in Hypertension Management: Links and Risk for Cardiovascular Disease

Brian Gaffney, Alan P. Jacobsen, Abhishek Wilson Pallippattu, Niall Leahy et autres

PURPOSE OF REVIEW: The treatment of hypertension has changed dramatically over the last century, with recent trials informing clinical guidelines that recommend aiming for lower blood pressure (BP) targets than ever before. However, a "J"- or "U-shaped curve" in the association between …

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The “Superiority” of Enoxaparin for Treatment of Acute Coronary Syndromes

John Noviasky, Brian Gaffney

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Sick sinus syndrome: mechanisms and management.

Brian Gaffney, Alan G. Wasserman, A Rotsztain, Jhonny Ríos

Sick sinus syndrome has become a frequent and challenging diagnosis for the practicing physician (Fig. 6). Increased longevity will create even more patients in need of effective therapy. Multiple etiologies have been described, but the common final pathway in most instances appears …