Stephen Cornwell

Fundamentals on the Kinetic and Thermodynamic Analysis of Oligonucleotide DNA Hybridization by Surface Plasmon Resonance: A Guide for HIF1α Antisense Design

Stephen Cornwell, Frank Podlaski, Kenny Wong, Brian McKittrick et autres

Abstract Antisense oligonucleotides (ASO) are nucleotide polymers that hybridize to sense strands and have been successful in treating a variety of diseases. A wide range of strategies have been investigated to optimize and develop ASO for clinical studies. A key objective for …

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Peptide Nucleic Acids Containing Cationic/Amino-Alkyl Modified Bases Promote Enhanced Hybridization Kinetics and Thermodynamics with Single-Strand DNA

Frank Podlaski, Stephen Cornwell, Kenny K. Wong, Brian A. McKittrick et autres

Peptide nucleic acids (PNAs) are antisense molecules with excellent polynucleotide hybridization properties; they are resistant to nuclease degradation but often have poor cell permeability leading to moderate cellular activity and limited clinical results. The addition of cationic substitutions (positive charges) to PNA …

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Design and biological characterization of a series of dual mechanism ERK1 /2 inhibitors with a Triazolopyridinone core

Sajedeh Lotfaliansaremi, Stephen Cornwell, Candice Casillas, Michael L. Sabio et autres

Oncology clinical development programs have targeted the RAS/RAF/MEK/ERK signaling pathway with small molecule inhibitors for a variety of cancers during the past decades, and most therapies have shown limited or minimal success. Specific BRAF and MEK inhibitors have shown clinical efficacy in …

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Sugar and Spice

Debbie, Stephen Cornwell

Sugar and spice make everything nice, and tonight your true love you’ll surely entice!

Undress Rehearsals

Debbie, Stephen Cornwell

Step One:

Over the Threshold

Debbie, Stephen Cornwell

Step One:

Introduction

Debbie, Stephen Cornwell

JUST MARRIED…

To Have and To Hold

Debbie, Stephen Cornwell

Your salad can be as provocative as your entrée, whether served as the introduction or the conclusion of your meal. It should delight the eye of your Epicurean mate, suggesting the uniqueness of the hours that lie ahead. This can be a …

Unbridaled Passions

Debbie, Stephen Cornwell

Fillet of Sole in Tarragon Butter Step One: 2 Tbsp. butter 3/4 cup sliced mushrooms 1 small onion, chopped Melt butter in large fry pan and sauté mushrooms and onion for 5 minutes. Step Two: 1 lb. fillet of sole, patted dry …

Bouquets and Garters

Debbie, Stephen Cornwell

In the wedding ceremony the bridal veil suggests mystique, the bouquet adds an air of innocence, and the garter provides a glimpse of things to come! Just as every element of the bride’s attire contributes to the romance of the day, so …

The Facts of Life

Debbie, Stephen Cornwell

Now that you’re married, you owe it to yourselves to understand all the facts of life! Sure, Mom and Dad told you a lot, but there were a few things even your best friends couldn’t share. They knew you had to be …

To Have and To Hold

Debbie, Stephen Cornwell